Structure-based drug modeling of curcuma longa as alternative drug for breast cancer / Maryam Jamilah Laharadi @ Lahuri

Overexpression of epidermal growth factor (EGFR) tyrosine kinase was related to occurance, lymph metastasis and pathologic types of breast cancer. lnhibition of the EGFR tyrosine kinase activity by small molecules has proved effective for the treatment of breast cancer. Study has been done before wh...

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Main Author:	Laharadi @ Lahuri, Maryam Jamilah
Format:	Thesis
Language:	English
Published:	2009
Subjects:	Pharmaceutical industry Pharmaceutical dosage forms Pharmaceutical chemistry
Online Access:	https://ir.uitm.edu.my/id/eprint/105244/1/105244.PDF
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id	my-uitm-ir.105244
record_format	uketd_dc
spelling	my-uitm-ir.1052442024-12-05T09:00:11Z Structure-based drug modeling of curcuma longa as alternative drug for breast cancer / Maryam Jamilah Laharadi @ Lahuri 2009 Laharadi @ Lahuri, Maryam Jamilah Pharmaceutical industry Pharmaceutical dosage forms Pharmaceutical chemistry Overexpression of epidermal growth factor (EGFR) tyrosine kinase was related to occurance, lymph metastasis and pathologic types of breast cancer. lnhibition of the EGFR tyrosine kinase activity by small molecules has proved effective for the treatment of breast cancer. Study has been done before where the crystal structure of EGFR has been used to identify inhibitor chemotypes by docking-based in silico screening of a large virtual chemical library followed up by experimental validation. Several compounds have been identified since then and one of them is Lapatinib which interact with EGFR coded in Protein Data Bank (PDB) as 1 xkk receptor. We analyzed the compound presence in Curcuma longa and identify the one that can give more or less similar effects such as Lapatinib through in silico models. 2009 Thesis https://ir.uitm.edu.my/id/eprint/105244/ https://ir.uitm.edu.my/id/eprint/105244/1/105244.PDF text en public degree Universiti Teknologi MARA (Kampus Puncak Alam) Faculty of Pharmacy Mohd Shah, Ismail
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
advisor	Mohd Shah, Ismail
topic	Pharmaceutical industry Pharmaceutical dosage forms Pharmaceutical chemistry
spellingShingle	Pharmaceutical industry Pharmaceutical dosage forms Pharmaceutical chemistry Laharadi @ Lahuri, Maryam Jamilah Structure-based drug modeling of curcuma longa as alternative drug for breast cancer / Maryam Jamilah Laharadi @ Lahuri
description	Overexpression of epidermal growth factor (EGFR) tyrosine kinase was related to occurance, lymph metastasis and pathologic types of breast cancer. lnhibition of the EGFR tyrosine kinase activity by small molecules has proved effective for the treatment of breast cancer. Study has been done before where the crystal structure of EGFR has been used to identify inhibitor chemotypes by docking-based in silico screening of a large virtual chemical library followed up by experimental validation. Several compounds have been identified since then and one of them is Lapatinib which interact with EGFR coded in Protein Data Bank (PDB) as 1 xkk receptor. We analyzed the compound presence in Curcuma longa and identify the one that can give more or less similar effects such as Lapatinib through in silico models.
format	Thesis
qualification_level	Bachelor degree
author	Laharadi @ Lahuri, Maryam Jamilah
author_facet	Laharadi @ Lahuri, Maryam Jamilah
author_sort	Laharadi @ Lahuri, Maryam Jamilah
title	Structure-based drug modeling of curcuma longa as alternative drug for breast cancer / Maryam Jamilah Laharadi @ Lahuri
title_short	Structure-based drug modeling of curcuma longa as alternative drug for breast cancer / Maryam Jamilah Laharadi @ Lahuri
title_full	Structure-based drug modeling of curcuma longa as alternative drug for breast cancer / Maryam Jamilah Laharadi @ Lahuri
title_fullStr	Structure-based drug modeling of curcuma longa as alternative drug for breast cancer / Maryam Jamilah Laharadi @ Lahuri
title_full_unstemmed	Structure-based drug modeling of curcuma longa as alternative drug for breast cancer / Maryam Jamilah Laharadi @ Lahuri
title_sort	structure-based drug modeling of curcuma longa as alternative drug for breast cancer / maryam jamilah laharadi @ lahuri
granting_institution	Universiti Teknologi MARA (Kampus Puncak Alam)
granting_department	Faculty of Pharmacy
publishDate	2009
url	https://ir.uitm.edu.my/id/eprint/105244/1/105244.PDF
_version_	1818588143010447360

Structure-based drug modeling of curcuma longa as alternative drug for breast cancer / Maryam Jamilah Laharadi @ Lahuri

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