rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Formulation and characterization of resiquimod loaded microsponges in topical gel formulation
  name:
    name part: Zaiter, Ahmad Mohamad
    role:
      role term: creator
  name:
    name part: International Islamic University Malaysia
    name part: Department of Pharmaceutical Technology
  genre: Theses, IIUM local
  origin info:
    place:
      place term: my
    place:
      place term: Kuantan, Pahang
    publisher: Kulliyyah of Pharmacy, International Islamic University Malaysia
    date issued: 2015
  language:
    language term: eng
  physical description:
    extent: xviii, 119 leaves : ill. ; 30cm.
  abstract: Microsponge is a polymeric drug delivery system composed of spherical particles ranged in micron size and loaded with active pharmaceutical ingredient. Microsponges have maximum residency on the skin and slow release rate. Resiquimod is a candidate drug to be entrapped in microsponge drug delivery system. Formulation of resiquimod loaded microsponges was done using oil in water emulsion solvent evaporation method. The method had two phases, organic and aqueous phase. Three types of solvent were used in organic phase along with four volumes. Dichloromethane (DCM), chloroform and ethyl acetate (EA) were the solvent in organic phase with the volumes were used 1, 2.5, 5, 10 mL. Different formulations of microsponges using different volumes of solvents were prepared. From twelve microsponges formulations, three were chosen to be incorporated in aqueous gel. Microsponges prepared by 2.5 mL of DCM, 1 mL of chloroform or 5 mL of EA were selected and coded as F1, F2 and F3. Microsponges were evaluated for % entrapment efficiency (EE), average particle size (PS), span value (SV), and % production yield (PY). For determination of % EE and quantification of resiquimod in skin and percutaneous penetration samples, two reversed phase high performance liquid chromatographic methods were developed and validated. Differential scanning calorimetry (DSC) was used to evaluate the physical nature of resiquimod in microsponges. For both unincorporated and incorporated microsponges in gels, field emission scanning electron microscopy (FESEM) and Fourier transform infrared spectroscopy (FTIR) were used. The release and drug disposition from microsponges gels were evaluated by Franz diffusion cells using human skin. The highest % EE was 47.05 ± 1.88 and observed at 1 mL of chloroform. In contrast, the lowest % EE 12.7 ± 3.9 resulted from using 10 mL of EA. The range of PS was from 38 ± 9.96 to 2.44 ± 1.14. The SV for all of formulations was less than 2, which was an indication of monodisper…
  note: by Ahmad Mohamad Zaiter
  note: Thesis (MSPHT)--International Islamic University Malaysia, 2015.
  note: Includes bibliographical references (leaves 86-95).
  subject:
    geographic code: a-my---
  subject:
    topic: Polymeric drug delivery systems
  classification: RS201.P65
  identifier: https://lib.iium.edu.my/mom/services/mom/document/getFile/p5HrA0aAfOB7JKYTCanEQc5LPaDYDYK520160407151204296
  record info:
    record content source: UIAM
    record creation date: 171213
    language of cataloging:
      language term: eng