rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Effects of thymoquinone on neurotoxic rats induced by 3,4 methylenedioxymethamphetamine (MDMA)
  name:
    name part: Nor Suliana Mustafa
    role:
      role term: creator
  name:
    name part: Universiti Sultan Zainal Abidin
  type of resource: text
  origin info:
    place:
      place term: my
    date issued: 2020
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: print
    extent: xviii, 133leaves: illustration (some colour); 30cm.
  abstract: Ecstasy (3,4-methylenedioxymethamphetamine; MDMA) is a psychoactive substance that is associated with neurotoxicity. The MDMA exposure on human results in alteration of serotonin (5-HT) released by brain and leads to degeneration of neuronal cells in hippocampus. Most of the treatments available to treat the effects of MDMA are synthetic drugs that can cause severe side effects. An alternative medicine that has less side effects is suggested to treat neurotoxicity caused by MDMA. Thymoquinone (TQ), which is an active compound from Nigella sativa was studied for its protective effect towards nerotoxicity in various models. In spite of that, there is lack od scientific evidences on the effects of TQ in the model of MDMA-induced neorotoxicity. Hence, this study aimed to investigate the effects of TQ on MDMA-induced nerotoxicity based on 5-HT level, sign of anxiety, recognition memory and neuronal damage in rats. The induction of MDMA neurotoxicity was done with two different dosages to stimulate 5-HT depletion and neuronal damage on rats. The administration of TQ into MDMA-induced 5-HT depletion rats was carried out in male Sparaque Dawley via 1-week treatment dividing into four groups (n=32, 6-8 per group). The studies groups involved with the treatments comprise i) Control (1 mL/kg saline), ii) MDMA (single administration of 20 mg/kg MDMA), iii) MDMA-TQ (single administration of 20 mg/kg MDMA + 40 mg/kg TQ) and iv) TQ (40mg/kg TQ). Anxiety test was subjected to a light-dark test and social interaction test. Cerebrospinal fluid was collected from the cisterna magna to determine the level of 5-HT by means of Enzyme-Link Immunosorbent Assay (ELISA). Meanwhile, the administration of TQ into MDMA-induced neuronal damage rats wa carried out in male Sparaque Dawley via 1-week treatment dividing into four groups ((n=32, 7-9 per group). The studied groups involved with the treatments comprise i) Control (1 mL/kg saline), ii) MDMA (10 mg/kg MDMA), iii) MDMA-TQ (10 mg/kg MDMA +…
  table of contents: 1. Introduction -- 2. Literature Review -- 3. Materials and Methods -- 4. Result -- 5. Discussion -- 6. Conclusion
  note: Nor Suliana Mustafa.
  note: Thesis (Degree of Master of Science) - Universiti Sultan Zainal Abidin, 2020
  note: Includes bibliographical references (leaves 100 - 119)
  subject:
    name:
      name part: Universiti Sultan Zainal Abidin --
    topic: Faculty of Medicine
  subject:
    name:
      name part: Universiti Sultan Zainal Abidin --
    topic: Dissertations
  subject:
    topic: Ecstasy --
    geographic: Malaysia
  subject:
    topic: Amphetamines
  subject:
    topic: N-Methyl-3,4-methylemedioxyamphetamine
  classification: QV 102 N822e 2020
  record info:
    record content source: UniSZA
    record creation date: 200706
    record change date: 20210418090000.0
    record identifier: 0000098876