Dose-response effects on spatial learning and memory after subacute exposure of HAB10R12 endophytic extract in mice / Radhia Azia Redzuan

An endophyte is an endosymbiont, often a bacterium or fungus, which lives within a plant for at least part of its life without causing apparent disease. Endophytes may benefit host plants by preventing pathogenic organisms from colonizing them. Our strain of interest is HAB10R12 , which is found in...

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Main Author:	Redzuan, Radhia Azia
Format:	Thesis
Language:	English
Published:	2008
Subjects:	Pharmaceutical dosage forms
Online Access:	https://ir.uitm.edu.my/id/eprint/101224/1/101224.PDF
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id	my-uitm-ir.101224
record_format	uketd_dc
spelling	my-uitm-ir.1012242024-09-28T23:35:28Z Dose-response effects on spatial learning and memory after subacute exposure of HAB10R12 endophytic extract in mice / Radhia Azia Redzuan 2008 Redzuan, Radhia Azia Pharmaceutical dosage forms An endophyte is an endosymbiont, often a bacterium or fungus, which lives within a plant for at least part of its life without causing apparent disease. Endophytes may benefit host plants by preventing pathogenic organisms from colonizing them. Our strain of interest is HAB10R12 , which is found in local forest. Preliminary studies have shown that extract from this strain might have some neuroprotective properties. This study was aimed to investigate the dose-response effects of endophytic extract of HAB10R12 on spatial learning and memory after subacute exposure in mice. For the evaluation of the dose-response effects on spatial learning and memory, the Morris Water Maze (MWM) test is performed. The endophytic extract dose of 5, 10, 20 mg/kg were subacutely administered through the intraperitoneal route to mice (n = 6 per group) everyday for 14 days. Normal saline was administered intraperitoneally as a control and memantine (an NMDA receptor antagonist) as a positive control. The Morris Water Maze test was carried out on day 3, 6, 9, 12, 15 (after 15 minutes of treatment). From the result obtained only memantine showed a significant difference in enhancing the spatial learning and memory compared to the blank control. The 5mg/kg, 10 mg/kg of the HAB10R12 endophytic extract did not show statistically significant difference (P > 0.05) towards the spatial learning and memory. Further studies should be conducted to uncover the possible action of HAB10R12 endophytic extract on the human pathophysiology 2008 Thesis https://ir.uitm.edu.my/id/eprint/101224/ https://ir.uitm.edu.my/id/eprint/101224/1/101224.PDF text en public degree Universiti Teknologi MARA (Kampus Puncak Alam) Faculty of Pharmacy
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
topic	Pharmaceutical dosage forms
spellingShingle	Pharmaceutical dosage forms Redzuan, Radhia Azia Dose-response effects on spatial learning and memory after subacute exposure of HAB10R12 endophytic extract in mice / Radhia Azia Redzuan
description	An endophyte is an endosymbiont, often a bacterium or fungus, which lives within a plant for at least part of its life without causing apparent disease. Endophytes may benefit host plants by preventing pathogenic organisms from colonizing them. Our strain of interest is HAB10R12 , which is found in local forest. Preliminary studies have shown that extract from this strain might have some neuroprotective properties. This study was aimed to investigate the dose-response effects of endophytic extract of HAB10R12 on spatial learning and memory after subacute exposure in mice. For the evaluation of the dose-response effects on spatial learning and memory, the Morris Water Maze (MWM) test is performed. The endophytic extract dose of 5, 10, 20 mg/kg were subacutely administered through the intraperitoneal route to mice (n = 6 per group) everyday for 14 days. Normal saline was administered intraperitoneally as a control and memantine (an NMDA receptor antagonist) as a positive control. The Morris Water Maze test was carried out on day 3, 6, 9, 12, 15 (after 15 minutes of treatment). From the result obtained only memantine showed a significant difference in enhancing the spatial learning and memory compared to the blank control. The 5mg/kg, 10 mg/kg of the HAB10R12 endophytic extract did not show statistically significant difference (P > 0.05) towards the spatial learning and memory. Further studies should be conducted to uncover the possible action of HAB10R12 endophytic extract on the human pathophysiology
format	Thesis
qualification_level	Bachelor degree
author	Redzuan, Radhia Azia
author_facet	Redzuan, Radhia Azia
author_sort	Redzuan, Radhia Azia
title	Dose-response effects on spatial learning and memory after subacute exposure of HAB10R12 endophytic extract in mice / Radhia Azia Redzuan
title_short	Dose-response effects on spatial learning and memory after subacute exposure of HAB10R12 endophytic extract in mice / Radhia Azia Redzuan
title_full	Dose-response effects on spatial learning and memory after subacute exposure of HAB10R12 endophytic extract in mice / Radhia Azia Redzuan
title_fullStr	Dose-response effects on spatial learning and memory after subacute exposure of HAB10R12 endophytic extract in mice / Radhia Azia Redzuan
title_full_unstemmed	Dose-response effects on spatial learning and memory after subacute exposure of HAB10R12 endophytic extract in mice / Radhia Azia Redzuan
title_sort	dose-response effects on spatial learning and memory after subacute exposure of hab10r12 endophytic extract in mice / radhia azia redzuan
granting_institution	Universiti Teknologi MARA (Kampus Puncak Alam)
granting_department	Faculty of Pharmacy
publishDate	2008
url	https://ir.uitm.edu.my/id/eprint/101224/1/101224.PDF
_version_	1811769149412605952

Dose-response effects on spatial learning and memory after subacute exposure of HAB10R12 endophytic extract in mice / Radhia Azia Redzuan

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