rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Development of pH-sensitive intranasal pregabalin gel and its pharmacokinetic evaluation
  name:
    name part: Muhammad Fathiy Mohd Mutalabisin
    role:
      role term: creator
    role:
      role term: author
  name:
    name part: Farahidah Mohamad
    role:
      role term: degree supervisor
  name:
    name part: Bappaditya Chatterjee
    role:
      role term: degree supervisor
  name:
    name part: A.B.M. Helal Uddin
    role:
      role term: degree supervisor
  name:
    name part: International Islamic University Malaysia
    name part: Department of Pharmaceutical Technology
  type of resource: text
  genre: theses
  genre: Theses, IIUM local
  origin info:
    place:
      place term: my
    date issued: 2021
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: print
    extent: xvi, 111 leaves : color illustrations. ; 30cm
  abstract: Intranasal drug delivery study is one of the promising methods of administration for central nervous system (CNS) drugs. It brings drugs directly to the brain through olfactory and trigeminal nerve. Any CNS drugs delivered via oral and intravenous have the potential to be delivered via nasal route. The main advantage of using intranasal route is to lessen the peripheral side effects by reducing the dose administered. Nasal route also brings its own challenge which is high mucociliary clearance rate. To solve the challenge, this study attempted an intranasal formulation using pH-sensitive polymer. Pregabalin was used as the model drug. Simple and robust analytical method for quantitation of Pregabalin has been developed and validated by using HPLC with UV detector. Validation criteria including specificity, linearity, limit of quantification (LOQ), limit of detection (LOD), precision and accuracy were met with International Conference on Harmonisation (ICH) standard. The method was linear with correlation coefficient (r2) 0.992 and limit of quantitation (LOQ) of 15 µg/ml. The method was applied to commercial Pregabalin (Pregabalin Sandoz) for assay analysis with 100.37 ±2.94 % accuracy. The formulation of pH-sensitive intranasal Pregabalin gel has been characterized by compatibility study, pHsol-gel and gelation time test, viscosity study, drug assay test, clarity test and in-vitro dissolution test. The formulation consists of 0.35%, 0.4% and 0.45% of Carbopol 940 with distilled water and Pregabalin. Compatibility study had shown no interaction within the formulation. From in-vitro dissolution test, there was no significant difference of drug release between the formulations (p>0.05) because of the slight difference in percentage of Carbopol 940 used. For bioanalytical method development, Aspirin had been used as the internal standard (IS) because it did not interact with Pregabalin and bioanalytical sample (brain and plasma). The HPLC parameters also had been optimi…
  target audience: specialized
  note: by Muhammad Fathiy Bin Mohd Mutalabisin
  note: Abstracts in English and Arabic.
  note: "A thesis submitted in fulfilment of the requirement for the degree of Master in Pharmaceutical Sciences (Pharmaceutical Technology)." --On title page.
  note: Thesis (MSPHT)--International Islamic University Malaysia, 2021.
  note: Includes bibliographical references (leaves 99-111).
  subject:
    geographic code: a-my---
  identifier: http://studentrepo.iium.edu.my/handle/123456789/11224
  record info:
    record content source: UIAM
    record creation date: 230214
    language of cataloging:
      language term: eng