rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Core-shell Ag@Pt metalic nanoparticles as a targeted drug carrier for cancer treatment
  name:
    name part: Chowdhury, Silvia
    role:
      role term: creator
    role:
      role term: author
  name:
    name part: International Islamic University Malaysia
    name part: Department of Mechatronics Engineering
  genre: Theses, IIUM local
  origin info:
    place:
      place term: my
    date issued: 2017
  language:
    language term: eng
  physical description:
    extent: xxv, 231 leaves : illustrations ; 30cm.
  abstract: Cancer is a complicated disease for which finding cure presents challenges. In recent decades new ways to treat cancer are being sought; one being nanomedicine which manipulates nanoparticles to target a cancer and release drugs directly to the cancer cells. A number of cancer treatments based on nanomedicine are under way and mostly are in preclinical trials owing to challenges in administration, safety, and effectiveness. One new method for drug delivery is the use of core-shell (metal-metal) nanoparticles, which has the potential to deliver drugs via light activation. In this study, a comparative study of the effects were carried out on Vero cell, a normal cell line. Results showed that, the two type of extracts inhibits growth of MCF-7 cell at varying degrees, but on the other hands, that have much less effect on Vero cell. Extracts, identified using Raman Spectroscopy shows peaks at 1349 cm-1, 944 cm-1 and 841 cm-1 indicating the presence of Tyr, Try and Gly. In addition, UV-vis analysis showed peaks in the range of 260 to 280 nm, inferring the presence of Tyr and Try, whereas the highest peak, 3.608 at 230 nm indicates the presence of peptide bond. In order to synthesis core-shell Ag@Pt NPs as photovoltaic drug carrier, the process parameters of AgNPs, Ag@Pt NPs and drug loaded Ag@Pt NPs synthesis has been statistically optimized by first executing One-Factor-At-a-Time (OFAT) strategy on three important parameters, this was followed by executing CCD design of experiments and ANN, to find the optimized parameters and the interactions among them, for maximal NPs production. The NPs sample was then characterized by FESAM, TEM, HRTEM, FTIR and UV-vis analysis. The performance test of peptide coated Ag@Pt NPs characterization was done by checking the drug releasing ability using with and without UV together with checking the biological interaction with MCF 7, breast cancer cell. Results showed that, the optimal and maximal of AgNPs production condition for both ANN…
  note: by Silvia Chowdhury
  note: Thesis (MSMCT)--International Islamic University Malaysia, 2017.
  note: Includes bibliographical references (leaves 209-225).
  subject:
    geographic code: a-my---
  classification: TA418.9.N35
  identifier: http://studentrepo.iium.edu.my/handle/123456789/4424
  record info:
    record content source: UIAM
    record creation date: 170516
    language of cataloging:
      language term: eng