rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Skin microvasculature in different types of diabetic foot ulcer
    sub title: a comparative study
  name:
    name part: Hazulin Mohd Radzuan
    role:
      role term: creator
  name:
    name part: International Islamic University Malaysia
    name part: Department of Basic Medical Sciences
  genre: Theses, IIUM local
  origin info:
    place:
      place term: my
    place:
      place term: Kuantan
    publisher: Kulliyyah of Medicine, International Islamic University Malaysia
    date issued: 2013
  language:
    language term: eng
  physical description:
    extent: xvii, 97 leaves : ill. ; 30cm.
  abstract: Morphological changes affecting endothelial cells of skin microvasculature in diabetic foot ulcer (DFU) may indicate microcirculatory dysfunction and subsequently leads to poor healing of ulcer. In this study, I have analysed 42 subjects, involving 10 controls, 16 patients with neuropathic DFU and 16 patients with neuroischaemic DFU. The specimens were taken by using skin punch biopsy and routinely processed for light microscopy. I have calculated and measured the mean endothelial cell count (ECC), endothelial cell thickness (ECT) and luminal area:outer vessel area ratio in percentage (LA) from 3 selected arterioles and capillaries in each slide of every patient. There were significant decrement in ECC and LA among the diseased group as compared to the controls, F (2, 39) = 9.20, p = 0.01 and F (2, 39) = 17.54, p < 0.05. While the ECT of the diseased group were significantly higher than the controls, F (2, 39) = 66.11, p < 0.05. The Tukey post-hoc comparisons indicate that the ECC between neuropathic and neuroischemic group was insignificant, but the ECT and LA revealed significant differences as p < 0.05. In conclusion, the decrement of ECC and LA, and the increment of ECT among different types of DFU patients show endothelial cells adaptation towards diabetic state, thus affecting the patency of skin microvasculature and may signify different prognosis in different types of DFU.
  note: by Hazulin Mohd Radzuan
  note: Thesis (MMDSc)--International Islamic University Malaysia, 2013.
  note: Includes bibliographical references (leaves 82-92).
  subject:
    geographic code: a-my---
  classification: RD563
  identifier: https://lib.iium.edu.my/mom/services/mom/document/getFile/nBWrZfqngSjObSimz5PLkksh7Oypx1c720131107110823486
  record info:
    record content source: UIAM
    record creation date: 130715
    language of cataloging:
      language term: eng