Effect of gynura procumbens aqueous extraction on interleukin-2 production in peripheral blood mononuclear cells / Nadirah Anis Che Abdullah

Immunomodulation is a process which can modify the immune system of an organism by intruding with its function. Medicinal herbs and their bioactive component had indicated to be a crucial source of immunomodulators. Research has proven that the herbal preparation from plant can be safer and effectiv...

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Main Author:	Che Abdullah, Nadirah Anis
Format:	Thesis
Language:	English
Published:	2016
Online Access:	https://ir.uitm.edu.my/id/eprint/101217/1/101217.pdf
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id	my-uitm-ir.101217
record_format	uketd_dc
spelling	my-uitm-ir.1012172024-08-27T17:12:38Z Effect of gynura procumbens aqueous extraction on interleukin-2 production in peripheral blood mononuclear cells / Nadirah Anis Che Abdullah 2016 Che Abdullah, Nadirah Anis Immunomodulation is a process which can modify the immune system of an organism by intruding with its function. Medicinal herbs and their bioactive component had indicated to be a crucial source of immunomodulators. Research has proven that the herbal preparation from plant can be safer and effective rather than conventional medicines. Objective: In this study, we want to determine the effect of Gynura procumbens aqueous extraction on Interleukin-2 expression in Peripheral Blood Mononuclear Cells. Method: Three different doses (50, 200 and 800 μg/ml) of Gynura procumbens are cultured on PBMCs with or without inhibitors (CLI-095 and Polymyxin B sulfate) to determine the expression of the IL-2 using Luminex assay. Result: Result indicated Gynura procumbens aqueous extraction has immunomodulatory effect. Data was analyzed using one-way analysis of variance (ANOVA) to compare between control group and treated groups of different doses of Gynura procumbens were not significantly different (P >0.005), as well as co-treatment with inhibitors which analyzed using Independent sample t-test also shows not significantly different (P >0.005). Conclusion: Gynura procumbens aqueous extract has an immunomodulatory effect in PBMCs on expression of IL-2. 2016 Thesis https://ir.uitm.edu.my/id/eprint/101217/ https://ir.uitm.edu.my/id/eprint/101217/1/101217.pdf text en public degree Universiti Teknologi MARA (UiTM) Faculty of Health Sciences
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
description	Immunomodulation is a process which can modify the immune system of an organism by intruding with its function. Medicinal herbs and their bioactive component had indicated to be a crucial source of immunomodulators. Research has proven that the herbal preparation from plant can be safer and effective rather than conventional medicines. Objective: In this study, we want to determine the effect of Gynura procumbens aqueous extraction on Interleukin-2 expression in Peripheral Blood Mononuclear Cells. Method: Three different doses (50, 200 and 800 μg/ml) of Gynura procumbens are cultured on PBMCs with or without inhibitors (CLI-095 and Polymyxin B sulfate) to determine the expression of the IL-2 using Luminex assay. Result: Result indicated Gynura procumbens aqueous extraction has immunomodulatory effect. Data was analyzed using one-way analysis of variance (ANOVA) to compare between control group and treated groups of different doses of Gynura procumbens were not significantly different (P >0.005), as well as co-treatment with inhibitors which analyzed using Independent sample t-test also shows not significantly different (P >0.005). Conclusion: Gynura procumbens aqueous extract has an immunomodulatory effect in PBMCs on expression of IL-2.
format	Thesis
qualification_level	Bachelor degree
author	Che Abdullah, Nadirah Anis
spellingShingle	Che Abdullah, Nadirah Anis Effect of gynura procumbens aqueous extraction on interleukin-2 production in peripheral blood mononuclear cells / Nadirah Anis Che Abdullah
author_facet	Che Abdullah, Nadirah Anis
author_sort	Che Abdullah, Nadirah Anis
title	Effect of gynura procumbens aqueous extraction on interleukin-2 production in peripheral blood mononuclear cells / Nadirah Anis Che Abdullah
title_short	Effect of gynura procumbens aqueous extraction on interleukin-2 production in peripheral blood mononuclear cells / Nadirah Anis Che Abdullah
title_full	Effect of gynura procumbens aqueous extraction on interleukin-2 production in peripheral blood mononuclear cells / Nadirah Anis Che Abdullah
title_fullStr	Effect of gynura procumbens aqueous extraction on interleukin-2 production in peripheral blood mononuclear cells / Nadirah Anis Che Abdullah
title_full_unstemmed	Effect of gynura procumbens aqueous extraction on interleukin-2 production in peripheral blood mononuclear cells / Nadirah Anis Che Abdullah
title_sort	effect of gynura procumbens aqueous extraction on interleukin-2 production in peripheral blood mononuclear cells / nadirah anis che abdullah
granting_institution	Universiti Teknologi MARA (UiTM)
granting_department	Faculty of Health Sciences
publishDate	2016
url	https://ir.uitm.edu.my/id/eprint/101217/1/101217.pdf
_version_	1811769147859664896

Effect of gynura procumbens aqueous extraction on interleukin-2 production in peripheral blood mononuclear cells / Nadirah Anis Che Abdullah

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