Effects of hylocereus polyrhizus flesh on blood parameters in mice / Nur Mardhiya Darnalis
This study was conducted to determine the potential effects and toxicity associated with the use of Hylocereus Polyrhizus on blood parameters in mice. Two groups of six mice were given either the flesh with seed extract of HP (treatment group) or normal saline (control group).The flesh with seed ext...
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2007
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my-uitm-ir.1000692024-08-26T05:05:17Z Effects of hylocereus polyrhizus flesh on blood parameters in mice / Nur Mardhiya Darnalis 2007 Darnalis, Nur Mardhiya Examination of the blood RM Therapeutics. Pharmacology RS Pharmacy and materia medica This study was conducted to determine the potential effects and toxicity associated with the use of Hylocereus Polyrhizus on blood parameters in mice. Two groups of six mice were given either the flesh with seed extract of HP (treatment group) or normal saline (control group).The flesh with seed extract of Hylocereus polyrhizus was administered by gavage with the use of oral needle. Blood samples were obtained by cardiac puncture. No mortality and clinical signs of toxicity were observed upon administration of HP for both acute and sub acute toxicity studies. Blood analysis showed significant changes in certain blood parameters. In the acute toxicity study, the blood levels of urea were significantly lower in the treatment group. In the sub acute toxicity study, there were no significance differences between both groups for all parameters. It can be concluded that the flesh's extract of HP can affect certain blood parameters and possibly has hepatoprotective effects. Further studies are needed to validate these effects in order to ensure the safe consumption of HP fruit. 2007 Thesis https://ir.uitm.edu.my/id/eprint/100069/ https://ir.uitm.edu.my/id/eprint/100069/1/100069.PDF text en public degree Universiti Teknologi MARA (Kampus Puncak Alam) Faculty of Pharmacy Sulong, Adnan |
| institution |
Universiti Teknologi MARA |
| collection |
UiTM Institutional Repository |
| language |
English |
| advisor |
Sulong, Adnan |
| topic |
Examination of the blood Examination of the blood RS Pharmacy and materia medica |
| spellingShingle |
Examination of the blood Examination of the blood RS Pharmacy and materia medica Darnalis, Nur Mardhiya Effects of hylocereus polyrhizus flesh on blood parameters in mice / Nur Mardhiya Darnalis |
| description |
This study was conducted to determine the potential effects and toxicity associated with the use of Hylocereus Polyrhizus on blood parameters in mice. Two groups of six mice were given either the flesh with seed extract of HP (treatment group) or normal saline (control group).The flesh with seed extract of Hylocereus polyrhizus was administered by gavage with the use of oral needle. Blood samples were obtained by cardiac puncture. No mortality and clinical signs of toxicity were observed upon administration of HP for both acute and sub acute toxicity studies. Blood analysis showed significant changes in certain blood parameters. In the acute toxicity study, the blood levels of urea were significantly lower in the treatment group. In the sub acute toxicity study, there were no significance differences between both groups for all parameters. It can be concluded that the flesh's extract of HP can affect certain blood parameters and possibly has hepatoprotective effects. Further studies are needed to validate these effects in order to ensure the safe consumption of HP fruit. |
| format |
Thesis |
| qualification_level |
Bachelor degree |
| author |
Darnalis, Nur Mardhiya |
| author_facet |
Darnalis, Nur Mardhiya |
| author_sort |
Darnalis, Nur Mardhiya |
| title |
Effects of hylocereus polyrhizus flesh on blood parameters in mice / Nur Mardhiya Darnalis |
| title_short |
Effects of hylocereus polyrhizus flesh on blood parameters in mice / Nur Mardhiya Darnalis |
| title_full |
Effects of hylocereus polyrhizus flesh on blood parameters in mice / Nur Mardhiya Darnalis |
| title_fullStr |
Effects of hylocereus polyrhizus flesh on blood parameters in mice / Nur Mardhiya Darnalis |
| title_full_unstemmed |
Effects of hylocereus polyrhizus flesh on blood parameters in mice / Nur Mardhiya Darnalis |
| title_sort |
effects of hylocereus polyrhizus flesh on blood parameters in mice / nur mardhiya darnalis |
| granting_institution |
Universiti Teknologi MARA (Kampus Puncak Alam) |
| granting_department |
Faculty of Pharmacy |
| publishDate |
2007 |
| url |
https://ir.uitm.edu.my/id/eprint/100069/1/100069.PDF |
| _version_ |
1811769056377700352 |