The effect of preparation variables on the poly (D,L-lactide-co-glycolide) (PLGA) microparticles by modified emulsification diffusion method / Asmirah Md Redzuan

Poly (D,L-lactide-co-glycolide) (PLGA) is the most commonly used biodegradable polymer in microparticles and nanoparticles. The PLGA microparticles were commonly prepared by technique of evaporation but less with diffusion method. The aim of this study was to prepare and determine the effect of prep...

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Main Author:	Md Redzuan, Asmirah
Format:	Thesis
Language:	English
Published:	2008
Subjects:	Pharmacopoeias Pharmaceutical chemistry
Online Access:	https://ir.uitm.edu.my/id/eprint/101227/1/101227.PDF
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spelling	my-uitm-ir.1012272024-09-28T23:32:55Z The effect of preparation variables on the poly (D,L-lactide-co-glycolide) (PLGA) microparticles by modified emulsification diffusion method / Asmirah Md Redzuan 2008 Md Redzuan, Asmirah Pharmacopoeias Pharmaceutical chemistry Poly (D,L-lactide-co-glycolide) (PLGA) is the most commonly used biodegradable polymer in microparticles and nanoparticles. The PLGA microparticles were commonly prepared by technique of evaporation but less with diffusion method. The aim of this study was to prepare and determine the effect of preparation variables on PLGA microparticles by the modified emulsification diffusion method. The preparation method consists of emulsifying a solution of polymer and an aqueous phase containing stabilizer, previously saturated, followed by adding excess water. The concept of this method used a binary mixture, dichloromethane (DCM) and acetone (ACE) as polymer solvents and using of PY A as stabilizer. Influence of process variables such two particular variables that are PY A concentration (0.1 %, 0.5%, 1.0%, 2.0% and 3.0% w/v) and homogenizer speed (1000, 3000, 5000, 7000 and 9000 rpm) were studied. The discrete powder of PLGA microparticles was obtained by freeze drying. The mean particle size, particle size distribution and the morphology of the PLGA microparticles were evaluated. The results were clarified that both parameters, PY A concentration and homogenizer speed had influenced on the mean particle size and particle distribution of PLGA microparticles. As the PY A concentration and/or homogenizer speed increase, the mean particle sizes of PLGA microparticles were decreased. The prepared PLGA microparticles with different homogenizer speed were in unimodally dispersed particles with mean particle size of about range from 7 µm to 45 µm, whereas those prepared with different PY A concentration exhibited bimodal distribution with mean particle size of about range from 9 µm to 52 µm. The micrograph from scanning electron (SEM) revealed the surface of PLGA microparticles was not smooth and the particle size distribution was not good. 2008 Thesis https://ir.uitm.edu.my/id/eprint/101227/ https://ir.uitm.edu.my/id/eprint/101227/1/101227.PDF text en public degree Universiti Teknologi MARA (Kampus Puncak Alam) Faculty of Pharmacy Sameni, Javad
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
advisor	Sameni, Javad
topic	Pharmacopoeias Pharmaceutical chemistry
spellingShingle	Pharmacopoeias Pharmaceutical chemistry Md Redzuan, Asmirah The effect of preparation variables on the poly (D,L-lactide-co-glycolide) (PLGA) microparticles by modified emulsification diffusion method / Asmirah Md Redzuan
description	Poly (D,L-lactide-co-glycolide) (PLGA) is the most commonly used biodegradable polymer in microparticles and nanoparticles. The PLGA microparticles were commonly prepared by technique of evaporation but less with diffusion method. The aim of this study was to prepare and determine the effect of preparation variables on PLGA microparticles by the modified emulsification diffusion method. The preparation method consists of emulsifying a solution of polymer and an aqueous phase containing stabilizer, previously saturated, followed by adding excess water. The concept of this method used a binary mixture, dichloromethane (DCM) and acetone (ACE) as polymer solvents and using of PY A as stabilizer. Influence of process variables such two particular variables that are PY A concentration (0.1 %, 0.5%, 1.0%, 2.0% and 3.0% w/v) and homogenizer speed (1000, 3000, 5000, 7000 and 9000 rpm) were studied. The discrete powder of PLGA microparticles was obtained by freeze drying. The mean particle size, particle size distribution and the morphology of the PLGA microparticles were evaluated. The results were clarified that both parameters, PY A concentration and homogenizer speed had influenced on the mean particle size and particle distribution of PLGA microparticles. As the PY A concentration and/or homogenizer speed increase, the mean particle sizes of PLGA microparticles were decreased. The prepared PLGA microparticles with different homogenizer speed were in unimodally dispersed particles with mean particle size of about range from 7 µm to 45 µm, whereas those prepared with different PY A concentration exhibited bimodal distribution with mean particle size of about range from 9 µm to 52 µm. The micrograph from scanning electron (SEM) revealed the surface of PLGA microparticles was not smooth and the particle size distribution was not good.
format	Thesis
qualification_level	Bachelor degree
author	Md Redzuan, Asmirah
author_facet	Md Redzuan, Asmirah
author_sort	Md Redzuan, Asmirah
title	The effect of preparation variables on the poly (D,L-lactide-co-glycolide) (PLGA) microparticles by modified emulsification diffusion method / Asmirah Md Redzuan
title_short	The effect of preparation variables on the poly (D,L-lactide-co-glycolide) (PLGA) microparticles by modified emulsification diffusion method / Asmirah Md Redzuan
title_full	The effect of preparation variables on the poly (D,L-lactide-co-glycolide) (PLGA) microparticles by modified emulsification diffusion method / Asmirah Md Redzuan
title_fullStr	The effect of preparation variables on the poly (D,L-lactide-co-glycolide) (PLGA) microparticles by modified emulsification diffusion method / Asmirah Md Redzuan
title_full_unstemmed	The effect of preparation variables on the poly (D,L-lactide-co-glycolide) (PLGA) microparticles by modified emulsification diffusion method / Asmirah Md Redzuan
title_sort	effect of preparation variables on the poly (d,l-lactide-co-glycolide) (plga) microparticles by modified emulsification diffusion method / asmirah md redzuan
granting_institution	Universiti Teknologi MARA (Kampus Puncak Alam)
granting_department	Faculty of Pharmacy
publishDate	2008
url	https://ir.uitm.edu.my/id/eprint/101227/1/101227.PDF
_version_	1811769149915922432

The effect of preparation variables on the poly (D,L-lactide-co-glycolide) (PLGA) microparticles by modified emulsification diffusion method / Asmirah Md Redzuan

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