Antinociceptive and anti-inflammatory properties of the aqueous extract of lignosus rhinocerus / Shahrul Reza Mohd Ghazali

A lot of researches are done to develop new synthetic drugs. However the synthetic products have many side effects that mostly affect the pediatrics and the geriatrics. Due to these unwanted side effects, recent studies have been shifted to emphasize more on natural products. Lignosus rhinocerus has...

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Main Author:	Mohd Ghazali, Shahrul Reza
Format:	Thesis
Language:	English
Published:	2008
Subjects:	Drugs and their actions Pharmaceutical supplies
Online Access:	https://ir.uitm.edu.my/id/eprint/101914/1/101914.PDF
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id	my-uitm-ir.101914
record_format	uketd_dc
spelling	my-uitm-ir.1019142024-09-11T19:17:33Z Antinociceptive and anti-inflammatory properties of the aqueous extract of lignosus rhinocerus / Shahrul Reza Mohd Ghazali 2008 Mohd Ghazali, Shahrul Reza Drugs and their actions Pharmaceutical supplies A lot of researches are done to develop new synthetic drugs. However the synthetic products have many side effects that mostly affect the pediatrics and the geriatrics. Due to these unwanted side effects, recent studies have been shifted to emphasize more on natural products. Lignosus rhinocerus has been utilized by traditional folks for several traditional claims such as for the treatment of cold, flu, cough, asthma and even cancer. Due to the fact that Lignosus rhinocerus grows wild in Malaysia and that adequate studies have not been carried out to explore the pharmaceutical benefits of this plants, we decided to evaluate and establish some of the basic pharmaceutical properties of Lignosus rhinocerus. The aim of this study is to evaluate and determine the antinociceptive and anti-inflammatory properties of aqueous extracts of Lignosus rhinocerus (AELR). The antinociceptive and anti-inflammatory property of AELR was examined using three different assays namely the abdominal constriction test, hot plate test, and formalin test. In the abdominal constriction test, 100% AELR showed significant effect on the peripheral antinociceptive mechanism. It was also shown that hot plate test produce positive outcome towards the central antinociceptive assay. Interestingly the effect in formalin early phase test was also inhibited by AELR. These present results demonstrated that the AELR was found to exhibit antinociceptive property via central and peripheral mechanism. In addition it was found that the late phase of formalin test was blocked by AELR which be the evidence for the anti-inflammatory property. Furthermore both antinociceptive and anti inflarnmatory effects of AELR showed concentration independent activity. It was proven that aqueous extracts of Lignosus rhinocerus have the antinociceptive and anti inflarnmatory properties. 2008 Thesis https://ir.uitm.edu.my/id/eprint/101914/ https://ir.uitm.edu.my/id/eprint/101914/1/101914.PDF text en public degree Universiti Teknologi MARA (Kampus Puncak Alam) Faculty of Pharmacy Zakaria, Zainul Amiruddin
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
advisor	Zakaria, Zainul Amiruddin
topic	Drugs and their actions Pharmaceutical supplies
spellingShingle	Drugs and their actions Pharmaceutical supplies Mohd Ghazali, Shahrul Reza Antinociceptive and anti-inflammatory properties of the aqueous extract of lignosus rhinocerus / Shahrul Reza Mohd Ghazali
description	A lot of researches are done to develop new synthetic drugs. However the synthetic products have many side effects that mostly affect the pediatrics and the geriatrics. Due to these unwanted side effects, recent studies have been shifted to emphasize more on natural products. Lignosus rhinocerus has been utilized by traditional folks for several traditional claims such as for the treatment of cold, flu, cough, asthma and even cancer. Due to the fact that Lignosus rhinocerus grows wild in Malaysia and that adequate studies have not been carried out to explore the pharmaceutical benefits of this plants, we decided to evaluate and establish some of the basic pharmaceutical properties of Lignosus rhinocerus. The aim of this study is to evaluate and determine the antinociceptive and anti-inflammatory properties of aqueous extracts of Lignosus rhinocerus (AELR). The antinociceptive and anti-inflammatory property of AELR was examined using three different assays namely the abdominal constriction test, hot plate test, and formalin test. In the abdominal constriction test, 100% AELR showed significant effect on the peripheral antinociceptive mechanism. It was also shown that hot plate test produce positive outcome towards the central antinociceptive assay. Interestingly the effect in formalin early phase test was also inhibited by AELR. These present results demonstrated that the AELR was found to exhibit antinociceptive property via central and peripheral mechanism. In addition it was found that the late phase of formalin test was blocked by AELR which be the evidence for the anti-inflammatory property. Furthermore both antinociceptive and anti inflarnmatory effects of AELR showed concentration independent activity. It was proven that aqueous extracts of Lignosus rhinocerus have the antinociceptive and anti inflarnmatory properties.
format	Thesis
qualification_level	Bachelor degree
author	Mohd Ghazali, Shahrul Reza
author_facet	Mohd Ghazali, Shahrul Reza
author_sort	Mohd Ghazali, Shahrul Reza
title	Antinociceptive and anti-inflammatory properties of the aqueous extract of lignosus rhinocerus / Shahrul Reza Mohd Ghazali
title_short	Antinociceptive and anti-inflammatory properties of the aqueous extract of lignosus rhinocerus / Shahrul Reza Mohd Ghazali
title_full	Antinociceptive and anti-inflammatory properties of the aqueous extract of lignosus rhinocerus / Shahrul Reza Mohd Ghazali
title_fullStr	Antinociceptive and anti-inflammatory properties of the aqueous extract of lignosus rhinocerus / Shahrul Reza Mohd Ghazali
title_full_unstemmed	Antinociceptive and anti-inflammatory properties of the aqueous extract of lignosus rhinocerus / Shahrul Reza Mohd Ghazali
title_sort	antinociceptive and anti-inflammatory properties of the aqueous extract of lignosus rhinocerus / shahrul reza mohd ghazali
granting_institution	Universiti Teknologi MARA (Kampus Puncak Alam)
granting_department	Faculty of Pharmacy
publishDate	2008
url	https://ir.uitm.edu.my/id/eprint/101914/1/101914.PDF
_version_	1811769200177315840

Antinociceptive and anti-inflammatory properties of the aqueous extract of lignosus rhinocerus / Shahrul Reza Mohd Ghazali

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