rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Synergistic effect of peppermint oil and black seed oil loaded into alginate beads for treating irritable bowel syndrome in animal model
  name:
    name part: Azad, Md. Abul Kalam
    role:
      role term: creator
    role:
      role term: author
  name:
    name part: International Islamic University Malaysia
    name part: Kulliyyah of Pharmacy
  genre: Theses, IIUM local
  origin info:
    place:
      place term: my
    date issued: 2021
  language:
    language term: eng
  physical description:
    extent: xx, 232 leaves : colour illustrations ; 30cm.
  abstract: Black seed oil (BSO) have traditional claims and scientific evidences for therapeutic and pharmacological values. Similarly, peppermint oil (PO) has been used for a long time as a therapeutic agent for stomach related diseases. In conjunction with their therapeutic benefit, they have become an interest in utilization in pharmaceutical use. The key objective and major challenge of this study was to develop a pH sensitive BSO and PO loaded alginate bead as an intestinal release matrix system designed to release in the intestine without releasing the drug in the gastric fluid. To overcome these challenges, organic-solvent-free, green, and environmentally friendly electrohydrodynamic atomization (EHDA) technique was employed to prepare BSO and PO loaded alginate beads. This process enabled the formulation of small size and uniform beads with suitable diffusion, and swelling characteristic resulting in process performance enhancement. The current study deals with the development, optimization, and in vitro characterization of BSO and PO beads in different aspects like emulsion stability (ES), particle size distribution, zeta potential, yield percentage (Y%), physical appearance i.e. scanning electron microscopy (SEM), encapsulation efficiency (EE%), quantification of thymoquinone and menthol, shape, weight uniformity, ex vivo mucoadhesive properties, in vitro drug release profile, and gastrointestinal tract (GIT) beads distribution. Prior to that, the compatibility was tested using attenuated total reflectance-Fourier-transform infrared spectroscopy (ATR-FTIR) and differential scanning calorimetry (DSC). Then the optimized formulation was administered to evaluate the therapeutic efficacy as an anti-inflammatory effect of BSO and PO loaded beads in irritable bowel syndrome (IBS) in mustard oil (MO)-induced Sprague-Dawley rats. The results indicate that the voltage and flow rate have significant influenced on beads size and sphericity factor as well as on encapsulation eff…
  note: by Md. Abul Kalam Azad
  note: Thesis (Ph.D)--International Islamic University Malaysia, 2021.
  note: Includes bibliographical references (leaves 191-228).
  subject:
    geographic code: a-my---
  subject:
    topic: Irritable colon
    topic: Alternative treatment
  subject:
    topic: Gastrointestinal system
    topic: Diseases
  subject:
    topic: Peppermint oil
    topic: Therapeutic use
  classification: RC862.I77
  identifier: http://studentrepo.iium.edu.my/handle/123456789/10723
  record info:
    record content source: UIAM
    record creation date: 210921
    language of cataloging:
      language term: eng