Fabrication of Porous Zinc Doped Hydroxyapatite for bone implants /
Bioactive ceramics are class of materials that have capability of bonding directly to the host bone. Hydroxyapatite (HA) is a perfect substitute for natural bone owing to its excellent biocompatibility and properties close to that of human bone. HA bioceramics are available in dense and porous forms...
Saved in:
| Main Author: | |
|---|---|
| Format: | Thesis |
| Language: | English |
| Published: |
Kuala Lumpur:
Kulliyyah of Engineering, International Islamic University Malaysia,
2014
|
| Subjects: | |
| Online Access: | http://studentrepo.iium.edu.my/handle/123456789/4820 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| LEADER | 038410000a22002770004500 | ||
|---|---|---|---|
| 008 | 140217t2014 my a g m 000 0 eng t | ||
| 040 | |a UIAM |b eng | ||
| 041 | |a eng | ||
| 043 | |a a-my--- | ||
| 050 | 0 | 0 | |a R857.M3 |
| 100 | 1 | |a Naqshbandi, Abreeq Rashid | |
| 245 | 1 | |a Fabrication of Porous Zinc Doped Hydroxyapatite for bone implants / |c by Abreeq Rahid Naqshbandi | |
| 260 | |a Kuala Lumpur: |b Kulliyyah of Engineering, International Islamic University Malaysia, |c 2014 | ||
| 300 | |a xv, 98 leaves : |b ill. ; |c 30cm. | ||
| 502 | |a Thesis (MSMAT)--International Islamic University Malaysia, 2014. | ||
| 504 | |a Includes bibliographical references (leaves 85-97). | ||
| 520 | |a Bioactive ceramics are class of materials that have capability of bonding directly to the host bone. Hydroxyapatite (HA) is a perfect substitute for natural bone owing to its excellent biocompatibility and properties close to that of human bone. HA bioceramics are available in dense and porous forms. A number of porous HA ceramics have been developed for applications in both tissue engineering and drug delivery systems. Porous bodies are decomposable in human body and provide a surface for proliferation and growth of cells that are infiltrated from the surrounding tissues so that a new bone grows into the pores and prevent any movement or loosening of the implants. The applications of porous bioceramics however, are limited since these cannot be used under load-bearing conditions due to their brittle nature and low fracture strength. A simple way of improving the strength of porous bioceramics is by doping HA powders with metal ions. In this work, zinc (Zn) was incorporated into HA since zinc is considered to be the most essential metal ion due to its involvement in bone formation in vitro and in vivo. Zinc is one of the bone growth factors and has a stimulatory effect on bone growth. In this study, Zn doped HA powders were synthesized via sol-gel technique. Morphological analysis of the powders by FESEM and TEM showed formation of agglomerates at an increased Zn concentration. XRD and FTIR results of powders confirmed the formation of HA as the main phase. The formation of β-TCP as the secondary phase occurred in 10% Zn doped HA. XRD results also revealed a decrease in crystallinity and crystal size with an increase in dopant concentration. These results were found to be in line with the results from particle size analyzer. The crystallite size of the powders decreased from 52 nm for Zn free HA to 40 nm for 10% ZnHA. Porous samples were prepared via polymeric sponge method using sol-gel derived HA powders. XRD results confirmed that the sintering process did not disrupt the HA phase. However, β-TCP was found to appear in porous 10% ZnHA. The morphology of the porous samples showed high degree of fusion and densification with an increase in Zn concentration. The density of the porous samples varied between 2.1-2.29 g/cm3. Incorporation of Zn was also found to improve the compressive test of porous samples. The compressive strength of the scaffolds was found to vary between 0.1-1.5 MPa and was highest for porous 10% ZnHA | ||
| 596 | |a 1 | ||
| 655 | 7 | |a Theses, IIUM local | |
| 690 | |a Dissertations, Academic |x Department of Manufacturing and Materials Engineering |z IIUM | ||
| 710 | 2 | |a International Islamic University Malaysia. |b Department of Manufacturing and Materials Engineering | |
| 856 | 4 | |u http://studentrepo.iium.edu.my/handle/123456789/4820 | |
| 900 | |a hab-zaj-ls-naw | ||
| 999 | |c 437033 |d 469628 | ||
| 952 | |0 0 |6 T R 000857 M3 N217F 2014 |7 0 |8 THESES |9 759530 |a IIUM |b IIUM |c MULTIMEDIA |g 0.00 |o t R 857 M3 N217F 2014 |p 00011294794 |r 2017-10-20 |t 1 |v 0.00 |y THESIS | ||
| 952 | |0 0 |6 TS CDF R 857 M3 N217F 2014 |7 0 |8 THESES |9 851878 |a IIUM |b IIUM |c MULTIMEDIA |g 0.00 |o ts cdf R 857 M3 N217F 2014 |p 00011294795 |r 2017-10-26 |t 1 |v 0.00 |y THESISDIG | ||