Survival of lung cancer patient and its prognostic factor in a single centre at Hospital Tengku Ampuan Afzan, Kuantan Pahang, Malaysia 2020 /
Lung cancer is the commonest cancer with highest mortality worldwide. However, survival data is lacking in Malaysia. This study intended to determine the survival of our lung cancer patients and factors affecting its survival. All lung cancer patients confirmed by histology from 1st January 2014 to...
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| Format: | Thesis |
| Language: | English |
| Published: |
Kuantan, Pahang :
Kulliyyah of Medicine, International Islamic University Malaysia,
2020
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| Subjects: | |
| Online Access: | Click here to view 1st 24 pages of the thesis. Members can view fulltext at the specified PCs in the library. |
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| Summary: | Lung cancer is the commonest cancer with highest mortality worldwide. However, survival data is lacking in Malaysia. This study intended to determine the survival of our lung cancer patients and factors affecting its survival. All lung cancer patients confirmed by histology from 1st January 2014 to 31 December 2017 in Hospital Tengku Ampuan Afzan, Kuantan were recruited and their demographic data, ECOG performance status, staging and treatment were recorded. Survival time was defined in week from the date of histological diagnosis to the date of death. Kaplan-Meier curve was used to determine median overall survival and log-rank test was used to test the survival differences between each subgroup. Multivariate analysis using COX regression was used to determine factors affecting its survival. A total 170 patients were included for survival analysis. Median age was 63years old and majority were males (74%) and smokers (64%). Adenocarcinoma (74.7%) was the most common histology followed by squamous cell carcinoma (18.8%). Almost all patient present at stage 3 or 4 (98%) but majority had ECOG 0-2 (64.3%). Median overall survival was 28.7weeks. In the multivariate analysis, “supportive treatment” and “poor ECOG performance status” were independent predictors of death with the hazard ratio of 1.4 (95%CI 1.17 to 1.66) and 3.0 (95%CI 2.05 to 4.39) times respectively. In conclusion majority of lung cancer patients in Pahang presented with advanced disease with overall median survival of 28.7 weeks. Patients treated with supportive care and poor ECOG performance status were two independent poor prognostic factors for survival. Keywords: Lung cancer survival, HTAA, Pahang, Malaysia, median survival, 1year survival. |
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| Item Description: | Abstracts in English. "A dissertation submitted in fulfilment of the requirement for the degree of Master of Medicine (Internal Medicine)." --On title page. |
| Physical Description: | xi, 37 leaves : illustrations ; 30cm. |
| Bibliography: | Includes bibliographical references (leaves 31-33). |