rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Synthesis, characterization and biological studies of dithiocarbamate derivatives and their metal complexes
  name:
    name part: Rahima
    role:
      role term: creator
  name:
    name part: International Islamic University Malaysia
    name part: Department of Biotechnology
  genre: Theses, IIUM local
  origin info:
    place:
      place term: my
    place:
      place term: Kuantan, Pahang
    publisher: Kulliyyah of Science, International Islamic University Malaysia
    date issued: 2015
  language:
    language term: eng
  physical description:
    extent: xxvii, 276 leaves : ill. ; 30cm.
  abstract: Three N–monosubstituted dithiocarbamates [potassium phenylethyl dithiocarbamate (PEDTC), 2–phenylethanaminium phenylethyl dithiocarbamates (APEDTC), and 3–phenylpropyl dithiocarbamate (PPDTC)] and three N–disubstituted dithiocarbamates [potassium bis(2–hydroxyethyl) dithiocarbamte (HEDTC), sodium piperidine dithiocarbamate (PDTC) and sodium morpholine dithiocarbamate (MDTC)], four series of S–substituted dithiocarbamate derivatives from PEDTC, PPDTC, PDTC, and MDTC, and metal complexes of HEDTC and PEDTC were successfully synthesized and characterized. Nickel complexes derived from S2MPEDT and SNMPEDT were found to be disulfane ligands [1,2–bis(2–methylbenzyl)disulfane (B2MSS) and 1,2–bis(naphthalen–2–ylmethyl)disulfane (BNMSS)]. Imidazolidine–2–thione (NAPH2T) was obtained unexpectedly from the attempt to synthesize N–monosubstituted dithiocarbamate. All compounds possessed yields ranging from low to good. Nineteen structures were elucidated using single crystal X–ray diffraction analysis. S–substituted derivatives were synthesized from nucleophilic substitution of sodium or potassium dithiocarbamates with a variety of alkyl halides (benzyl chloride, 2–methylbenzyl chloride, 3–methylbenzyl chloride, 4–methylbenzyl chloride, and 1–chloromethylnaphtalene). The antimicrobial activities of all the N–, S–substituted dithiocarbamates and their complexes were investigated against four gram–positive bacteria (B. cereus, S. aureus, S. epidermidis, and S. pyogenes), four gram–negative bacteria (E. coli, K. pneumonia, P. aeruginosa, and S. typhimurium), and fungi (C. albicans). It was found that the S–substituted derivatives were active selectively against S. epidermidis and S. pyogenes. For S. epidermidis, the inhibition zones (mm) were 7 ± 0 (S2MPEDT), 9 ± 0 (S3MPEDT), 8 ± 0.6 (SNMPEDT), (9 ± 0) SBPPDT, (9 ± 0) S3MPPDT, (8 ± 0) S4MPPDT, and (11 ± 0) S3MPDT. The inhibition zones (mm) of 7 ± 0.6 (SBPEDT), 8 ± 0.6 (S2MPEDT), 10 ± 1.1 (S3MPEDT), 8 ± 0.6 (S4MPEDT), 8 ± 0 (SNMPED…
  note: by Rahima
  note: Thesis (MSBSC)--International Islamic University Malaysia, 2015.
  note: Includes bibliographical references (leaves 210-225).
  subject:
    geographic code: a-my---
  classification: QD305.T45
  identifier: https://lib.iium.edu.my/mom/services/mom/document/getFile/VjfVgmJouVFYTRFu9ctmZ5tmTSFtObdY20160322134917458
  record info:
    record content source: UIAM
    record creation date: 151120
    language of cataloging:
      language term: eng