rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Optimization of the process extraction and drug release of fish gelatin nanoparticles derived from tilapia (oreochromis spp)
  name:
    name part: Subara, Deni
    role:
      role term: creator
    role:
      role term: author
  name:
    name part: Irwandi Jaswir
    role:
      role term: degree supervisor
  name:
    name part: Ibrahim Ali Noor Batcha
    role:
      role term: degree supervisor
  name:
    name part: Ma’an Fahmi Rashid Al-khatib
    role:
      role term: degree supervisor
  name:
    name part: International Islamic University Malaysia
    name part: Kulliyyah of Engineering
  genre: Theses, IIUM local
  origin info:
    place:
      place term: my
    date issued: 2021
  language:
    language term: eng
  physical description:
    extent: xx, 145 leaves : illustrations ; 30 cm.
  abstract: Gelatin is one of the popular biopolymers used for food and pharmaceutical applications, given its capability to dissolve in aqueous environments and to form nanoparticles that enable the encapsulation of various active agents into stable products. On the other hand, coupled with these capabilities and recognition by the US Food and Drug Administration (FDA) authority, as Generally Recognized as Safe (GRAS) material, it has attracted growing interest and attention from researchers to produce gelatin nanoparticles toward encapsulating various food and pharmaceutical molecules. However, even though gelatin can be produced from mammalian and fish, it is quite challenging since all sources of gelatin nanoparticles in the market originate from mammalian gelatin, which is either bovine or porcine. Although the use of such gelatin as highlighted by Muslims, Jews, and other religious backgrounds is an issue. Furthermore, there are no publications regarding gelatin nanoparticles from fish gelatin published at this stage, which further adds to this problem. Therefore, this study aims to prepare and characterize fish gelatin nanoparticles (FGNPs) and FGNPs encapsulated with an active agent. Fish gelatin was first extracted from Tilapia fish skin employing a two-step desolvation method in producing FGNPs. The initial first desolvation step was optimized to obtain consistent high molecular weight at the gelatin concentration, temperature, centrifugation speed, and centrifugation time of 9%, 45 °C, 12000 xg, and 5 min, respectively. As an outcome from this work, a new method to produce significant FGNP properties consistently was created based on this step. A second desolvation step adopting the two-step desolvation method was also optimized in which significant factors were screened using Plackett-Burman experimental design, determining that the pH, acetone percentage, and glutaraldehyde volume were the significant factors. These factors were then optimized using factorial desig…
  note: by Deni Subara
  note: Abstracts in English and Arabic.
  note: "A thesis submitted in fulfilment of the requirement for the degree of Doctor of Philosophy (Engineering)." --On title page.
  note: Thesis (Ph.D)--International Islamic University Malaysia, 2021.
  note: Includes bibliographical references (leaves 124-139).
  subject:
    geographic code: a-my---
  subject:
    topic: Nanoparticles
    topic: Experiments
  subject:
    topic: Nanoparticle Drug Delivery System
  subject:
    topic: Tilapia
  subject:
    topic: Gelatin
  classification: TA418.9.N35
  identifier: http://studentrepo.iium.edu.my/handle/123456789/10988
  record info:
    record content source: UIAM
    record creation date: 220412
    language of cataloging:
      language term: eng