rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Biological dynamics of hepatitis C virus infection in haemodialysis patients in Pahang Darul Makmur
  name:
    name part: Abdul-M., Mohammad Saad
    role:
      role term: creator
  name:
    name part: International Islamic University Malaysia
    name part: Department of Basic Medical Sciences
  genre: Theses, IIUM local
  origin info:
    place:
      place term: my
    place:
      place term: Kuantan, Pahang
    publisher: Kulliyyah of Medicine, International Islamic University Malaysia
    date issued: 2010
  language:
    language term: eng
  physical description:
    extent: xvii, 142 leaves : ill. ; 30 cm.
  abstract: Hepatitis C virus (HCV) is a member of the family Flaviviridae (Flamm, S. L., 2003). HCV has 6 major genotypes. HCV is a global disease which has been described by WHO as a “viral time bomb”. It is estimated that about 170 million people, 3% of the world's population are infected by HCV. HCV is frequent in patients undergoing chronic haemodialysis (HD) (Fabrizi, F. et al., 1998), with prevalence between 8-10%. In Malaysia, the sero-prevalence of HCV is 1.6% (Theodore, Sy and Jamal, M. Mazen, 2006), sero-prevalence rates, range from 3% in blood donors to 85% in intravenous drug users (Sinniah, M. and Ooi, B.G. 1993). Measuring HCV viral load and identifying HCV genotype became standard procedures before starting anti-HCV therapy in France (Lefrère, Jean-Jacques et al., 2005) and other countries. The purpose of measuring viral load is to follow up the response to anti-HCV therapy (Yoon, Joonho et al., 2007; Halfon, Philippe et al., 2006) and to follow up the natural course of the virus infection (Fabrizio, Fabrizi et al., 2000). The aim of this study is to elucidate the biological dynamics of HCV infection in patients with end stage renal disease undergoing maintenance haemodialysis, the effect of HD on alpha-interferon levels, the possible role of alpha-interferon on viral load, the difference in viral loads between the different genotypes and the effect of viral load on liver damage.In this study 27 genotyped HCV infected patients were recruited from haemodialysis clinics in Pahang. HCV infection in these patients has been screened by Enzyme-Linked Immunosorbent Assay and confirmed by RT-PCR. Patients' serum samples were taken before and after haemodialysis sessions three times, one month apart over a period of 3 months. The HCV viral load, plasma alpha-interferon levels and liver function tests were the specific tests performed. The viral load results will be compared with the patients' functional status of the liver and with the different HCV genotypes. The study …
  note: by Mohammad Saad Abdul-M.
  note: "A dissertation submitted in partial fulfilment of the requirements for the degree of Master of Medical Sciences" --On t. p.
  note: Abstract in English and Arabic.
  note: Thesis (MMDSC) -- International Islamic University Malaysia, 2010.
  note: Includes bibliographical references (leaves 127-142).
  subject:
    geographic code: a-my---
  subject:
    topic: Hepatitis C virus
    geographic: Malaysia Pahang
  subject:
    topic: Hepatitis C virus
    topic: Infections
    geographic: Malaysia Pahang
  subject:
    topic: Hemodialysis
    geographic: Malaysia Pahang
  classification: QR201.H46
  identifier: https://lib.iium.edu.my/mom/services/mom/document/getFile/8gxUGrn1emn44pzefMhqWrq1s9N7nAC420131129090653176
  record info:
    record content source: UIAM
    record creation date: 110318
    language of cataloging:
      language term: eng