Development and evaluation of waglinol oil nanoemulsion using high pressure homogenizer / Mariam Rushdan
Nanoemulsion is a type of emulsion. It consist of fine oil-in-water dispersions, with the droplets covering the size range of 20-200nm. It can be achieved through emulsification process. One of the processes is through high-pressure homogenizer (HPH). The mechanical effect of HPH governs nanoemulsio...
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my-uitm-ir.1012292024-09-28T23:38:04Z Development and evaluation of waglinol oil nanoemulsion using high pressure homogenizer / Mariam Rushdan 2008 Rushdan, Mariam Pharmaceutical technology Pharmaceutical supplies Nanoemulsion is a type of emulsion. It consist of fine oil-in-water dispersions, with the droplets covering the size range of 20-200nm. It can be achieved through emulsification process. One of the processes is through high-pressure homogenizer (HPH). The mechanical effect of HPH governs nanoemulsion properties such as stability, partical size and uniformity. Consequently, the specific mechanical effects during emulsification are the interest when well-defined nanoemulsion properties are needed. Therefore, in this work, nanoemulsion study consisting of water, waglinol oil and a mixture of nonionic surfactants using HPH was performed. The optimum formulation was developed by direct emulsification which consists of waglinol oil, tween 80, span 80 and distilled water (2: 0.8: 0.2: 7). Waglinol oil pre-emulsion were homogenized at various pressures ranging from 40 MPa to 80 MPa using a lab scale HPH. Different cycles were applied ranging from O to 15 cycles. The influence of homogenizing pressure on the size, stability and zeta potential were determined. The size of the nanoemulsion does not differ relatively as the pressure and cycle of the HPH increase. The zeta potential of nanoemulsions are negative. Furthermore, different pressure and cycle of HPH produces different stability rate. 2008 Thesis https://ir.uitm.edu.my/id/eprint/101229/ https://ir.uitm.edu.my/id/eprint/101229/1/101229.PDF text en public degree Universiti Teknologi MARA (Kampus Puncak Alam) Faculty of Pharmacy Eid, Ahmad Mustafa |
| institution |
Universiti Teknologi MARA |
| collection |
UiTM Institutional Repository |
| language |
English |
| advisor |
Eid, Ahmad Mustafa |
| topic |
Pharmaceutical technology Pharmaceutical supplies |
| spellingShingle |
Pharmaceutical technology Pharmaceutical supplies Rushdan, Mariam Development and evaluation of waglinol oil nanoemulsion using high pressure homogenizer / Mariam Rushdan |
| description |
Nanoemulsion is a type of emulsion. It consist of fine oil-in-water dispersions, with the droplets covering the size range of 20-200nm. It can be achieved through emulsification process. One of the processes is through high-pressure homogenizer (HPH). The mechanical effect of HPH governs nanoemulsion properties such as stability, partical size and uniformity. Consequently, the specific mechanical effects during emulsification are the interest when well-defined nanoemulsion properties are needed. Therefore, in this work, nanoemulsion study consisting of water, waglinol oil and a mixture of nonionic surfactants using HPH was performed. The optimum formulation was developed by direct emulsification which consists of waglinol oil, tween 80, span 80 and distilled water (2: 0.8: 0.2: 7). Waglinol oil pre-emulsion were homogenized at various pressures ranging from 40 MPa to 80 MPa using a lab scale HPH. Different cycles were applied ranging from O to 15 cycles. The influence of homogenizing pressure on the size, stability and zeta potential were determined. The size of the nanoemulsion does not differ relatively as the pressure and cycle of the HPH increase. The zeta potential of nanoemulsions are negative. Furthermore, different pressure and cycle of HPH produces different stability rate. |
| format |
Thesis |
| qualification_level |
Bachelor degree |
| author |
Rushdan, Mariam |
| author_facet |
Rushdan, Mariam |
| author_sort |
Rushdan, Mariam |
| title |
Development and evaluation of waglinol oil nanoemulsion using high pressure homogenizer / Mariam Rushdan |
| title_short |
Development and evaluation of waglinol oil nanoemulsion using high pressure homogenizer / Mariam Rushdan |
| title_full |
Development and evaluation of waglinol oil nanoemulsion using high pressure homogenizer / Mariam Rushdan |
| title_fullStr |
Development and evaluation of waglinol oil nanoemulsion using high pressure homogenizer / Mariam Rushdan |
| title_full_unstemmed |
Development and evaluation of waglinol oil nanoemulsion using high pressure homogenizer / Mariam Rushdan |
| title_sort |
development and evaluation of waglinol oil nanoemulsion using high pressure homogenizer / mariam rushdan |
| granting_institution |
Universiti Teknologi MARA (Kampus Puncak Alam) |
| granting_department |
Faculty of Pharmacy |
| publishDate |
2008 |
| url |
https://ir.uitm.edu.my/id/eprint/101229/1/101229.PDF |
| _version_ |
1811769150427627520 |