Synthesis of two substituted cyclohexenone via Michael Addition and intramolecular aldol condensation (Robinson Annulation) with ethyl acetoacetate / Muhamad Nor Syafik Yahya

This project was to synthesize two different Robinson products from two different chalcones derivatives. The precursor for Robinson Product 1 is 4-chloro-4’- methoxychalcone and ethyl acetoacetate while the precursor for Robinson Product 2 is 3-nitrochalcone. Preparation of chalcone derivatives invo...

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Main Author:	Yahya, Muhamad Nor Syafik
Format:	Thesis
Language:	English
Published:	2009
Online Access:	https://ir.uitm.edu.my/id/eprint/101219/1/101219.pdf
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id	my-uitm-ir.101219
record_format	uketd_dc
spelling	my-uitm-ir.1012192024-09-12T04:54:41Z Synthesis of two substituted cyclohexenone via Michael Addition and intramolecular aldol condensation (Robinson Annulation) with ethyl acetoacetate / Muhamad Nor Syafik Yahya 2009 Yahya, Muhamad Nor Syafik This project was to synthesize two different Robinson products from two different chalcones derivatives. The precursor for Robinson Product 1 is 4-chloro-4’- methoxychalcone and ethyl acetoacetate while the precursor for Robinson Product 2 is 3-nitrochalcone. Preparation of chalcone derivatives involves Aldol Condensation reaction which required basic medium to initiate the reaction. On the other hand, preparation of Robinson product involved reaction of Michael Addition reaction and Intramolecular Aldol Condensation (Robinson Annulation) reaction which also required basic medium to act as the catalyst which responsible to initiate the reaction. In this experiment, we use sodium hydroxide as the catalyst. Upon completion of this project, we have successfully obtained a good yield of both products. This evidence was supported through infrared, H NMR and C NMR spectroscopy analysis. 2009 Thesis https://ir.uitm.edu.my/id/eprint/101219/ https://ir.uitm.edu.my/id/eprint/101219/1/101219.pdf text en public degree Universiti Teknologi MARA (UiTM) Faculty of Applied Sciences Zakaria, Yazan
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
advisor	Zakaria, Yazan
description	This project was to synthesize two different Robinson products from two different chalcones derivatives. The precursor for Robinson Product 1 is 4-chloro-4’- methoxychalcone and ethyl acetoacetate while the precursor for Robinson Product 2 is 3-nitrochalcone. Preparation of chalcone derivatives involves Aldol Condensation reaction which required basic medium to initiate the reaction. On the other hand, preparation of Robinson product involved reaction of Michael Addition reaction and Intramolecular Aldol Condensation (Robinson Annulation) reaction which also required basic medium to act as the catalyst which responsible to initiate the reaction. In this experiment, we use sodium hydroxide as the catalyst. Upon completion of this project, we have successfully obtained a good yield of both products. This evidence was supported through infrared, H NMR and C NMR spectroscopy analysis.
format	Thesis
qualification_level	Bachelor degree
author	Yahya, Muhamad Nor Syafik
spellingShingle	Yahya, Muhamad Nor Syafik Synthesis of two substituted cyclohexenone via Michael Addition and intramolecular aldol condensation (Robinson Annulation) with ethyl acetoacetate / Muhamad Nor Syafik Yahya
author_facet	Yahya, Muhamad Nor Syafik
author_sort	Yahya, Muhamad Nor Syafik
title	Synthesis of two substituted cyclohexenone via Michael Addition and intramolecular aldol condensation (Robinson Annulation) with ethyl acetoacetate / Muhamad Nor Syafik Yahya
title_short	Synthesis of two substituted cyclohexenone via Michael Addition and intramolecular aldol condensation (Robinson Annulation) with ethyl acetoacetate / Muhamad Nor Syafik Yahya
title_full	Synthesis of two substituted cyclohexenone via Michael Addition and intramolecular aldol condensation (Robinson Annulation) with ethyl acetoacetate / Muhamad Nor Syafik Yahya
title_fullStr	Synthesis of two substituted cyclohexenone via Michael Addition and intramolecular aldol condensation (Robinson Annulation) with ethyl acetoacetate / Muhamad Nor Syafik Yahya
title_full_unstemmed	Synthesis of two substituted cyclohexenone via Michael Addition and intramolecular aldol condensation (Robinson Annulation) with ethyl acetoacetate / Muhamad Nor Syafik Yahya
title_sort	synthesis of two substituted cyclohexenone via michael addition and intramolecular aldol condensation (robinson annulation) with ethyl acetoacetate / muhamad nor syafik yahya
granting_institution	Universiti Teknologi MARA (UiTM)
granting_department	Faculty of Applied Sciences
publishDate	2009
url	https://ir.uitm.edu.my/id/eprint/101219/1/101219.pdf
_version_	1811769148385001472

Synthesis of two substituted cyclohexenone via Michael Addition and intramolecular aldol condensation (Robinson Annulation) with ethyl acetoacetate / Muhamad Nor Syafik Yahya

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