Male juvenile rats gene expression in sexually dimorphic brain region after exposure to Bisphenol A (BPA) / Nur Ezzati A. Rahman

In higher vertebrates, estrogen can exert an organizational effect on sexually dimorphic areas of the central nervous system (CNS) during postnatal phase of development. The possibility that estrogenic pollutants may mimic estrogen action on the CNS during development and produce long- lasting or ir...

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Main Author:	A. Rahman, Nur Ezzati
Format:	Thesis
Language:	English
Published:	2009
Subjects:	Pharmacognosy Pharmaceutical substances (Plant, animal, and inorganic)
Online Access:	https://ir.uitm.edu.my/id/eprint/105119/1/105119.PDF
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id	my-uitm-ir.105119
record_format	uketd_dc
spelling	my-uitm-ir.1051192024-10-24T01:44:16Z Male juvenile rats gene expression in sexually dimorphic brain region after exposure to Bisphenol A (BPA) / Nur Ezzati A. Rahman 2009 A. Rahman, Nur Ezzati Pharmacognosy. Pharmaceutical substances (Plant, animal, and inorganic) In higher vertebrates, estrogen can exert an organizational effect on sexually dimorphic areas of the central nervous system (CNS) during postnatal phase of development. The possibility that estrogenic pollutants may mimic estrogen action on the CNS during development and produce long- lasting or irreversible effects is an issue of great concern. Bisphenol A (BPA), which is commonly ingested by humans, is one of the estrogenic pollutants. This study determined the potential effect of BP A 100 mg/kg/day in a model of male juvenile Sprague-Dawley rats. In order to evaluate this effect, the male juvenile Sprague-Dawley rats have been fed orally with BP A 100 mg/kg/day, in different periods of time which are 7 days, 14 days and 28 days. Ethinyl estradiol 10 µg/kg bw was used as the positive control. The body weight and brain weight of male juvenile Sprague-Dawley rats, which were treated with BP A 100 mg/kg/day are increased drastically as the day of treatment increase, when compared to positive control. These findings showed that postnatal BPA exposure for a long period of time may alter the body weight and brain weight significantly. 2009 Thesis https://ir.uitm.edu.my/id/eprint/105119/ https://ir.uitm.edu.my/id/eprint/105119/1/105119.PDF text en public degree Universiti Teknologi MARA (Kampus Puncak Alam) Faculty of Pharmacy Surindar Singh, Gurmeet Kaur
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
advisor	Surindar Singh, Gurmeet Kaur
topic	Pharmacognosy Pharmaceutical substances (Plant, animal, and inorganic)
spellingShingle	Pharmacognosy Pharmaceutical substances (Plant, animal, and inorganic) A. Rahman, Nur Ezzati Male juvenile rats gene expression in sexually dimorphic brain region after exposure to Bisphenol A (BPA) / Nur Ezzati A. Rahman
description	In higher vertebrates, estrogen can exert an organizational effect on sexually dimorphic areas of the central nervous system (CNS) during postnatal phase of development. The possibility that estrogenic pollutants may mimic estrogen action on the CNS during development and produce long- lasting or irreversible effects is an issue of great concern. Bisphenol A (BPA), which is commonly ingested by humans, is one of the estrogenic pollutants. This study determined the potential effect of BP A 100 mg/kg/day in a model of male juvenile Sprague-Dawley rats. In order to evaluate this effect, the male juvenile Sprague-Dawley rats have been fed orally with BP A 100 mg/kg/day, in different periods of time which are 7 days, 14 days and 28 days. Ethinyl estradiol 10 µg/kg bw was used as the positive control. The body weight and brain weight of male juvenile Sprague-Dawley rats, which were treated with BP A 100 mg/kg/day are increased drastically as the day of treatment increase, when compared to positive control. These findings showed that postnatal BPA exposure for a long period of time may alter the body weight and brain weight significantly.
format	Thesis
qualification_level	Bachelor degree
author	A. Rahman, Nur Ezzati
author_facet	A. Rahman, Nur Ezzati
author_sort	A. Rahman, Nur Ezzati
title	Male juvenile rats gene expression in sexually dimorphic brain region after exposure to Bisphenol A (BPA) / Nur Ezzati A. Rahman
title_short	Male juvenile rats gene expression in sexually dimorphic brain region after exposure to Bisphenol A (BPA) / Nur Ezzati A. Rahman
title_full	Male juvenile rats gene expression in sexually dimorphic brain region after exposure to Bisphenol A (BPA) / Nur Ezzati A. Rahman
title_fullStr	Male juvenile rats gene expression in sexually dimorphic brain region after exposure to Bisphenol A (BPA) / Nur Ezzati A. Rahman
title_full_unstemmed	Male juvenile rats gene expression in sexually dimorphic brain region after exposure to Bisphenol A (BPA) / Nur Ezzati A. Rahman
title_sort	male juvenile rats gene expression in sexually dimorphic brain region after exposure to bisphenol a (bpa) / nur ezzati a. rahman
granting_institution	Universiti Teknologi MARA (Kampus Puncak Alam)
granting_department	Faculty of Pharmacy
publishDate	2009
url	https://ir.uitm.edu.my/id/eprint/105119/1/105119.PDF
_version_	1818588136567996416

Male juvenile rats gene expression in sexually dimorphic brain region after exposure to Bisphenol A (BPA) / Nur Ezzati A. Rahman

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