rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Effect of previous cytomegalovirus infection on response to influenza vaccination in the elderly in Kuantan
  name:
    name part: Mohd Asyraf bin Abdull Jalil
    role:
      role term: creator
    role:
      role term: author
  name:
    name part: International Islamic University Malaysia
    name part: Department of Basic Medical Sciences
  genre: Theses, IIUM local
  origin info:
    place:
      place term: my
    date issued: 2017
  language:
    language term: eng
  physical description:
    extent: xvii, 104 leaves : illustrations ; 30cm.
  abstract: Disease burden from the Malaysian elderly population is increasing as demographics shifts towards longer life expectancy. It is increasingly evident that immunosenescence is the central process in many age-related illnesses. Latent human cytomegalovirus (HCMV) infection had been shown to change the immune system in similar ways to aging, by causing chronic antigenic stress. However, direct evidence on the impact of such changes on health remains contentious due to limited data, variable population backgrounds and individual responses to HCMV. In this study among 59 elderly people in Kuantan, the impact of host HCMV control (measured using HCMV IgG level) on immunosenescence was assessed using Influenza vaccination response via haemagglutination inhibition (HI) assay. A criterion of ≥ fourfold rise in titre and a titre of ≥ 40 was used as an indicator for good response. Effect of chronic co-morbidities and history of significant infection was also studied as contributing factors. It was found that high HCMV IgG levels (> 90 RU/ml) was significantly associated with lower response rate to three vaccine strains (χ2(1) = 6.720, p = 0.010). In a binary logistic regression analysis, HCMV IgG levels, age and diabetes all significantly predicted the likelihood to response to overall three vaccine strains, but not to each individual strain. In conclusion, poor control of latent HCMV infection only partially affects Influenza vaccination response in the elderly.
  note: by Mohd Asyraf bin Abdull Jalil
  note: Thesis (MMDS)--International Islamic University Malaysia, 2017.
  note: Includes bibliographical references (leaves 89-94).
  subject:
    geographic code: a-my---
  classification: RC136.8
  identifier: https://lib.iium.edu.my/mom/services/mom/document/getFile/qLeNDBP7nMEBI3DgWK2MWYDwwtb2M5Oq20171127154202849
  record info:
    record content source: UIAM
    record creation date: 170818
    language of cataloging:
      language term: eng