rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Neuroprotective effects of Nigella Sativa seeds and Murraya Koenigii Leaves extracts in a two vessel occlusion rat model of Azheimer's disease
  name:
    name part: Azzubaidi, Marwan Saad Abdulrahman
    role:
      role term: creator
  name:
    name part: International Islamic University Malaysia
    name part: Kulliyyah of Medicine
  genre: Theses, IIUM local
  origin info:
    place:
      place term: my
    place:
      place term: Kuantan
    publisher: Kulliyyah of Medicine, International Islamic University Malaysia
    date issued: 2012
  language:
    language term: eng
  physical description:
    extent: xvi, 129 leaves : ill. ; 30cm.
  abstract: Nigella sativa seeds oil (NSO) and Murraya koenigii leaves (MKL) demonstrated robust antioxidant and anti-inflammatory activities in vitro and in vivo. Two vessel occlusion surgery (2VO) is an established rat model of Alzheimer's disease (AD) which causes chronic cerebral hypoperfusion resulting in oxidative stress and neuroinflammation. These events lead to neurodegenerative brain changes especially within CA1 region of the hippocampus where spatial memory neurons are situated. This experimental intervention study was designed to assess the potential neuroprotective effect of the two herbal plants extracts when given orally to experimental animals ten days before 2VO surgery and continued until the tenth week post 2VO. The assessment was based on cognitive, histopathological and electron microscopical brain tissue analyses. 80 rats were equally divided into 4 main groups namely sham control, 2VO, NSO+2VO and MKL+2VO groups. Each one of them was further subdivided according to the experimental protocol of Morris water maze (MWM) test into long-term memory (LTM) subgroups which underwent acquisition MWM trials before 2VO and were retested for LTM performance on the 10th postoperative week, while the other subgroups were only introduced to MWM during the 10th postoperative week. These subgroups were tested by short-term memory (STM) and working memory test (WMT) protocols in a row. 2VO induced significant LTM, STM and learning impairment in 2VO rat group as compared to sham control as well as NSO+2VO groups, whereas the attenuation of 2VO induced memory impairment achieved by MKL treatment was significantly lower than that of sham control and NSO+2VO groups. The brain tissue analyses included histopathological as well as Transmission Electron Microscopy (TEM) examinations. Light microscope histopathology revealed significantly higher number of viable hippocampal cells in sham control and NSO treated rats groups as compared to untreated 2VO and MKL treated groups. Simu…
  note: by Marwan Saad Abdulrahman Azzubaidi
  note: Abstract in English and Arabic.
  note: "A thesis submitted in fulfilment of the requirement for the degree of Doctor of Philosophy in Medical Sciences."--On t.p.
  note: Thesis (Ph.D)--International Islamic University Malaysia, 2012.
  note: Includes bibliographical references (leaves 116-129).
  subject:
    geographic code: a-my---
  subject:
    topic: Alzheimer's disease
    topic: therapy
  subject:
    topic: Alzheimer's disease
    topic: Treatment
  subject:
    topic: Black cumin
    topic: Therapeutic use
  subject:
    topic: Curry leaf tree
    topic: Therapeutic use
  classification: RC523
  identifier: https://lib.iium.edu.my/mom/services/mom/document/getFile/TmrOagUJNgTBp9hVEQkL5dFWOWwfUvyk20130919115513472
  record info:
    record content source: UIAM
    record creation date: 130131
    language of cataloging:
      language term: eng