Microscopic characterisation of spheroids / Zawiah Ahmad

The influence of microwave treatment on spheroid pore and surface characteristics against drug release profile was investigated. The spheroids were prepared by extrusion spheronization process followed by drying in hot air oven. Both blank and drug loaded spheroids were treated by microwave. The ph...

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Bibliographic Details
Main Author:	Ahmad, Zawiah
Format:	Thesis
Language:	English
Published:	2008
Subjects:	Pharmaceutical dosage forms Pharmaceutical chemistry
Online Access:	https://ir.uitm.edu.my/id/eprint/101880/1/101880.PDF
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id	my-uitm-ir.101880
record_format	uketd_dc
spelling	my-uitm-ir.1018802024-09-28T23:26:54Z Microscopic characterisation of spheroids / Zawiah Ahmad 2008 Ahmad, Zawiah Pharmaceutical dosage forms Pharmaceutical chemistry The influence of microwave treatment on spheroid pore and surface characteristics against drug release profile was investigated. The spheroids were prepared by extrusion spheronization process followed by drying in hot air oven. Both blank and drug loaded spheroids were treated by microwave. The physical changes of spheroids were observed microscopically using a stereo microscope to observe the changes before and after spheroids subjecting to microwave treatment. Drug release profile was determined by performing drug dissolution test for both untreated and treated spheroids. Microwave treatment changed pore and surface characteristics of spheroids. However, an increase in drug dissolution of microwave treated spheroids did not necessary accompany by an increase in pore population of spheroids. Other factors such as drug-polymer interaction, polymer-polymer interaction, polymorphism and crystallinity of drugs, could have roles in drug dissolution. 2008 Thesis https://ir.uitm.edu.my/id/eprint/101880/ https://ir.uitm.edu.my/id/eprint/101880/1/101880.PDF text en public degree Universiti Teknologi MARA (Kampus Puncak Alam) Faculty of Pharmacy Wui, Wong Tin
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
advisor	Wui, Wong Tin
topic	Pharmaceutical dosage forms Pharmaceutical chemistry
spellingShingle	Pharmaceutical dosage forms Pharmaceutical chemistry Ahmad, Zawiah Microscopic characterisation of spheroids / Zawiah Ahmad
description	The influence of microwave treatment on spheroid pore and surface characteristics against drug release profile was investigated. The spheroids were prepared by extrusion spheronization process followed by drying in hot air oven. Both blank and drug loaded spheroids were treated by microwave. The physical changes of spheroids were observed microscopically using a stereo microscope to observe the changes before and after spheroids subjecting to microwave treatment. Drug release profile was determined by performing drug dissolution test for both untreated and treated spheroids. Microwave treatment changed pore and surface characteristics of spheroids. However, an increase in drug dissolution of microwave treated spheroids did not necessary accompany by an increase in pore population of spheroids. Other factors such as drug-polymer interaction, polymer-polymer interaction, polymorphism and crystallinity of drugs, could have roles in drug dissolution.
format	Thesis
qualification_level	Bachelor degree
author	Ahmad, Zawiah
author_facet	Ahmad, Zawiah
author_sort	Ahmad, Zawiah
title	Microscopic characterisation of spheroids / Zawiah Ahmad
title_short	Microscopic characterisation of spheroids / Zawiah Ahmad
title_full	Microscopic characterisation of spheroids / Zawiah Ahmad
title_fullStr	Microscopic characterisation of spheroids / Zawiah Ahmad
title_full_unstemmed	Microscopic characterisation of spheroids / Zawiah Ahmad
title_sort	microscopic characterisation of spheroids / zawiah ahmad
granting_institution	Universiti Teknologi MARA (Kampus Puncak Alam)
granting_department	Faculty of Pharmacy
publishDate	2008
url	https://ir.uitm.edu.my/id/eprint/101880/1/101880.PDF
_version_	1811769194537025536

Microscopic characterisation of spheroids / Zawiah Ahmad

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