Formulation & optimization of long chain fatty acid nanoemulsion using high pressure homogenizer / Mohd Hafizi Mohamaddan

Nanoemulsion is a class of emulsions with small, uniformly distributed droplets particle size in the range of 20-500 nm. Nanoemulsions are not thermodynamically stable and their characteristics will depend on the preparation method. One the most common method used to produce nano-emulsion in pharmac...

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Main Author:	Mohamaddan, Mohd Hafizi
Format:	Thesis
Language:	English
Published:	2008
Subjects:	Organic materia medica (General) Pharmaceutical chemistry
Online Access:	https://ir.uitm.edu.my/id/eprint/101905/1/101905.PDF
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id	my-uitm-ir.101905
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spelling	my-uitm-ir.1019052024-09-28T23:34:45Z Formulation & optimization of long chain fatty acid nanoemulsion using high pressure homogenizer / Mohd Hafizi Mohamaddan 2008 Mohamaddan, Mohd Hafizi Organic materia medica (General) Pharmacognosy. Pharmaceutical substances (Plant, animal, and inorganic) Pharmaceutical chemistry Nanoemulsion is a class of emulsions with small, uniformly distributed droplets particle size in the range of 20-500 nm. Nanoemulsions are not thermodynamically stable and their characteristics will depend on the preparation method. One the most common method used to produce nano-emulsion in pharmaceutical industry is by the application of high pressure homogenizer (HPH). Olive oil has many good benefits for health as well as advantages in pharmaceutical application. Olive oil emulsion is one of the products available in the market for the various heath purposes. However, the olive oil nanoemulsion when compared to Olive oil emulsion has good stability and many pharmaceutical advantages such as efficient delivery of active ingredients. Thus, the aim of this study is to investigate the formulation and determination of homogenization processing parameters of the HPH for the optimization of olive oil nanoemulsion. Initial study to obtain good formulation was done by using Tween 80, Span 80, olive oil and water. Once the formulation was obtained, the pre-mixing optimization of the emulsion was studied at the various speeds of the homogenizer and the pre-mixing time. As the speed of the homogenizer and pre-mixing time increase, the droplets particle size measured by using the Mastersizer become smaller and uniform, From this study, the best and suitable homogenizer speed and pre-mixing time was chosen. Then, the pre mixing emulsion was submitted into the HPH and the optimization study of influence of various HPH parameters carried out. The HPH parameters are the effect of the different pressures of HPH and passing time (cycle number) to the droplets particle size and uniformity of the nanoemulsion. The result showed that as the pressure and cycle number increase, the droplets particle size of the Olive nanoemulsion will become smaller and more uniform. The stability study of olive oil nanoemulsion produced was carried show a good stability and shows no phase separation. Thus, the good olive oil nanoemulsion can be produced by using the high pressure homogenizer. 2008 Thesis https://ir.uitm.edu.my/id/eprint/101905/ https://ir.uitm.edu.my/id/eprint/101905/1/101905.PDF text en public degree Universiti Teknologi MARA (Kampus Puncak Alam) Faculty of Pharmacy Mustafa, Ahmad
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
advisor	Mustafa, Ahmad
topic	Organic materia medica (General) Organic materia medica (General) Pharmaceutical chemistry
spellingShingle	Organic materia medica (General) Organic materia medica (General) Pharmaceutical chemistry Mohamaddan, Mohd Hafizi Formulation & optimization of long chain fatty acid nanoemulsion using high pressure homogenizer / Mohd Hafizi Mohamaddan
description	Nanoemulsion is a class of emulsions with small, uniformly distributed droplets particle size in the range of 20-500 nm. Nanoemulsions are not thermodynamically stable and their characteristics will depend on the preparation method. One the most common method used to produce nano-emulsion in pharmaceutical industry is by the application of high pressure homogenizer (HPH). Olive oil has many good benefits for health as well as advantages in pharmaceutical application. Olive oil emulsion is one of the products available in the market for the various heath purposes. However, the olive oil nanoemulsion when compared to Olive oil emulsion has good stability and many pharmaceutical advantages such as efficient delivery of active ingredients. Thus, the aim of this study is to investigate the formulation and determination of homogenization processing parameters of the HPH for the optimization of olive oil nanoemulsion. Initial study to obtain good formulation was done by using Tween 80, Span 80, olive oil and water. Once the formulation was obtained, the pre-mixing optimization of the emulsion was studied at the various speeds of the homogenizer and the pre-mixing time. As the speed of the homogenizer and pre-mixing time increase, the droplets particle size measured by using the Mastersizer become smaller and uniform, From this study, the best and suitable homogenizer speed and pre-mixing time was chosen. Then, the pre mixing emulsion was submitted into the HPH and the optimization study of influence of various HPH parameters carried out. The HPH parameters are the effect of the different pressures of HPH and passing time (cycle number) to the droplets particle size and uniformity of the nanoemulsion. The result showed that as the pressure and cycle number increase, the droplets particle size of the Olive nanoemulsion will become smaller and more uniform. The stability study of olive oil nanoemulsion produced was carried show a good stability and shows no phase separation. Thus, the good olive oil nanoemulsion can be produced by using the high pressure homogenizer.
format	Thesis
qualification_level	Bachelor degree
author	Mohamaddan, Mohd Hafizi
author_facet	Mohamaddan, Mohd Hafizi
author_sort	Mohamaddan, Mohd Hafizi
title	Formulation & optimization of long chain fatty acid nanoemulsion using high pressure homogenizer / Mohd Hafizi Mohamaddan
title_short	Formulation & optimization of long chain fatty acid nanoemulsion using high pressure homogenizer / Mohd Hafizi Mohamaddan
title_full	Formulation & optimization of long chain fatty acid nanoemulsion using high pressure homogenizer / Mohd Hafizi Mohamaddan
title_fullStr	Formulation & optimization of long chain fatty acid nanoemulsion using high pressure homogenizer / Mohd Hafizi Mohamaddan
title_full_unstemmed	Formulation & optimization of long chain fatty acid nanoemulsion using high pressure homogenizer / Mohd Hafizi Mohamaddan
title_sort	formulation & optimization of long chain fatty acid nanoemulsion using high pressure homogenizer / mohd hafizi mohamaddan
granting_institution	Universiti Teknologi MARA (Kampus Puncak Alam)
granting_department	Faculty of Pharmacy
publishDate	2008
url	https://ir.uitm.edu.my/id/eprint/101905/1/101905.PDF
_version_	1811769198639054848

Formulation & optimization of long chain fatty acid nanoemulsion using high pressure homogenizer / Mohd Hafizi Mohamaddan

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