In vitro study of astaxanthin release from self nanoemulsifying drug delivery system (SNEDDS) / Mohd Rizal Salleh

The aim of the current study was to compare the release of a poorly soluble model drug compound, astaxanthin, from three lipid-based formulations and one formulation of astaxanthin extracted product in vitro. Drug release of astaxanthin was evaluated in vitro in four dissolution mediums: simulated g...

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Main Author:	Salleh, Mohd Rizal
Format:	Thesis
Language:	English
Published:	2009
Subjects:	Pharmaceutical industry Pharmaceutical dosage forms
Online Access:	https://ir.uitm.edu.my/id/eprint/105403/1/105403.PDF
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id	my-uitm-ir.105403
record_format	uketd_dc
spelling	my-uitm-ir.1054032024-12-04T16:00:39Z In vitro study of astaxanthin release from self nanoemulsifying drug delivery system (SNEDDS) / Mohd Rizal Salleh 2009 Salleh, Mohd Rizal Pharmaceutical industry Pharmaceutical dosage forms The aim of the current study was to compare the release of a poorly soluble model drug compound, astaxanthin, from three lipid-based formulations and one formulation of astaxanthin extracted product in vitro. Drug release of astaxanthin was evaluated in vitro in four dissolution mediums: simulated gastric fluid (SGF), simulated intestinal fluid (SIF), 0.5% Tween 80 and distilled water. An oil solution, two self-micro and nano emulsifying drug delivery systems and one astaxanthin extracted product were tested in the dissolution medium models. The release of astaxanthin to the aqueous phase (dissolution medium) was evaluated by removing 2ml sample at 0 hour and post 15 minutes, 30 minutes, 1 hour (h), 2 h, 3 h, 4 h, 5 h, 6 h, 8 h, 10 h, 12 h and 24 h. The best formulation among the four was found to be SNEDDS which had improved aqueous drug released in all the dissolution media. It is suggested that SNEDDS are physically stable formulations and may offer an improvement in dissolution rates and extents of absorption due to the nanometer sized droplets present. In conclusion, the release profiles in ranking the formulations results in the following order: SNEDDS > SMEDDS - oil solution > distilled water in vitro. On the other hand, distilled water was found as the best medium for enhanced astaxanthin dissolution where drug released was the highest. 2009 Thesis https://ir.uitm.edu.my/id/eprint/105403/ https://ir.uitm.edu.my/id/eprint/105403/1/105403.PDF text en public degree Universiti Teknologi MARA (Kampus Puncak Alam) Faculty of Pharmacy Julianto, Tommy
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
advisor	Julianto, Tommy
topic	Pharmaceutical industry Pharmaceutical dosage forms
spellingShingle	Pharmaceutical industry Pharmaceutical dosage forms Salleh, Mohd Rizal In vitro study of astaxanthin release from self nanoemulsifying drug delivery system (SNEDDS) / Mohd Rizal Salleh
description	The aim of the current study was to compare the release of a poorly soluble model drug compound, astaxanthin, from three lipid-based formulations and one formulation of astaxanthin extracted product in vitro. Drug release of astaxanthin was evaluated in vitro in four dissolution mediums: simulated gastric fluid (SGF), simulated intestinal fluid (SIF), 0.5% Tween 80 and distilled water. An oil solution, two self-micro and nano emulsifying drug delivery systems and one astaxanthin extracted product were tested in the dissolution medium models. The release of astaxanthin to the aqueous phase (dissolution medium) was evaluated by removing 2ml sample at 0 hour and post 15 minutes, 30 minutes, 1 hour (h), 2 h, 3 h, 4 h, 5 h, 6 h, 8 h, 10 h, 12 h and 24 h. The best formulation among the four was found to be SNEDDS which had improved aqueous drug released in all the dissolution media. It is suggested that SNEDDS are physically stable formulations and may offer an improvement in dissolution rates and extents of absorption due to the nanometer sized droplets present. In conclusion, the release profiles in ranking the formulations results in the following order: SNEDDS > SMEDDS - oil solution > distilled water in vitro. On the other hand, distilled water was found as the best medium for enhanced astaxanthin dissolution where drug released was the highest.
format	Thesis
qualification_level	Bachelor degree
author	Salleh, Mohd Rizal
author_facet	Salleh, Mohd Rizal
author_sort	Salleh, Mohd Rizal
title	In vitro study of astaxanthin release from self nanoemulsifying drug delivery system (SNEDDS) / Mohd Rizal Salleh
title_short	In vitro study of astaxanthin release from self nanoemulsifying drug delivery system (SNEDDS) / Mohd Rizal Salleh
title_full	In vitro study of astaxanthin release from self nanoemulsifying drug delivery system (SNEDDS) / Mohd Rizal Salleh
title_fullStr	In vitro study of astaxanthin release from self nanoemulsifying drug delivery system (SNEDDS) / Mohd Rizal Salleh
title_full_unstemmed	In vitro study of astaxanthin release from self nanoemulsifying drug delivery system (SNEDDS) / Mohd Rizal Salleh
title_sort	in vitro study of astaxanthin release from self nanoemulsifying drug delivery system (snedds) / mohd rizal salleh
granting_institution	Universiti Teknologi MARA (Kampus Puncak Alam)
granting_department	Faculty of Pharmacy
publishDate	2009
url	https://ir.uitm.edu.my/id/eprint/105403/1/105403.PDF
_version_	1818588147566510080

In vitro study of astaxanthin release from self nanoemulsifying drug delivery system (SNEDDS) / Mohd Rizal Salleh

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