rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Preparation and characterization of polycaprolactone-collagen loaded gentamicin sulphate nanofibers by electrospinning
  name:
    name part: Abdul Hakim bin Abdul Razak
    role:
      role term: creator
    role:
      role term: author
  name:
    name part: International Islamic University Malaysia
    name part: Department of Biotechnology
  genre: Theses, IIUM local
  origin info:
    place:
      place term: my
    date issued: 2018
  language:
    language term: eng
  physical description:
    extent: xii, 70 leaves : colour illustrations ; 30cm.
  abstract: Combination of synthetic and natural polymers have broadened the scope for development of nanofibrous scaffolds. This combination was believed could promote greater properties of nanofibers to be used in the field of tissue engineering. Indeed, the latest advancement in the nanofiber production was to incorporate therapeutically agent in order to improve its functions as a drug carrier to target area. The effective scaffolds should have properties and delivery characteristics that are suitable for specific wound types with convenience property to the patient and at rational cost. Thus some modification of the physical characteristics of the wound dressing systems is essential. In this study, nanofibers from polycaprolactone (PCL)/collagen loaded with gentamicin sulphate were prepared using electrospinning technique. Scanning electron microscopy (SEM) micrograph of PCL/Collagen (3:1) nanofibers showed smooth and fine fibers with average fibers diameter 121.37 ± 18.02 nm and for PCL/collagen (3:1) loaded 1% gentamicin sulphate showed smooth, finer and less beads formation with average fiber diameters 123.66 ± 34.20 nm. The increment of gentamicin sulphate concentration leads to the increase fiber diameter. Moreover, the drug release revealed sustained release patterns for nanofibers loaded 1%, 3% and 5% gentamicin with the highest release percentage of 5% gentamicin concentration. The MTT assay demonstrated high viability of normal human fibroblast cells on PCL/collagen nanofibers with and without gentamicin sulphate after 5 days. The antibacterial study for PCL/Collagen loaded gentamicin sulphate nanofiber shown high inhibition for both bacterial strain, gram negative escherichia coli and gram positive staphylococcus aureus for all PCL/collagen loaded gentamicin sulphate nanofibers for 3 days of incubation. Therefore, PCL/collagen loaded gentamicin sulphate nanofiber can be potential for skin tissue engineering
  note: by Abdul Hakim bin Abdul Razak
  note: Thesis (MSBSC)--International Islamic University Malaysia, 2018.
  note: Includes bibliographical references (leaves 56-61).
  subject:
    geographic code: a-my---
  classification: R857.T55
  identifier: https://lib.iium.edu.my/mom/services/mom/document/getFile/LewEXSQfcAbJ3n2yuuvZ7kROMyrD6RNs20190723110348971
  record info:
    record content source: UIAM
    record creation date: 181213
    language of cataloging:
      language term: eng