Synthesis of 12-benzyloxy-3,4- dimethoxy-13-methylstilbene and 12- acetoxy-3,4-dimethoxy-13-methylstilbene / Mohd Fadhli Razali

his research project aims to synthesize a stillbene analogues, 12-benzyloxy-3,4- dimethoxy-13-methylstilbene and 12-acetoxy-3,4-dimethoxy-13-stillbene via series of reactions. This study was carried out in four establish reactions. Firstly, the protection of hydroxyl group of 4-iodophenol, 1 by benz...

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Main Author:	Razali, Mohd Fadhli
Format:	Thesis
Language:	English
Published:	2008
Subjects:	Immunotherapy Serotherapy
Online Access:	https://ir.uitm.edu.my/id/eprint/102036/1/102036.PDF
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id	my-uitm-ir.102036
record_format	uketd_dc
spelling	my-uitm-ir.1020362024-09-11T19:22:03Z Synthesis of 12-benzyloxy-3,4- dimethoxy-13-methylstilbene and 12- acetoxy-3,4-dimethoxy-13-methylstilbene / Mohd Fadhli Razali 2008 Razali, Mohd Fadhli Immunotherapy. Serotherapy Pharmacognosy. Pharmaceutical substances (Plant, animal, and inorganic) his research project aims to synthesize a stillbene analogues, 12-benzyloxy-3,4- dimethoxy-13-methylstilbene and 12-acetoxy-3,4-dimethoxy-13-stillbene via series of reactions. This study was carried out in four establish reactions. Firstly, the protection of hydroxyl group of 4-iodophenol, 1 by benzylation and acetylation producing 4-iodo-2-methylphenylbenzylether, 2 and 4-iodo-2-methylphenylacetate, 3. Then, the product from both reaction is used to synthesize the desired compound, 12-benzyloxy-3,4-dimethoxy-13-methylstilbene, 5 and 12-acetoxy-3,4-dirnethoxy- 13-stillbene, 6 by Heck reaction involving the utilization of paladium (II) catalyst, triphenylphosphine ligand, argentum nitrate, potassium acetate and dirnethylformamide solvent. The products were purified by chromatographic technique using thin layer chromatography plate and Prep thin layer chromatography. NMR characterization also had been used in the determination of the structure. The reaction was succesful as both the tentative compound was successfully obtained. 12- benzyloxy-3,4-dimethoxy-13-methylstilbene, 5 and 12-acetoxy-3,4-dirnethoxy- l 3- stillbene, 6 has been synthesized in small amount (20.25% and 26.54% respectively). 2008 Thesis https://ir.uitm.edu.my/id/eprint/102036/ https://ir.uitm.edu.my/id/eprint/102036/1/102036.PDF text en public degree Universiti Teknologi MARA (Kampus Puncak Alam) Faculty of Pharmacy
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
topic	Immunotherapy Serotherapy Immunotherapy Serotherapy
spellingShingle	Immunotherapy Serotherapy Immunotherapy Serotherapy Razali, Mohd Fadhli Synthesis of 12-benzyloxy-3,4- dimethoxy-13-methylstilbene and 12- acetoxy-3,4-dimethoxy-13-methylstilbene / Mohd Fadhli Razali
description	his research project aims to synthesize a stillbene analogues, 12-benzyloxy-3,4- dimethoxy-13-methylstilbene and 12-acetoxy-3,4-dimethoxy-13-stillbene via series of reactions. This study was carried out in four establish reactions. Firstly, the protection of hydroxyl group of 4-iodophenol, 1 by benzylation and acetylation producing 4-iodo-2-methylphenylbenzylether, 2 and 4-iodo-2-methylphenylacetate, 3. Then, the product from both reaction is used to synthesize the desired compound, 12-benzyloxy-3,4-dimethoxy-13-methylstilbene, 5 and 12-acetoxy-3,4-dirnethoxy- 13-stillbene, 6 by Heck reaction involving the utilization of paladium (II) catalyst, triphenylphosphine ligand, argentum nitrate, potassium acetate and dirnethylformamide solvent. The products were purified by chromatographic technique using thin layer chromatography plate and Prep thin layer chromatography. NMR characterization also had been used in the determination of the structure. The reaction was succesful as both the tentative compound was successfully obtained. 12- benzyloxy-3,4-dimethoxy-13-methylstilbene, 5 and 12-acetoxy-3,4-dirnethoxy- l 3- stillbene, 6 has been synthesized in small amount (20.25% and 26.54% respectively).
format	Thesis
qualification_level	Bachelor degree
author	Razali, Mohd Fadhli
author_facet	Razali, Mohd Fadhli
author_sort	Razali, Mohd Fadhli
title	Synthesis of 12-benzyloxy-3,4- dimethoxy-13-methylstilbene and 12- acetoxy-3,4-dimethoxy-13-methylstilbene / Mohd Fadhli Razali
title_short	Synthesis of 12-benzyloxy-3,4- dimethoxy-13-methylstilbene and 12- acetoxy-3,4-dimethoxy-13-methylstilbene / Mohd Fadhli Razali
title_full	Synthesis of 12-benzyloxy-3,4- dimethoxy-13-methylstilbene and 12- acetoxy-3,4-dimethoxy-13-methylstilbene / Mohd Fadhli Razali
title_fullStr	Synthesis of 12-benzyloxy-3,4- dimethoxy-13-methylstilbene and 12- acetoxy-3,4-dimethoxy-13-methylstilbene / Mohd Fadhli Razali
title_full_unstemmed	Synthesis of 12-benzyloxy-3,4- dimethoxy-13-methylstilbene and 12- acetoxy-3,4-dimethoxy-13-methylstilbene / Mohd Fadhli Razali
title_sort	synthesis of 12-benzyloxy-3,4- dimethoxy-13-methylstilbene and 12- acetoxy-3,4-dimethoxy-13-methylstilbene / mohd fadhli razali
granting_institution	Universiti Teknologi MARA (Kampus Puncak Alam)
granting_department	Faculty of Pharmacy
publishDate	2008
url	https://ir.uitm.edu.my/id/eprint/102036/1/102036.PDF
_version_	1811769206519103488

Synthesis of 12-benzyloxy-3,4- dimethoxy-13-methylstilbene and 12- acetoxy-3,4-dimethoxy-13-methylstilbene / Mohd Fadhli Razali

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