rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: In vitro antibacterial, antifungal and skin cytotoxic activities of Alpinia javanica, A. galanga and A. conchigera
  name:
    name part: Khan, Farman Ullah
    role:
      role term: creator
  name:
    name part: International Islamic University Malaysia
    name part: Department of Pharmaceutical Technology
  genre: Theses, IIUM local
  origin info:
    place:
      place term: my
    place:
      place term: Kuantan, Pahang
    publisher: Kulliyah of Pharmacy, International Islamic University Malaysia
    date issued: 2016
  language:
    language term: eng
  physical description:
    extent: xv, 131 leaves : ill. ; 30cm.
  abstract: The genus Alpinia belongs to the family of Zingiberaceae. It is distributed in tropical Africa, Asia, and particularly in Southeast Asia. The study was conducted to evaluate the antimicrobial and skin cytotoxic activities of Alpinia javanica, Alpinia galanga and Alpinia conchigera extracts. The crude extracts of A. javanica, A. galanga and A. conchigera were evaluated for their antimicrobial activity against human dermatophytes, gram positive and gram negative bacteria, and multidrug/methicillin resistant Staphylococcus aureus (MRSA) by using Disk Diffusion assay. Minimum inhibitory concentrations (MICs), minimum bactericidal and fungicidal concentrations (MBC and MFC) of A. javanica, A. galanga and A. conchigera crude extracts were determined based on a broth micro-dilution method in 96-microwell plates. The acetoxychavicol acetate (ACA), which is the major compound in Alpinia, was analysed and identified by using thin layer chromatography (TLC) and high performance liquid chromatography (HPLC). The toxic or hazardous effects of Alpinia extracts on normal mouse fibroblast (NIH/3T3) and normal human epidermal keratinocytes - adult (NHEK-a) cell lines were assessed through MTT assay. Overall, all extracts of A. javanica, A. galanga and A. conchigera showed good antibacterial and antifungal activities. However, hexane extract from A. javanica rhizome demonstrated strongest antibacterial activity with inhibition zone of 26 ± 0 mm against Staphylococcus aureus. In general, rhizome extracts of A. galanga showed strongest antibacterial effect as compared to leaf extracts. Overall, all Alpinia extracts showed good antibacterial activities against multidrug/methicillin-resistant Staphylococcus aureus (MRSA), however hexane extract from rhizome of A. javanica demonstrated strongest antibacterial activity against all strains of MRSA, followed by dichloromethane (DCM) and methanol extracts. The antibacterial activity of hexane extract was 29 ± 0.60 mm against MRSA. Similarly, …
  note: by Farman Ullah Khan
  note: Thesis (MSPHT)--International Islamic University Malaysia, 2016.
  note: Includes bibliographical references (leaves 109-125).
  subject:
    geographic code: a-my---
  classification: RM409
  identifier: https://lib.iium.edu.my/mom/services/mom/document/getFile/y0uAly1WLwT5zZCdDcHZfzvg1RSdANqj20161121143246231
  record info:
    record content source: UIAM
    record creation date: 170926
    language of cataloging:
      language term: eng