rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    non sort: The
    title: effect of flaxseed extract on the hepatic tissue injury in streptozotocin-induced diabetic rats
  name:
    name part: Abired, Ahmed Nuri Ahmed
    role:
      role term: creator
    role:
      role term: author
  name:
    name part: International Islamic University Malaysia
    name part: Department of Basic Medical Sciences
  genre: Theses, IIUM local
  origin info:
    place:
      place term: my
    date issued: 2016
  language:
    language term: eng
  physical description:
    extent: xiii, 73 leaves : illustrations ; 30cm.
  abstract: Prescribed medications used to treat diabetes do not adequately inhibit the development of its associated complications, furthermore, they may cause different side effects. Hence, there is a demand for alternative therapies to manage diabetes and its associated complications. This study aimed to evaluate the hepatoprotective effects of flaxseed extract in streptozotocin-induced diabetic rats. Diabetes mellitus was induced in Sprague-Dawley rats using a single injection of streptozotocin (60 mg/kg, intraperitoneally). The rats were divided into five groups of 8 animals each: Group NC, normal control rats; Group NF, normal rats treated with flaxseed extract (400 mg/kg); Group DC, diabetic control rats; Group DG, diabetic rats treated with glibenclamide (0.6 mg/kg); Group DF, diabetic rats treated with flaxseed extract (400 mg/kg); for 4 weeks. Body weight, liver relative weight, blood glucose level, liver enzymes and histopathological changes were determined in all experimental rats. Results showed a significantly increased relative liver weight, blood glucose, AST, ALT, GGT, ALP, and LDH levels, and decreased body weight, total protein, albumin, and globulin levels in DC group comparing to NC group (p<0.05). The disturbance of these parameters was ameliorated in DF and DG groups, however, the ameliorative effect was significant in DG group only (p<0.05). Examination of liver sections revealed congestion of central veins, degeneration of hepatocytes, and reduction glycogen granules in DC group. These pathological changes were ameliorated in the flaxseed extract and glibenclamide treated rats. In conclusion, our data showed that flaxseed extract represents a potential alternative treatment to control diabetes mellitus and its related hepatopathy.
  note: by Ahmed Nuri Ahmed Abired
  note: Thesis (MMDS)--International Islamic University Malaysia, 2016.
  note: Includes bibliographical references (leaves 66-73).
  subject:
    geographic code: a-my---
  classification: RC661.A47
  identifier: https://lib.iium.edu.my/mom/services/mom/document/getFile/uej0XsD3Z9LEDaEWfS7Ykl5LSMmm3AEE20160530121808960
  record info:
    record content source: UIAM
    record creation date: 160211
    language of cataloging:
      language term: eng