Dissolution of calcium ions from alginate matrix / Nur Hazirah Kamarudin

The profiles of calcium ion leaching from alginate beads in relation to the property of dissolution medium modified by microwave were investigated. The beads were prepared by extrusion method with sulphanilamide, sulphathiazole and sulphamerazine as model drugs. The dissolution medium was subjected...

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Main Author:	Kamarudin, Nur Hazirah
Format:	Thesis
Language:	English
Published:	2008
Subjects:	Pharmaceutical chemistry
Online Access:	https://ir.uitm.edu.my/id/eprint/101152/1/101152.PDF
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id	my-uitm-ir.101152
record_format	uketd_dc
spelling	my-uitm-ir.1011522024-09-28T23:32:26Z Dissolution of calcium ions from alginate matrix / Nur Hazirah Kamarudin 2008 Kamarudin, Nur Hazirah Pharmaceutical chemistry The profiles of calcium ion leaching from alginate beads in relation to the property of dissolution medium modified by microwave were investigated. The beads were prepared by extrusion method with sulphanilamide, sulphathiazole and sulphamerazine as model drugs. The dissolution medium was subjected to microwave treatment at 80 W and 300 W. The profile of calcium release was determined by dissolution testing and atomic absorption spectrophotometry techniques. Untreated water possessed more dissolved carbon dioxide and thus led to the formation of carbonic acid. The protons from acid replaced calcium ions and increased the percentage of calcium release when relatively alginate sulphanilamide beads were concerned. The water treated by microwave at 300 W had sufficient kinetic energy to penetrate into the alginate beads. The kinetic energy of water enabled the polymer to loosen their matrix crosslinkages through dissociation of calcium ions from alginates beads. A more hydrophobic alginate-sulphathiazole bead required such water to induce calcium leaching. Lastly, in the case of alginate sulphamerazine beads there was no apparent effect of dissolution medium treated by microwave on their calcium leaching profile. 2008 Thesis https://ir.uitm.edu.my/id/eprint/101152/ https://ir.uitm.edu.my/id/eprint/101152/1/101152.PDF text en public degree Universiti Teknologi MARA (Kampus Puncak Alam) Faculty of Pharmacy Wui, Wong Tin
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
advisor	Wui, Wong Tin
topic	Pharmaceutical chemistry
spellingShingle	Pharmaceutical chemistry Kamarudin, Nur Hazirah Dissolution of calcium ions from alginate matrix / Nur Hazirah Kamarudin
description	The profiles of calcium ion leaching from alginate beads in relation to the property of dissolution medium modified by microwave were investigated. The beads were prepared by extrusion method with sulphanilamide, sulphathiazole and sulphamerazine as model drugs. The dissolution medium was subjected to microwave treatment at 80 W and 300 W. The profile of calcium release was determined by dissolution testing and atomic absorption spectrophotometry techniques. Untreated water possessed more dissolved carbon dioxide and thus led to the formation of carbonic acid. The protons from acid replaced calcium ions and increased the percentage of calcium release when relatively alginate sulphanilamide beads were concerned. The water treated by microwave at 300 W had sufficient kinetic energy to penetrate into the alginate beads. The kinetic energy of water enabled the polymer to loosen their matrix crosslinkages through dissociation of calcium ions from alginates beads. A more hydrophobic alginate-sulphathiazole bead required such water to induce calcium leaching. Lastly, in the case of alginate sulphamerazine beads there was no apparent effect of dissolution medium treated by microwave on their calcium leaching profile.
format	Thesis
qualification_level	Bachelor degree
author	Kamarudin, Nur Hazirah
author_facet	Kamarudin, Nur Hazirah
author_sort	Kamarudin, Nur Hazirah
title	Dissolution of calcium ions from alginate matrix / Nur Hazirah Kamarudin
title_short	Dissolution of calcium ions from alginate matrix / Nur Hazirah Kamarudin
title_full	Dissolution of calcium ions from alginate matrix / Nur Hazirah Kamarudin
title_fullStr	Dissolution of calcium ions from alginate matrix / Nur Hazirah Kamarudin
title_full_unstemmed	Dissolution of calcium ions from alginate matrix / Nur Hazirah Kamarudin
title_sort	dissolution of calcium ions from alginate matrix / nur hazirah kamarudin
granting_institution	Universiti Teknologi MARA (Kampus Puncak Alam)
granting_department	Faculty of Pharmacy
publishDate	2008
url	https://ir.uitm.edu.my/id/eprint/101152/1/101152.PDF
_version_	1811769135526313984

Dissolution of calcium ions from alginate matrix / Nur Hazirah Kamarudin

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