Psynthesis of a substituted cyclohexenone via Michael addition and intramolecular aldol condensation (Robinson annulation) of chalcone with ethyl acetoacetate / Nor Aisah Uzairi

Ethyl 6-(4-methoxyphenyl)-4-phenylcyclohex-3-en-2-one-l-carboxylate was synthesized through Michael addition and intramolecular aldol condensation (Robinson annulation) of 4-methoxychalcone with ethyl acetoacetate using a strong base, natrium hydroxyde (NaOH) as catalyst. 4-mthoxychalcone was first...

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Main Author:	Uzairi, Nor Aisah
Format:	Thesis
Language:	English
Published:	2008
Online Access:	https://ir.uitm.edu.my/id/eprint/102106/1/102106.pdf
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id	my-uitm-ir.102106
record_format	uketd_dc
spelling	my-uitm-ir.1021062024-09-12T16:29:05Z Psynthesis of a substituted cyclohexenone via Michael addition and intramolecular aldol condensation (Robinson annulation) of chalcone with ethyl acetoacetate / Nor Aisah Uzairi 2008 Uzairi, Nor Aisah Ethyl 6-(4-methoxyphenyl)-4-phenylcyclohex-3-en-2-one-l-carboxylate was synthesized through Michael addition and intramolecular aldol condensation (Robinson annulation) of 4-methoxychalcone with ethyl acetoacetate using a strong base, natrium hydroxyde (NaOH) as catalyst. 4-mthoxychalcone was first prepared by aldol condensation of 4-methoxybenzaldehyde and acetophenone. The percentage yield of 4- methoxychalcone was 98.65% and its melting point is 74-75°C. Then 4-Methoxychalcone was reacted with ethyl acetoacetate through Michael addition and aldol cyclization to form the final substituted cyclohexenone product in 79% yield. The melting point of the substituted cyclohexenone product is 108 - 110°C. 2008 Thesis https://ir.uitm.edu.my/id/eprint/102106/ https://ir.uitm.edu.my/id/eprint/102106/1/102106.pdf text en public degree Universiti Teknologi MARA (UiTM) Faculty of Applied Sciences -, Yazan
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
advisor	-, Yazan
description	Ethyl 6-(4-methoxyphenyl)-4-phenylcyclohex-3-en-2-one-l-carboxylate was synthesized through Michael addition and intramolecular aldol condensation (Robinson annulation) of 4-methoxychalcone with ethyl acetoacetate using a strong base, natrium hydroxyde (NaOH) as catalyst. 4-mthoxychalcone was first prepared by aldol condensation of 4-methoxybenzaldehyde and acetophenone. The percentage yield of 4- methoxychalcone was 98.65% and its melting point is 74-75°C. Then 4-Methoxychalcone was reacted with ethyl acetoacetate through Michael addition and aldol cyclization to form the final substituted cyclohexenone product in 79% yield. The melting point of the substituted cyclohexenone product is 108 - 110°C.
format	Thesis
qualification_level	Bachelor degree
author	Uzairi, Nor Aisah
spellingShingle	Uzairi, Nor Aisah Psynthesis of a substituted cyclohexenone via Michael addition and intramolecular aldol condensation (Robinson annulation) of chalcone with ethyl acetoacetate / Nor Aisah Uzairi
author_facet	Uzairi, Nor Aisah
author_sort	Uzairi, Nor Aisah
title	Psynthesis of a substituted cyclohexenone via Michael addition and intramolecular aldol condensation (Robinson annulation) of chalcone with ethyl acetoacetate / Nor Aisah Uzairi
title_short	Psynthesis of a substituted cyclohexenone via Michael addition and intramolecular aldol condensation (Robinson annulation) of chalcone with ethyl acetoacetate / Nor Aisah Uzairi
title_full	Psynthesis of a substituted cyclohexenone via Michael addition and intramolecular aldol condensation (Robinson annulation) of chalcone with ethyl acetoacetate / Nor Aisah Uzairi
title_fullStr	Psynthesis of a substituted cyclohexenone via Michael addition and intramolecular aldol condensation (Robinson annulation) of chalcone with ethyl acetoacetate / Nor Aisah Uzairi
title_full_unstemmed	Psynthesis of a substituted cyclohexenone via Michael addition and intramolecular aldol condensation (Robinson annulation) of chalcone with ethyl acetoacetate / Nor Aisah Uzairi
title_sort	psynthesis of a substituted cyclohexenone via michael addition and intramolecular aldol condensation (robinson annulation) of chalcone with ethyl acetoacetate / nor aisah uzairi
granting_institution	Universiti Teknologi MARA (UiTM)
granting_department	Faculty of Applied Sciences
publishDate	2008
url	https://ir.uitm.edu.my/id/eprint/102106/1/102106.pdf
_version_	1811769208810242048

Psynthesis of a substituted cyclohexenone via Michael addition and intramolecular aldol condensation (Robinson annulation) of chalcone with ethyl acetoacetate / Nor Aisah Uzairi

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