Vaccine candidate analysis of the helminth onchocerca volvulus: a computational approach / Mohd Nazri Mustafa

Filarial nematode Onchocerca volvulus had been identified as the causative agent for river blindness, or onchocerciasis. A disease characterized by chronic skin and eye lesions. It is the world's second leading infectious cause of blindness. It is a major health problem in several tropical coun...

Full description

Saved in:

Bibliographic Details
Main Author:	Mustafa, Mohd Nazri
Format:	Thesis
Language:	English
Published:	2009
Subjects:	Pharmaceutical industry Pharmaceutical chemistry
Online Access:	https://ir.uitm.edu.my/id/eprint/105217/1/105217.PDF
Tags:	Add Tag No Tags, Be the first to tag this record!

id	my-uitm-ir.105217
record_format	uketd_dc
spelling	my-uitm-ir.1052172024-12-05T09:00:20Z Vaccine candidate analysis of the helminth onchocerca volvulus: a computational approach / Mohd Nazri Mustafa 2009 Mustafa, Mohd Nazri Pharmaceutical industry Pharmaceutical chemistry Filarial nematode Onchocerca volvulus had been identified as the causative agent for river blindness, or onchocerciasis. A disease characterized by chronic skin and eye lesions. It is the world's second leading infectious cause of blindness. It is a major health problem in several tropical countries, mostly in Africa, south of the Sahara. More than 18 million persons are infected with this nematode. Discovery of primary FAR1_ONCVO gene in Onchocerca volvulus may provide us a deeper insight into vaccine development for river blindness. In this study, the identification of FAR1_ONCVO gene in Onchocerca volvulus was reported using in silica prediction approaches. FAR1_ONCVO gene of Onchocerca volvulus consists of 178 amino acids length. The predicted value of both pl and Mw of FAR1_ONCVO protein is 8.58 and 20580.81 Da, respectively. Prediction of secondary structure of Onchocerca volvulus FAR1_ONCVO protein revealed that it consists of 80.34% a-helix, 1.12% P-strand and 18.54% loop. Grand average of hydropathicity (GRAVY) is -0.516. Hence, Onchocerca volvulus FAR1_ONCVO protein is hydrophilic in nature. From the analyzed result, most of the protein sequences of Onchocerca volvulus FFAR1_ONCVO are located in extracellular cell. The region of "LRNFVKAKI" and "VIMANVVPF" which is at position 86 and 12 of FAR1_ONCVO protein sequences was predicted to have high potential candidate as promiscuous binders. In conclusion, the information obtained from in silica analysis of FAR1_ONCVO gene would then provide preliminary information for vaccine study. 2009 Thesis https://ir.uitm.edu.my/id/eprint/105217/ https://ir.uitm.edu.my/id/eprint/105217/1/105217.PDF text en public degree Universiti Teknologi MARA (Kampus Puncak Alam) Faculty of Pharmacy Leow, Chiuan Yee
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
advisor	Leow, Chiuan Yee
topic	Pharmaceutical industry Pharmaceutical chemistry
spellingShingle	Pharmaceutical industry Pharmaceutical chemistry Mustafa, Mohd Nazri Vaccine candidate analysis of the helminth onchocerca volvulus: a computational approach / Mohd Nazri Mustafa
description	Filarial nematode Onchocerca volvulus had been identified as the causative agent for river blindness, or onchocerciasis. A disease characterized by chronic skin and eye lesions. It is the world's second leading infectious cause of blindness. It is a major health problem in several tropical countries, mostly in Africa, south of the Sahara. More than 18 million persons are infected with this nematode. Discovery of primary FAR1_ONCVO gene in Onchocerca volvulus may provide us a deeper insight into vaccine development for river blindness. In this study, the identification of FAR1_ONCVO gene in Onchocerca volvulus was reported using in silica prediction approaches. FAR1_ONCVO gene of Onchocerca volvulus consists of 178 amino acids length. The predicted value of both pl and Mw of FAR1_ONCVO protein is 8.58 and 20580.81 Da, respectively. Prediction of secondary structure of Onchocerca volvulus FAR1_ONCVO protein revealed that it consists of 80.34% a-helix, 1.12% P-strand and 18.54% loop. Grand average of hydropathicity (GRAVY) is -0.516. Hence, Onchocerca volvulus FAR1_ONCVO protein is hydrophilic in nature. From the analyzed result, most of the protein sequences of Onchocerca volvulus FFAR1_ONCVO are located in extracellular cell. The region of "LRNFVKAKI" and "VIMANVVPF" which is at position 86 and 12 of FAR1_ONCVO protein sequences was predicted to have high potential candidate as promiscuous binders. In conclusion, the information obtained from in silica analysis of FAR1_ONCVO gene would then provide preliminary information for vaccine study.
format	Thesis
qualification_level	Bachelor degree
author	Mustafa, Mohd Nazri
author_facet	Mustafa, Mohd Nazri
author_sort	Mustafa, Mohd Nazri
title	Vaccine candidate analysis of the helminth onchocerca volvulus: a computational approach / Mohd Nazri Mustafa
title_short	Vaccine candidate analysis of the helminth onchocerca volvulus: a computational approach / Mohd Nazri Mustafa
title_full	Vaccine candidate analysis of the helminth onchocerca volvulus: a computational approach / Mohd Nazri Mustafa
title_fullStr	Vaccine candidate analysis of the helminth onchocerca volvulus: a computational approach / Mohd Nazri Mustafa
title_full_unstemmed	Vaccine candidate analysis of the helminth onchocerca volvulus: a computational approach / Mohd Nazri Mustafa
title_sort	vaccine candidate analysis of the helminth onchocerca volvulus: a computational approach / mohd nazri mustafa
granting_institution	Universiti Teknologi MARA (Kampus Puncak Alam)
granting_department	Faculty of Pharmacy
publishDate	2009
url	https://ir.uitm.edu.my/id/eprint/105217/1/105217.PDF
_version_	1818588140764397568

Vaccine candidate analysis of the helminth onchocerca volvulus: a computational approach / Mohd Nazri Mustafa

Similar Items