rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Characterization and optimization of bioactive compounds extracted from gum arabic via ultrasonic assisted technique
  name:
    name part: Mohammedelnour, Ahmed Adam Hassan
    role:
      role term: creator
    role:
      role term: author
  name:
    name part: Mirghani, Mohamed Elwathiq Saeed
    role:
      role term: degree supervisor
  name:
    name part: Kabbashi, Nassereldeen Ahmed
    role:
      role term: degree supervisor
  name:
    name part: Alam, Md. Zahangir
    role:
      role term: degree supervisor
  name:
    name part: International Islamic University Malaysia
    name part: Kulliyyah of Engineering
  genre: Theses, IIUM local
  origin info:
    place:
      place term: my
    date issued: 2020
  language:
    language term: eng
  physical description:
    extent: xv, 297 leaves : colour illustrations ; 30cm.
  abstract: Gum Arabic is a natural antioxidant, which comes from Acacia complex group of gums (ACGG). It is rich in dietary fibres and polyphenolics compounds that can support healthy living due to its antioxidant activity (AA). Despite its rich AA and medical benefits, the research on the ACGG antioxidant extraction has not received the attention it deserves from researchers and governments. Therefore, the aim of this study is to create an optimized extraction conditions that will enhance antioxidant activity and effectiveness. To achieve this aim, the first experiment was conducted to extract the ACGG active compounds using methanolic crude extraction (MCE) method, and to determine the physiochemical properties of the extracts, e.g. flavonoids, phenolic compounds, moisture content, pH, metal profile and amino acid profile. Meanwhile, the second experiment was carried out to optimize the methods and extraction conditions to improve the AA using DOE and PCA. The third experiment was conducted to study the antioxidant materials regarding crude extract and its active sub-fractions using the optimized conditions, and the last experiment was carried out to investigate the anti-inflammatory of the ACGG methanolic crude extracts and active fractions (MF and AF) on Albino rats (in-vivo) and the antiproliferative activity against breast adenocarcinoma (MCF-7), colon adenocarcinoma (HCT-116), and prostate cancer (PC3) cell lines using in-vitro assay. Results from the extraction indicated a significant number of flavonoid compounds and phenolic compounds (amongst others) in both ACGG (6540±3.46µg/100g) and PBMT from (2560±3.49µg/100g) to (2710±4.04µg/100g), using HPLC analysis. The individual flavonoid detected was quercetin. For the phenolic acids, the active compound were identified in both the ACGG and the Prebio-T were caffeic acids and ρ-coumaric, p-hydroxybenzoic, and ferulic acid with caffeic acid being the most predominant phenolic compounds in the ACGG (lateritic soil sample: 4…
  note: by Ahmed Adam Hassan Mohammedelnour
  note: Abstracts in English and Arabic.
  note: "A thesis submitted in fulfilment of the requirement for the degree of Doctor of Philosophy (Engineering)."--On title page.
  note: Thesis (Ph.D)--International Islamic University Malaysia, 2020.
  note: Includes bibliographical references (leaves 233-270).
  subject:
    geographic code: a-my---
  subject:
    topic: Bioactive compounds
  subject:
    topic: Medicinal plants
    topic: Analysis
  subject:
    topic: Acacia
  subject:
    topic: Ultrasonic testing
  classification: QK898.B54
  identifier: http://studentrepo.iium.edu.my/handle/123456789/10096
  record info:
    record content source: UIAM
    record creation date: 200623
    language of cataloging:
      language term: eng