rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    non sort: A
    title: comparative study among different carriers to enhance the bioavailability of aceclofenac via proniosomal system
  name:
    name part: Sammour, Rana Mhd Farid
    role:
      role term: creator
    role:
      role term: author
  name:
    name part: International Islamic University Malaysia
    name part: Kulliyyah of Pharmacy
  genre: Theses, IIUM local
  origin info:
    place:
      place term: my
    date issued: 2020
  language:
    language term: eng
  physical description:
    extent: xix, 184 leaves : colour illustrations ; 30cm.
  abstract: In the contemporary medical model world, the proniosomal system has served as a new drug delivery system that significantly enhances the bioavailability of drugs with low water solubility. Aceclofenac (ACE), a potent non-steroidal anti-inflammatory drug is used to relieve pain and inflammation in osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. However, it is characterised by low bioavailability that limited its use. Hence, the application of the proniosomal system can improve the bioavailability of ACE. The present study was intended to develop an optimised proniosomal ACE formula by the use of different carriers. Three formulations of proniosomes were prepared by the slurry method using the 100 mg of ACE, 500 mg of Span 60, 250 mg of cholesterol with 1300 mg of different carriers, i.e., glucose (FN1), maltodextrin (FN2), and mannitol (FN3). The prepared proniosomes were characterised by fourier transform infrared analysis to reveal the compatibility of the drug chosen with the ingredient added. Meanwhile, the powder X-ray diffractometry confirmed the amorphous phase of the prepared proniosomes, and the surfactant layer was observed by scanning electron microscopy. Hydrated proniosomes yielded niosomes with high EE (84%) and 100% drug content. No significant differences (p > 0.05) in entrapment efficiency (EE) of FN1, FN2, and FN3 (82±0.5%, 84±0.66%, and 84±0.34%, respectively) were observed and formulations were used as such for further in vitro and in vivo evaluations. During in vitro drug release studies, the dissolved drug was found to be 42% for the pure drug, while 70%, 17% 30% for FN1, FN2, and FN3 respectively at 15 min. After 24 h, the pure drug showed a maximum of 50 % release while 94%, 80%, 79% drug release were observed after 24 h for FN1, FN2, and FN3, respectively. A comparison between the two methods was made, and the results revealed the appropriateness of the paddle method. The in vivo study conducted using albino rats showed enha…
  note: by Rana Mhd Farid Sammour
  note: Abstracts in English and Malay.
  note: "A thesis submitted in partial fulfilment of the requirement for the Degree of Doctor of Philosophy in Pharmaceutical Sciences (Pharmaceutical Technology)."--On title page.
  note: Thesis (Ph.D)--International Islamic University Malaysia, 2020.
  note: Includes bibliographical references (leaves 171-181).
  subject:
    geographic code: a-my---
  subject:
    topic: Drug delivery systems
  subject:
    topic: Drug carriers (Pharmacy)
  subject:
    topic: Diclofenac
    topic: Bioavailability
    topic: Testing
  classification: RS199.5
  identifier: http://studentrepo.iium.edu.my/handle/123456789/10759
  record info:
    record content source: UIAM
    record creation date: 211111
    language of cataloging:
      language term: eng