rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: In vivo antidiabetic studies of wogonin isolated from the leaves of Tetracera indica Merr
  name:
    name part: Afrin, Mehnaz
    role:
      role term: creator
  name:
    name part: International Islamic University Malaysia
    name part: Department of Basic Medical Sciences
  genre: Theses, IIUM local
  origin info:
    place:
      place term: my
    place:
      place term: Kuantan
    publisher: Kulliyyah of Pharmacy, International Islamic University Malaysia
    date issued: 2015
  language:
    language term: eng
  physical description:
    extent: xvi, 137 : ill. ; 30cm.
  abstract: The present thesis deals with the isolation, in vivo antidiabetic and toxicological evaluation of a flavonoid i.e. wogonin (5, 7-dihydroxy-8-methoxyflavone) isolated from the MeOH extract of Tetracera indica Merr. leaves (Dilleniaceae) (Mempelas paya in Malay) which is traditionally used in the management of diabetes in Malaysia. The thesis is therefore, presented in following three parts. Chemical investigation of the methanol extract (190 g) from the powdered leaves (1 kg) of T. indica resulted in the isolation of a desirable flavonoid i.e., wogonin (4.5 g). Isolation of the wogonin was carried out in three steps: multiple extractions with MeOH, fractionation using column chromatography and purification using recrystallization techniques with different polar solvents. Its structure was elucidated by spectroscopic analysis, mainly 1H-NMR, 13C-NMR, MASS, IR and UV techniques as well as comparison of the spectral data was made with those reported in the literatures for the same compound. In vivo antidiabetic study of wogonin was carried out using Sprague-Dawley rats (diabetic as well as normal) at three different concentrations (1, 5 and 25 mg/kg b.w.) At 5 and 25 mg/kg b.w., wogonin was found to exhibit significant anti-hyperglycaemic activity (p<0.05) in alloxan induced diabetic rats. In normal rats, no hypoglycaemic activity was observed at all the concentrations, when compared with +ve and –ve controlled groups. The antidiabetic activity was found to be comparable with glibenclamide (GLBC) (p<0.05), a known oral hypoglycemic agent (5 mg/kg b.w.). In vivo toxicological study was performed using the same strain of rats at two different concentrations (5 and 25 mg/kg b.w.) for continuous 15 days. During the study period no abnormal activity and mortality were observed. Histopathology of kidney, liver and pancreas of both normal and diabetic treated rats demonstrated normal and improved condition when compared to diabetic control group. The present study was also car…
  note: by Mehnaz Afrin
  note: Thesis (MSPHA)--International Islamic University Malaysia, 2015.
  note: Includes bibliographical references (leaves 115-129)
  subject:
    geographic code: a-my--
  classification: RC661.H4
  identifier: https://lib.iium.edu.my/mom/services/mom/document/getFile/eSz35G2kMCrUVLSilMenCYgpNW8k1mBo20160630105803982
  record info:
    record content source: UIAM
    record creation date: 150812
    language of cataloging:
      language term: eng