The effects of dioscorea hispida supplementation in oxidative damage-induced toxicity on placental tissues of maternal rats / Muhamad Faizul Adhzim Yusery

The effects of dioscorea hispida supplementation in oxidative damage-induced toxicity on placental tissues of maternal rats / Muhamad Faizul Adhzim Yusery

Dioscorea hispida (D. hispida) has been considered as staple foods in tropical and subtropical regions. However, it high contents of disocorine and cyanides has limited it to be utilized as nutrient sources. Toxic compounds of D. hispida may lead to overproduction of free radicals and cause oxidativ...

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Main Author: Yusery, Muhamad Faizul Adhzim
Format: Thesis
Language:English
Published: 2016
Online Access:https://ir.uitm.edu.my/id/eprint/101210/1/101210.pdf
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spelling my-uitm-ir.1012102024-08-27T17:21:37Z The effects of dioscorea hispida supplementation in oxidative damage-induced toxicity on placental tissues of maternal rats / Muhamad Faizul Adhzim Yusery 2016 Yusery, Muhamad Faizul Adhzim Dioscorea hispida (D. hispida) has been considered as staple foods in tropical and subtropical regions. However, it high contents of disocorine and cyanides has limited it to be utilized as nutrient sources. Toxic compounds of D. hispida may lead to overproduction of free radicals and cause oxidative damage. In pregnancy, imbalance level of ROS may lead to miscarriage. The present study was performed to investigate the effects of D. hispida on the placental tissues of maternal rats for 15 days through oxidative damage and lipid peroxidation. Pregnant Sprague Dawley rats were divided into 4 different treatment groups (n=5) which consists of a negative control group and 3 groups supplemented with aqueous extract of D. hispida at different concentrations (250 mg/kg, 500 mg/kg, and 1000 mg/kg body weight). Extract of D. hispida were administered daily on day 6 to day 20 of pregnancy. The rats were euthanized at day 21 and the placenta tissues were harvested for total superoxide dismutase (SOD) inhibition activity and lipid peroxidation (malondialdehyde/MDA) determination. No statistical significant difference showed between all groups on SOD inhibition activities (p>0.05). However, there was increasing pattern on 250 mg/kg and 500 mg/kg group compared to control group with decreasing pattern at 1000 mg/kg group compared to 500 mg/kg group. The MDA level determination showed an increasing trend in all experimental groups compared to control group. Significantly differences were observed in control group compared to 1000 mg/kg group and for 250 mg/kg group compared to 1000 mg/kg group (p<0.05). Overall results of the current finding suggested that supplementation of D. hispida on the placenta tissues of maternal rats for 15 days may give damaging effects through oxidative damage and lipid peroxidation. 2016 Thesis https://ir.uitm.edu.my/id/eprint/101210/ https://ir.uitm.edu.my/id/eprint/101210/1/101210.pdf text en public degree Universiti Teknologi MARA (UiTM) Faculty of Health Sciences
institution Universiti Teknologi MARA
collection UiTM Institutional Repository
language English
description Dioscorea hispida (D. hispida) has been considered as staple foods in tropical and subtropical regions. However, it high contents of disocorine and cyanides has limited it to be utilized as nutrient sources. Toxic compounds of D. hispida may lead to overproduction of free radicals and cause oxidative damage. In pregnancy, imbalance level of ROS may lead to miscarriage. The present study was performed to investigate the effects of D. hispida on the placental tissues of maternal rats for 15 days through oxidative damage and lipid peroxidation. Pregnant Sprague Dawley rats were divided into 4 different treatment groups (n=5) which consists of a negative control group and 3 groups supplemented with aqueous extract of D. hispida at different concentrations (250 mg/kg, 500 mg/kg, and 1000 mg/kg body weight). Extract of D. hispida were administered daily on day 6 to day 20 of pregnancy. The rats were euthanized at day 21 and the placenta tissues were harvested for total superoxide dismutase (SOD) inhibition activity and lipid peroxidation (malondialdehyde/MDA) determination. No statistical significant difference showed between all groups on SOD inhibition activities (p>0.05). However, there was increasing pattern on 250 mg/kg and 500 mg/kg group compared to control group with decreasing pattern at 1000 mg/kg group compared to 500 mg/kg group. The MDA level determination showed an increasing trend in all experimental groups compared to control group. Significantly differences were observed in control group compared to 1000 mg/kg group and for 250 mg/kg group compared to 1000 mg/kg group (p<0.05). Overall results of the current finding suggested that supplementation of D. hispida on the placenta tissues of maternal rats for 15 days may give damaging effects through oxidative damage and lipid peroxidation.
format Thesis
qualification_level Bachelor degree
author Yusery, Muhamad Faizul Adhzim
spellingShingle Yusery, Muhamad Faizul Adhzim
The effects of dioscorea hispida supplementation in oxidative damage-induced toxicity on placental tissues of maternal rats / Muhamad Faizul Adhzim Yusery
author_facet Yusery, Muhamad Faizul Adhzim
author_sort Yusery, Muhamad Faizul Adhzim
title The effects of dioscorea hispida supplementation in oxidative damage-induced toxicity on placental tissues of maternal rats / Muhamad Faizul Adhzim Yusery
title_short The effects of dioscorea hispida supplementation in oxidative damage-induced toxicity on placental tissues of maternal rats / Muhamad Faizul Adhzim Yusery
title_full The effects of dioscorea hispida supplementation in oxidative damage-induced toxicity on placental tissues of maternal rats / Muhamad Faizul Adhzim Yusery
title_fullStr The effects of dioscorea hispida supplementation in oxidative damage-induced toxicity on placental tissues of maternal rats / Muhamad Faizul Adhzim Yusery
title_full_unstemmed The effects of dioscorea hispida supplementation in oxidative damage-induced toxicity on placental tissues of maternal rats / Muhamad Faizul Adhzim Yusery
title_sort effects of dioscorea hispida supplementation in oxidative damage-induced toxicity on placental tissues of maternal rats / muhamad faizul adhzim yusery
granting_institution Universiti Teknologi MARA (UiTM)
granting_department Faculty of Health Sciences
publishDate 2016
url https://ir.uitm.edu.my/id/eprint/101210/1/101210.pdf
_version_ 1811769146280509440

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