rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Synthesis and computational studies of sydnone-based derivatives as potential anti-inflammatory agents
  name:
    name part: Abdualkader, Abdualrahman M.
    role:
      role term: creator
    role:
      role term: author
  name:
    name part: International Islamic University Malaysia
    name part: Kulliyyah of Pharmacy
  genre: Theses, IIUM local
  origin info:
    place:
      place term: my
    date issued: 2017
  language:
    language term: eng
  physical description:
    extent: xxv, 341 leaves : illustrations ; 30cm.
  abstract: Various literature sources have documented that sydnones are important bioactive molecules with a wide spectrum of activities involving the anti-proliferative and anti-inflammatory actions. Phenyl styrylketones and their derivatives as members of the chalcone family have also been reported as significant biological agents. The current study was initiated to evaluate in vitro cytotoxic and anti-inflammatory activity of sydnone-based compounds including some novel sydnone-styrylketone hybrids. The classical cyclodehydration of N-nitroso amino acids was applied in the preparation of the sydnone ring. Aldol condensation was utilized to join two sydnone rings by a styrylketone linker. Compounds identity was confirmed using FTIR, NMR and MS spectroscopy. MTT assay was used to evaluate the cytotoxicity of the synthesized compound. ELISA test was performed to investigate the COX-1/COX-2 inhibitory activity. The binding of sydnones with COX enzymes was examined by Glide docking and the Molecular Mechanics-Generalized Born Surface Area (MM-GBSA). The drug-likeness scores and membrane permeability of the compounds were also in silico predicted. Twenty-five sydnone-containing compounds were synthesized. Compounds 46-48 and 56-58 were reported as new sydnone derivatives. Compounds 61-63 were synthesized as novel structures containing two sydnone rings linked via α,β-unsaturated ketone. The structure of the synthesized compounds was confirmed by FTIR, 1H NMR, 13C NMR and ToF-MS analyses. All compounds exhibited low cytotoxicity especially against normal cell lines (IC50 in the range of mM). Only compound 45 had a significant antiproliferative activity against prostate (IC50 = 42 μM) and breast (IC50 = 63 μM) cancer cell lines. The in vitro COX inhibition assay showed varied activity. Compounds 47, 51, 58 and 63 showed the most potent COX inhibitory effect at a concentration of 200 μM. Selectivity index showed that only compound 63 was a selective COX-2 inhibitor. Acetylation of t…
  note: by Abdualrahman M. Abdualkader
  note: Thesis (Ph.D)--International Islamic University Malaysia, 2017.
  note: Includes bibliographical references (leaves 204-221).
  subject:
    geographic code: a-my---
  classification: RM405
  identifier: https://lib.iium.edu.my/mom/services/mom/document/getFile/OgMQAmbugzMVYIn8fq4swDw7b3s8QPCK20180115114814610
  record info:
    record content source: UIAM
    record creation date: 171120
    language of cataloging:
      language term: eng