rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Antifungal properties of Piper sarmentosum leaf extracts against Trichophyton rubrum and Malassezia furfur
  name:
    name part: Nurul 'Adani Sanusi
    role:
      role term: creator
    role:
      role term: author
  name:
    name part: Universiti Sultan Zainal Abidin
  type of resource: text
  genre: Dissertations, Academic
  origin info:
    place:
      place term: my
    date issued: 2017
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: print
    extent: xvii, 118 leaves: illustrations (some colour); 31 cm.
  abstract: T. rubrum and Malassezia furfur are common fungal pathogens causing skin infections. In immunocompromised patients, these fungi have been reported to cause widespread and invasive infections. Treatment with currently available antifungal agents may lead to unfavourable side effects and the emergence of resistant strains. Piper sarmentosum or locally known as kaduk has been reported to have antibacterial and antifungal properties. However, to date, its antifungal properties against these fungi have not been extensively reported. The objective of this study is to evaluate the antifungal properties of P. sarmentosum leaf extracts against these fungi. Three different solvents were used to extract the P. sarmentosum leaves. The solvents were n-Hexanc (non-polar), dichlorornethane (semi-polar), and ethanol (polar). Antifungal properties of the extracts were determined by the disc diffusion and broth dilution methods. The inhibition zone was measured and the Minimum Inhibitory Concentration (MIC) and Minimum Fungicidal Concentration (MFC) were determined. Total phenolic acids and flavonoids contents were estimated by Folin-Ciocalteu and colorimetric assay respectively. The morphological changes of the treated fungi ware observed under a Scanning Electron Microscope (SEM). The correlation between antifungal properties of the compound content of the extracts also determined. All types of extracts have exhibited antifungal properties against T. rubrum and M. furfur furfur. Among the extracts, dichloromethane leaf extract has demonstrated the highest antifungal properties whereby at the concentration of S mg/mL, it has started to show signs of inhibition indicated by the presence of inhibition zone with the diameter of 6.67± I. IS rnm for T. rubrum and 6.67±0.S8 rnrn for M. furfur. These results were in line with the MIC and MFC results where the dichlorornethane leaf extract exhibited the lowest MIC (S mg/mL) and MFC (10 mg/rnl.) for both fungi. Dichlorornethane leaf extract …
  table of contents: 1. introduction -- 2. literature review -- 3.methodology -- 4. result and discussion -- 5. conclusion and recommendation
  note: Nurul 'Adani binti Sanusi.
  note: Thesis (Degree of Master of Sciences) - Universiti Sultan Zainal Abidin, 2018
  note: Includes bibliographical references (leaves 84-102)
  subject:
    name:
      name part: Universiti Sultan Zainal Abidin --
    topic: Faculty of Medicine
  subject:
    name:
      name part: Universiti Sultan Zainal Abidin --
    topic: Dissertations
  subject:
    topic: Malassezia
  subject:
    topic: Trichophyton
  subject:
    topic: Tinea
  subject:
    topic: Antifungal antibiotics
  subject:
    topic: Antifungal Agents
  classification: RS431.A62
  classification: QV 252 N974a 2018
  record info:
    record content source: UniSZA
    record creation date: 181107
    record change date: 20201223090000.0
    record identifier: 0000094910