Effect of previous cytomegalovirus infection on response to influenza vaccination in the elderly in Kuantan /
Disease burden from the Malaysian elderly population is increasing as demographics shifts towards longer life expectancy. It is increasingly evident that immunosenescence is the central process in many age-related illnesses. Latent human cytomegalovirus (HCMV) infection had been shown to change the...
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| Main Author: | |
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| Format: | Thesis |
| Language: | English |
| Published: |
Kuantan, Pahang :
Kulliyah of Medicine, International Islamic University Malaysia,
2017
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| Subjects: | |
| Online Access: | Click here to view 1st 24 pages of the thesis. Members can view fulltext at the specified PCs in the library. |
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| LEADER | 031280000a22003010004500 | ||
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| 008 | 170818s2017 my a f m 000 0 eng d | ||
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| 041 | |a eng | ||
| 043 | |a a-my--- | ||
| 050 | 0 | 0 | |a RC136.8 |
| 100 | 0 | |a Mohd Asyraf bin Abdull Jalil, |e author | |
| 245 | 1 | 0 | |a Effect of previous cytomegalovirus infection on response to influenza vaccination in the elderly in Kuantan / |c by Mohd Asyraf bin Abdull Jalil |
| 264 | 1 | |a Kuantan, Pahang : |b Kulliyah of Medicine, International Islamic University Malaysia, |c 2017 | |
| 300 | |a xvii, 104 leaves : |b illustrations ; |c 30cm. | ||
| 336 | |2 rdacontent |a text | ||
| 347 | |2 rdaft |a text file |b PDF | ||
| 502 | |a Thesis (MMDS)--International Islamic University Malaysia, 2017. | ||
| 504 | |a Includes bibliographical references (leaves 89-94). | ||
| 520 | |a Disease burden from the Malaysian elderly population is increasing as demographics shifts towards longer life expectancy. It is increasingly evident that immunosenescence is the central process in many age-related illnesses. Latent human cytomegalovirus (HCMV) infection had been shown to change the immune system in similar ways to aging, by causing chronic antigenic stress. However, direct evidence on the impact of such changes on health remains contentious due to limited data, variable population backgrounds and individual responses to HCMV. In this study among 59 elderly people in Kuantan, the impact of host HCMV control (measured using HCMV IgG level) on immunosenescence was assessed using Influenza vaccination response via haemagglutination inhibition (HI) assay. A criterion of ≥ fourfold rise in titre and a titre of ≥ 40 was used as an indicator for good response. Effect of chronic co-morbidities and history of significant infection was also studied as contributing factors. It was found that high HCMV IgG levels (> 90 RU/ml) was significantly associated with lower response rate to three vaccine strains (χ2(1) = 6.720, p = 0.010). In a binary logistic regression analysis, HCMV IgG levels, age and diabetes all significantly predicted the likelihood to response to overall three vaccine strains, but not to each individual strain. In conclusion, poor control of latent HCMV infection only partially affects Influenza vaccination response in the elderly. | ||
| 596 | |a 1 6 | ||
| 655 | 7 | |a Theses, IIUM local | |
| 690 | |a Dissertations, Academic |x Department of Basic Medical Sciences |z IIUM | ||
| 710 | 2 | |a International Islamic University Malaysia. |b Department of Basic Medical Sciences | |
| 856 | 4 | |u https://lib.iium.edu.my/mom/services/mom/document/getFile/qLeNDBP7nMEBI3DgWK2MWYDwwtb2M5Oq20171127154202849 |z Click here to view 1st 24 pages of the thesis. Members can view fulltext at the specified PCs in the library. | |
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