Microscopic characterisation of spheroids / Zawiah Ahmad
The influence of microwave treatment on spheroid pore and surface characteristics against drug release profile was investigated. The spheroids were prepared by extrusion spheronization process followed by drying in hot air oven. Both blank and drug loaded spheroids were treated by microwave. The ph...
محفوظ في:
| المؤلف الرئيسي: | |
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| التنسيق: | أطروحة |
| اللغة: | English |
| منشور في: |
2008
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| الموضوعات: | |
| الوصول للمادة أونلاين: | https://ir.uitm.edu.my/id/eprint/101880/1/101880.PDF |
| الوسوم: |
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my-uitm-ir.101880 |
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uketd_dc |
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my-uitm-ir.1018802024-09-28T23:26:54Z Microscopic characterisation of spheroids / Zawiah Ahmad 2008 Ahmad, Zawiah Pharmaceutical dosage forms Pharmaceutical chemistry The influence of microwave treatment on spheroid pore and surface characteristics against drug release profile was investigated. The spheroids were prepared by extrusion spheronization process followed by drying in hot air oven. Both blank and drug loaded spheroids were treated by microwave. The physical changes of spheroids were observed microscopically using a stereo microscope to observe the changes before and after spheroids subjecting to microwave treatment. Drug release profile was determined by performing drug dissolution test for both untreated and treated spheroids. Microwave treatment changed pore and surface characteristics of spheroids. However, an increase in drug dissolution of microwave treated spheroids did not necessary accompany by an increase in pore population of spheroids. Other factors such as drug-polymer interaction, polymer-polymer interaction, polymorphism and crystallinity of drugs, could have roles in drug dissolution. 2008 Thesis https://ir.uitm.edu.my/id/eprint/101880/ https://ir.uitm.edu.my/id/eprint/101880/1/101880.PDF text en public degree Universiti Teknologi MARA (Kampus Puncak Alam) Faculty of Pharmacy Wui, Wong Tin |
| institution |
Universiti Teknologi MARA |
| collection |
UiTM Institutional Repository |
| language |
English |
| advisor |
Wui, Wong Tin |
| topic |
Pharmaceutical dosage forms Pharmaceutical chemistry |
| spellingShingle |
Pharmaceutical dosage forms Pharmaceutical chemistry Ahmad, Zawiah Microscopic characterisation of spheroids / Zawiah Ahmad |
| description |
The influence of microwave treatment on spheroid pore and surface characteristics against drug release profile was investigated. The spheroids were prepared by extrusion spheronization process followed by drying in hot air oven. Both blank and drug loaded spheroids were treated by microwave. The physical changes of spheroids were observed microscopically using a stereo microscope to observe the changes before and after spheroids subjecting to microwave treatment. Drug release profile was determined by performing drug dissolution test for both untreated and treated spheroids. Microwave treatment changed pore and surface characteristics of spheroids. However, an increase in drug dissolution of microwave treated spheroids did not necessary accompany by an increase in pore population of spheroids. Other factors such as drug-polymer interaction, polymer-polymer interaction, polymorphism and crystallinity of drugs, could have roles in drug dissolution. |
| format |
Thesis |
| qualification_level |
Bachelor degree |
| author |
Ahmad, Zawiah |
| author_facet |
Ahmad, Zawiah |
| author_sort |
Ahmad, Zawiah |
| title |
Microscopic characterisation of spheroids / Zawiah Ahmad |
| title_short |
Microscopic characterisation of spheroids / Zawiah Ahmad |
| title_full |
Microscopic characterisation of spheroids / Zawiah Ahmad |
| title_fullStr |
Microscopic characterisation of spheroids / Zawiah Ahmad |
| title_full_unstemmed |
Microscopic characterisation of spheroids / Zawiah Ahmad |
| title_sort |
microscopic characterisation of spheroids / zawiah ahmad |
| granting_institution |
Universiti Teknologi MARA (Kampus Puncak Alam) |
| granting_department |
Faculty of Pharmacy |
| publishDate |
2008 |
| url |
https://ir.uitm.edu.my/id/eprint/101880/1/101880.PDF |
| _version_ |
1811769194537025536 |