rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Thermoreversible in situ gelling formulation of carbamazepine for intranasal delivery
    sub title: preparation, characterization and ex-vivo study
  name:
    name part: Keithanchali, Mohananaidu
    role:
      role term: creator
    role:
      role term: author
  name:
    name part: Farahidah Mohamed
    role:
      role term: degree supervisor
  name:
    name part: Bappaditya Chatterjee
    role:
      role term: degree supervisor
  name:
    name part: International Islamic University Malaysia
    name part: Department of Pharmaceutical Technology
  genre: Theses, IIUM local
  origin info:
    place:
      place term: my
    date issued: 2020
  language:
    language term: eng
  physical description:
    extent: xvii, 125 leaves : colour illustrations ; 30cm.
  abstract: Carbamazepine (CBZ) is used to treat epilepsy and is an anti-convulsant requiring the drug to reach the brain to exert their pharmacological response. The presence of blood-brain barrier (BBB) poses a great challenge for any drugs to reach the receptors in the brain especially when the drugs are administered by oral route. Over the past decade, intranasal (IN) delivery has been increasingly considered as an alternative route of drug delivery. This is because the nasal mucosa has a large surface area and high blood flow that allows better bioavailability. However, this route poses high variability in drug absorption due to short retention time of dosage form on nasal mucosa complicated by naso-ciliary clearance mechanism. This research aims to investigate ability of a novel dosage form i.e. a thermoreversible in situ gelling system on absorption of CBZ via IN route. Briefly, a CBZ thermoreversible gel was developed by mixing 15-20% Poloxamer 407 (P407) with 0.15-0.25% τ-Carrageenan (ɩ-Cg) by cold method to 3% CBZ solution (weight ratio). The formulations takes liquid state when stored at 2-8 ̊ C and gel at nasal temperatures (32-34°С). The gelation temperature and pH for the in situ gels were 26-36 °C and 4.5-6.5 respectively. CBZ compatibility in formulation was determined by a developed ATR-FTIR method. Rheology study of the gel by a controlled (CR) ramp test showed pseudoplasticity and distinct shear-thinning with increasing shear stress. CT3 Texture analyzer was used to determine the mucoadhesion strength of the gel using goat nasal mucosa. Monopolymeric formulations containing 18% and 20% showed greater mucoadhesive strength (<300,000 dyne/cm²) as opposed to binary mixtures containing P407 and ɩ-Cg (T10-T18). In vitro was conducted with a dialysis membrane and formulations containing only P407 had greater release compared to those with both P407 and ɩ-Cg in 24h. Ex-vivo drug permeation study through goat nasal mucosa was done using Franz diffusion cell. Permeati…
  note: by Keithanchali Mohananaidu
  note: Abstracts in English and Arabic.
  note: "A thesis submitted in fulfilment of the requirement for the degree of Master in Pharmaceutical Sciences (Pharmaceutical Technology)." --On title page.
  note: Thesis (MSPHT)--International Islamic University Malaysia, 2020.
  note: Includes bibliographical references (leaves 113-124).
  subject:
    geographic code: a-my---
  identifier: http://studentrepo.iium.edu.my/handle/123456789/10332
  record info:
    record content source: UIAM
    record creation date: 210120
    language of cataloging:
      language term: eng