Coumarins - fast synthesis by the knoevenagel condensation under microwave irradiation / Rahmat Mohamed Tahir

Coumarin nowadays is of great importance especially in the area of pharmaceutical. Therefore, a faster way of producing coumarin was needed while maintaining the purity and yields of product as high as possible. One of the methods is Knoevenagel condensation under microwave assisted irradiation. Thi...

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Main Author:	Mohamed Tahir, Rahmat
Format:	Thesis
Language:	English
Published:	2008
Subjects:	Pharmacopoeias Materia medica
Online Access:	https://ir.uitm.edu.my/id/eprint/101908/1/101908.PDF
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id	my-uitm-ir.101908
record_format	uketd_dc
spelling	my-uitm-ir.1019082024-09-28T23:34:49Z Coumarins - fast synthesis by the knoevenagel condensation under microwave irradiation / Rahmat Mohamed Tahir 2008 Mohamed Tahir, Rahmat Pharmacopoeias Materia medica Coumarin nowadays is of great importance especially in the area of pharmaceutical. Therefore, a faster way of producing coumarin was needed while maintaining the purity and yields of product as high as possible. One of the methods is Knoevenagel condensation under microwave assisted irradiation. This research was aimed to prove that under the microwave irradiation the Knoevenagel condensation can be successfully applied to the synthesis of a number of coumarins. Also, the researcher wanted to find the most suitable base for this reaction. 2-hydroxy-4-methoxy benzaldehyde and 2- hydroxy-5-methoxy benzaldehyde were reacted with diethyl melonate in the presence of three different bases; diethylamine, pyridine, and potassium tert-butoxide for three different reactions. The reactions were set under different conditions: stirring with no heating for six hours; stirring with heating at 80°C for six hours; and under microwave assisted irradiation at 1000 watt power, 70°C, and stirring speed of I 00 rpm for one hour. TLC was used to prove the reactions were completed. To confirm the structure of coumarins (13 and 16) formed, 1H and 13C-NMR analyses were used. From the results, it was found out that diethylamine was the most suitable base for this reaction therefore used throughout the research. Productions of coumarins were significantly increased from stirring, no heating condition (29.07 % and 61.13 %) to stirring, heating condition (39.52 % and 68.23 %) to microwave assisted irradiation (48.39 % and 84.68 %). The time for reaction under microwave condition was also decreased to one hour and yet the percentage yield was still maintained. 2008 Thesis https://ir.uitm.edu.my/id/eprint/101908/ https://ir.uitm.edu.my/id/eprint/101908/1/101908.PDF text en public degree Universiti Teknologi MARA (Kampus Puncak Alam) Faculty of Pharmacy Naz, Humera
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
advisor	Naz, Humera
topic	Pharmacopoeias Materia medica
spellingShingle	Pharmacopoeias Materia medica Mohamed Tahir, Rahmat Coumarins - fast synthesis by the knoevenagel condensation under microwave irradiation / Rahmat Mohamed Tahir
description	Coumarin nowadays is of great importance especially in the area of pharmaceutical. Therefore, a faster way of producing coumarin was needed while maintaining the purity and yields of product as high as possible. One of the methods is Knoevenagel condensation under microwave assisted irradiation. This research was aimed to prove that under the microwave irradiation the Knoevenagel condensation can be successfully applied to the synthesis of a number of coumarins. Also, the researcher wanted to find the most suitable base for this reaction. 2-hydroxy-4-methoxy benzaldehyde and 2- hydroxy-5-methoxy benzaldehyde were reacted with diethyl melonate in the presence of three different bases; diethylamine, pyridine, and potassium tert-butoxide for three different reactions. The reactions were set under different conditions: stirring with no heating for six hours; stirring with heating at 80°C for six hours; and under microwave assisted irradiation at 1000 watt power, 70°C, and stirring speed of I 00 rpm for one hour. TLC was used to prove the reactions were completed. To confirm the structure of coumarins (13 and 16) formed, 1H and 13C-NMR analyses were used. From the results, it was found out that diethylamine was the most suitable base for this reaction therefore used throughout the research. Productions of coumarins were significantly increased from stirring, no heating condition (29.07 % and 61.13 %) to stirring, heating condition (39.52 % and 68.23 %) to microwave assisted irradiation (48.39 % and 84.68 %). The time for reaction under microwave condition was also decreased to one hour and yet the percentage yield was still maintained.
format	Thesis
qualification_level	Bachelor degree
author	Mohamed Tahir, Rahmat
author_facet	Mohamed Tahir, Rahmat
author_sort	Mohamed Tahir, Rahmat
title	Coumarins - fast synthesis by the knoevenagel condensation under microwave irradiation / Rahmat Mohamed Tahir
title_short	Coumarins - fast synthesis by the knoevenagel condensation under microwave irradiation / Rahmat Mohamed Tahir
title_full	Coumarins - fast synthesis by the knoevenagel condensation under microwave irradiation / Rahmat Mohamed Tahir
title_fullStr	Coumarins - fast synthesis by the knoevenagel condensation under microwave irradiation / Rahmat Mohamed Tahir
title_full_unstemmed	Coumarins - fast synthesis by the knoevenagel condensation under microwave irradiation / Rahmat Mohamed Tahir
title_sort	coumarins - fast synthesis by the knoevenagel condensation under microwave irradiation / rahmat mohamed tahir
granting_institution	Universiti Teknologi MARA (Kampus Puncak Alam)
granting_department	Faculty of Pharmacy
publishDate	2008
url	https://ir.uitm.edu.my/id/eprint/101908/1/101908.PDF
_version_	1811769199387738112

Coumarins - fast synthesis by the knoevenagel condensation under microwave irradiation / Rahmat Mohamed Tahir

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