Pancreaticoduodenectomy for periampullary cancer in Sarawak : a 3-year survival analysis and factors affecting it /
Periampullary cancers incidence has been uprising worldwide which resulted in increasing morbidity and mortality. The distinct anatomy of that region often can give rise to different types of cancers. However, they are subjected to a common procedure – pancreaticoduodenectomy. The survivals after cu...
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| Main Author: | |
|---|---|
| Format: | Thesis |
| Language: | English |
| Published: |
Kuantan, Pahang :
Kulliyyah of Medicine, International Islamic University Malaysia,
2020
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| Subjects: | |
| Online Access: | Click here to view 1st 24 pages of the thesis. Members can view fulltext at the specified PCs in the library. |
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| LEADER | 040190000a22003730004500 | ||
|---|---|---|---|
| 008 | 210121s2020 my a f m 000 0 eng d | ||
| 040 | |a UIAM |b eng |e rda | ||
| 041 | |a eng | ||
| 043 | |a a-my--- | ||
| 100 | 1 | |a Tay, Yen Zhir, |e author | |
| 245 | 1 | |a Pancreaticoduodenectomy for periampullary cancer in Sarawak : |b a 3-year survival analysis and factors affecting it / |c by Tay Yen Zhir | |
| 264 | 1 | |a Kuantan, Pahang : |b Kulliyyah of Medicine, International Islamic University Malaysia, |c 2020 | |
| 300 | |a xii, 58 leaves : |b colour illustrations ; |c 30cm. | ||
| 336 | |2 rdacontent |a text | ||
| 337 | |2 rdamedia |a unmediated | ||
| 338 | |2 rdacarrier |a volume | ||
| 338 | |2 rdacarrier |a online resource | ||
| 347 | |2 rdaft |a text file |b PDF | ||
| 500 | |a Abstracts in English. | ||
| 500 | |a "A dissertation submitted in fulfilment of the requirement for the degree of Master of Sugery (General Surgery)." --On title page. | ||
| 502 | |a Thesis (MOS)--International Islamic University Malaysia, 2020. | ||
| 504 | |a Includes bibliographical references (leaves 47-50). | ||
| 520 | |a Periampullary cancers incidence has been uprising worldwide which resulted in increasing morbidity and mortality. The distinct anatomy of that region often can give rise to different types of cancers. However, they are subjected to a common procedure – pancreaticoduodenectomy. The survivals after curative resection varies geographically and multiple cohort studies has shown to give different factors affecting the survival of periampullary cancers. Therefore, this study is to determine the overall survival and to identify the sociodemographic, peri-operative and histopathological factors affecting periampullary cancers after pancreaticoduodenectomy in Sarawak. Retrospective collected demographic, clinical features, peri-operative parameters histopathological features of all patient with periampullary cancers who underwent pancreaticoduodenectomy from January 2013 till June 2018. Overall survival and 3-year survival probability are determined using Kaplan-Meier curve. The affecting factors are analysed cox regression for univariate and multivariate analysis. A total of 56 patients with median for overall survival is 17.43 months (SD 2.86 months). The 3-year survival rate of this cohort is 14.0%. Iban (P = 0.006) and other minorities ethic (P = 0.005) in Sarawak shown to have a poor prognosis. Pre-operative biliary drainage is the only factor with significant difference (P<0.001, 95% CI 0.091 – 0.748) in univariate and multivariate analysis. Operating duration (P=0.006) and numbers of packed red blood cells transfused (P=0.018) are also significantly affecting the survivals after adjustment. Marginal involvement (P =0.024) and tumour types (P=0.055) are the histopathological factors with worst prognosis. The periampullary cancer survival rates in Sarawak was seen less comparable to other region. Ethnicity had been known to be a significant predictor in overall survival from the socio-demographic characteristic. Pre-operative biliary drainage, number of packed red cell blood transfusion and operative time were important peri-operative factors with significantly worsened the survival. Tumour types and marginal involvement were also strongly associated with poorer survival probability. | ||
| 596 | |a 6 | ||
| 655 | 7 | |a Theses, IIUM local | |
| 690 | |a Dissertations, Academic |x Department of Surgery |z IIUM | ||
| 700 | 0 | |a Junaini Kasian, |e degree supervisor | |
| 700 | 0 | |a Nik Azim Nik Abdullah, |e degree supervisor | |
| 700 | 0 | |a Sahrol Azmi Termizi, |e degree supervisor | |
| 710 | 2 | |a International Islamic University Malaysia. |b Department of Surgery | |
| 856 | 4 | |u http://studentrepo.iium.edu.my/handle/123456789/10362 |z Click here to view 1st 24 pages of the thesis. Members can view fulltext at the specified PCs in the library. | |
| 900 | |a sz to ash | ||
| 999 | |c 441383 |d 472081 | ||
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