rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    non sort: The
    title: study of leptin and leptin receptor expression in infiltrating ductal carcinoma of the breast
  name:
    name part: Al-Shibli, Saad Mohammed AbdulRazzaq
    role:
      role term: creator
    role:
      role term: author
  name:
    name part: International Islamic University Malaysia
    name part: Kulliyyah of Medicine
  genre: Theses, IIUM local
  origin info:
    place:
      place term: my
    date issued: 2017
  language:
    language term: eng
  physical description:
    extent: xvi, 124 leaves : illustrations ; 30cm.
  abstract: Leptin is a multifunctional hormone produced mainly by the white adipocyte. For leptin to act, it needs to bind to its receptor. leptin and its receptor activity is correlated with breast carcinogenesis. The main aim of this study is to investigate the correlation between leptin/leptin receptor and the clinico-pathological features of breast cancer. Fifty one women with breast cancer were included in this study while the control group was 40 women with negative mammogram for breast cancer. Demograghic data, anthropometric measurements and blood samples for serum leptin measurement were taken from all the participants. Leptin level was compared in patients with that of the control. Pre and postoperative leptin levels were studied. We investigated the correlation of leptin and its receptor expression with the clinico-pathological features of the breast cancer through the immunohistochemistry. We localized leptin and its receptor intracellularly using transmission electron microscope (TEM) immunocytochemistry. This study investigates the role of leptin in breast carcinogenesis in many aspects and investigates the subcellular localization of leptin and its receptors in the breast cancerous cells and comparing it with that of normal breast tissue using TEM. No significant differences in leptin levels were obtained in the study group among marital status, parity and menopausal status. Leptin level was significantly high in the study group as compared with the control group; no significant difference was found in leptin levels between the preoperative and postoperative measurements. We found that the majority of the breast cancer cells studied, stained positively for leptin and leptin receptors with co-expression of leptin and its receptors. No significant correlation was found between leptin/leptin receptors expression with the race, menopausal status, lymph node metastasis, estrogen receptor expression, progesterone receptor expression, HER2 expression and tumor size. Ma…
  note: by Saad Mohammed AbdulRazzaq Al-Shibli
  note: Thesis (Ph.D)--International Islamic University Malaysia, 2017.
  note: Includes bibliographical references (leaves 97-110).
  subject:
    geographic code: a-my---
  classification: QP572.L48
  identifier: https://lib.iium.edu.my/mom/services/mom/document/getFile/7kfYal62p52UpIHvqPzFJDTK367WhHBo20180125160322052
  record info:
    record content source: UIAM
    record creation date: 171023
    language of cataloging:
      language term: eng