Systematic review and meta-analysis of hepatoprotective probiotics in vivo and elucidation of Lactiplantibacillus plantarum LAB12-induced hepatoprotection against high-fat diet-induced metabolic dysfunction-associated fatty liver disease mouse model via the gut-liver axis / Faezah Sabirin

Metabolic dysfunction-associated fatty liver disease (MAFLD), previously known as non-alcoholic fatty liver disease (NAFLD), is a highly prevalent disease. To date, lifestyle modifications remain as the cornerstone for MAFLD management. During advanced stage of the disease, patients are prescribed w...

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Main Author:	Sabirin, Faezah
Format:	Thesis
Language:	English
Published:	2023
Subjects:	Diseases of the digestive system Gastroenterology
Online Access:	https://ir.uitm.edu.my/id/eprint/102192/1/102192.pdf
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id	my-uitm-ir.102192
record_format	uketd_dc
spelling	my-uitm-ir.1021922024-11-12T06:46:30Z Systematic review and meta-analysis of hepatoprotective probiotics in vivo and elucidation of Lactiplantibacillus plantarum LAB12-induced hepatoprotection against high-fat diet-induced metabolic dysfunction-associated fatty liver disease mouse model via the gut-liver axis / Faezah Sabirin 2023 Sabirin, Faezah Diseases of the digestive system. Gastroenterology Metabolic dysfunction-associated fatty liver disease (MAFLD), previously known as non-alcoholic fatty liver disease (NAFLD), is a highly prevalent disease. To date, lifestyle modifications remain as the cornerstone for MAFLD management. During advanced stage of the disease, patients are prescribed with either vitamin E (i.e., αtocopherol) or pioglitazone. Whilst the problems of lifestyle changes are associated with poor implementation and compliance, pharmacological therapies result in limited improvement of liver pathology and are often compromised by side effects. This raises the need for effective alternatives that are relatively easier to comply with and emerging functional food like probiotics appear to fit the bill given their increasingly recognised roles in delaying the progression of MAFLD. As such, this study had first systematically reviewed publications on hepatoprotection of probiotics in vivo based on the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines. The literature search, which was performed through the Cochrane Library, EMBASE, PubMed/ Medline and Web of Science by using pre-defined keywords, had identified 4,841 studies, from which 53 were shortlisted based on the inclusion and exclusion criteria. All shortlisted studies for qualitative appraisal were presented with low/ unclear risk of bias. Only 24 studies were eligible for subsequent quantitative analysis using Review Manager Version 5.3. 2023 Thesis https://ir.uitm.edu.my/id/eprint/102192/ https://ir.uitm.edu.my/id/eprint/102192/1/102192.pdf text en public phd doctoral Universiti Teknologi MARA (UiTM) Faculty of Pharmacy Ramasamy, Kalavathy
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
advisor	Ramasamy, Kalavathy
topic	Diseases of the digestive system Gastroenterology
spellingShingle	Diseases of the digestive system Gastroenterology Sabirin, Faezah Systematic review and meta-analysis of hepatoprotective probiotics in vivo and elucidation of Lactiplantibacillus plantarum LAB12-induced hepatoprotection against high-fat diet-induced metabolic dysfunction-associated fatty liver disease mouse model via the gut-liver axis / Faezah Sabirin
description	Metabolic dysfunction-associated fatty liver disease (MAFLD), previously known as non-alcoholic fatty liver disease (NAFLD), is a highly prevalent disease. To date, lifestyle modifications remain as the cornerstone for MAFLD management. During advanced stage of the disease, patients are prescribed with either vitamin E (i.e., αtocopherol) or pioglitazone. Whilst the problems of lifestyle changes are associated with poor implementation and compliance, pharmacological therapies result in limited improvement of liver pathology and are often compromised by side effects. This raises the need for effective alternatives that are relatively easier to comply with and emerging functional food like probiotics appear to fit the bill given their increasingly recognised roles in delaying the progression of MAFLD. As such, this study had first systematically reviewed publications on hepatoprotection of probiotics in vivo based on the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines. The literature search, which was performed through the Cochrane Library, EMBASE, PubMed/ Medline and Web of Science by using pre-defined keywords, had identified 4,841 studies, from which 53 were shortlisted based on the inclusion and exclusion criteria. All shortlisted studies for qualitative appraisal were presented with low/ unclear risk of bias. Only 24 studies were eligible for subsequent quantitative analysis using Review Manager Version 5.3.
format	Thesis
qualification_name	Doctor of Philosophy (PhD.)
qualification_level	Doctorate
author	Sabirin, Faezah
author_facet	Sabirin, Faezah
author_sort	Sabirin, Faezah
title	Systematic review and meta-analysis of hepatoprotective probiotics in vivo and elucidation of Lactiplantibacillus plantarum LAB12-induced hepatoprotection against high-fat diet-induced metabolic dysfunction-associated fatty liver disease mouse model via the gut-liver axis / Faezah Sabirin
title_short	Systematic review and meta-analysis of hepatoprotective probiotics in vivo and elucidation of Lactiplantibacillus plantarum LAB12-induced hepatoprotection against high-fat diet-induced metabolic dysfunction-associated fatty liver disease mouse model via the gut-liver axis / Faezah Sabirin
title_full	Systematic review and meta-analysis of hepatoprotective probiotics in vivo and elucidation of Lactiplantibacillus plantarum LAB12-induced hepatoprotection against high-fat diet-induced metabolic dysfunction-associated fatty liver disease mouse model via the gut-liver axis / Faezah Sabirin
title_fullStr	Systematic review and meta-analysis of hepatoprotective probiotics in vivo and elucidation of Lactiplantibacillus plantarum LAB12-induced hepatoprotection against high-fat diet-induced metabolic dysfunction-associated fatty liver disease mouse model via the gut-liver axis / Faezah Sabirin
title_full_unstemmed	Systematic review and meta-analysis of hepatoprotective probiotics in vivo and elucidation of Lactiplantibacillus plantarum LAB12-induced hepatoprotection against high-fat diet-induced metabolic dysfunction-associated fatty liver disease mouse model via the gut-liver axis / Faezah Sabirin
title_sort	systematic review and meta-analysis of hepatoprotective probiotics in vivo and elucidation of lactiplantibacillus plantarum lab12-induced hepatoprotection against high-fat diet-induced metabolic dysfunction-associated fatty liver disease mouse model via the gut-liver axis / faezah sabirin
granting_institution	Universiti Teknologi MARA (UiTM)
granting_department	Faculty of Pharmacy
publishDate	2023
url	https://ir.uitm.edu.my/id/eprint/102192/1/102192.pdf
_version_	1818588033723662336

Systematic review and meta-analysis of hepatoprotective probiotics in vivo and elucidation of Lactiplantibacillus plantarum LAB12-induced hepatoprotection against high-fat diet-induced metabolic dysfunction-associated fatty liver disease mouse model via the gut-liver axis / Faezah Sabirin

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