Histological changes in male reproductive system of dose response bisphenol A (BPA) treated sprague-dawley (SD) rats / Muhammad Faiz Abdul Hadi

Bisphenol A (BPA) is a chemical produced in large quantities for use primarily in the production of polycarbonate plastics and epoxy resins. BPA is also act as potential endocrine disruptor which it mimics the action of estrogen and lead to disorder of reproductive system. In this study, four groups...

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Main Author:	Abdul Hadi, Muhammad Faiz
Format:	Thesis
Language:	English
Published:	2009
Subjects:	Pharmaceutical chemistry
Online Access:	https://ir.uitm.edu.my/id/eprint/105432/1/105432.PDF
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id	my-uitm-ir.105432
record_format	uketd_dc
spelling	my-uitm-ir.1054322024-12-04T14:27:32Z Histological changes in male reproductive system of dose response bisphenol A (BPA) treated sprague-dawley (SD) rats / Muhammad Faiz Abdul Hadi 2009 Abdul Hadi, Muhammad Faiz Pharmaceutical chemistry Bisphenol A (BPA) is a chemical produced in large quantities for use primarily in the production of polycarbonate plastics and epoxy resins. BPA is also act as potential endocrine disruptor which it mimics the action of estrogen and lead to disorder of reproductive system. In this study, four groups of SD rats were administered orally at different dose (50µg/kg/day, 500µg/kg/day, 1000µg/kg/day and 5000µg/kg/day) treatments for 2 weeks. Others groups of SD rats were administered orally with lOµg/kg/day of ethinylestradiol (EE) for 2 weeks. The observations and analysis made in this study was the determination of histological changes in the testis of SD rats when exposed to different doses. Testes were histologically examined by light microscopy at 8 weeks of age. Result indicates that at 50µg/kg/day, there were any no abnormalities found but at 500µg/kg/day, result indicates seminiferous tubule (ST) showing histological abnormality including some changes such as shape of ST was affected, wider interstitial space area was observed and also viewing loss of luminal space. At higher doses of 1000µg/kg/day and 5000µg/kg/day, the abnormality of ST is still observed. The results of the present study show that higher dose of BPA may cause more harmful effects to the SD rat male reproductive system. 2009 Thesis https://ir.uitm.edu.my/id/eprint/105432/ https://ir.uitm.edu.my/id/eprint/105432/1/105432.PDF text en public degree Universiti Teknologi MARA (Kampus Puncak Alam) Faculty of Pharmacy Mohamed, Ruzianisra
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
advisor	Mohamed, Ruzianisra
topic	Pharmaceutical chemistry
spellingShingle	Pharmaceutical chemistry Abdul Hadi, Muhammad Faiz Histological changes in male reproductive system of dose response bisphenol A (BPA) treated sprague-dawley (SD) rats / Muhammad Faiz Abdul Hadi
description	Bisphenol A (BPA) is a chemical produced in large quantities for use primarily in the production of polycarbonate plastics and epoxy resins. BPA is also act as potential endocrine disruptor which it mimics the action of estrogen and lead to disorder of reproductive system. In this study, four groups of SD rats were administered orally at different dose (50µg/kg/day, 500µg/kg/day, 1000µg/kg/day and 5000µg/kg/day) treatments for 2 weeks. Others groups of SD rats were administered orally with lOµg/kg/day of ethinylestradiol (EE) for 2 weeks. The observations and analysis made in this study was the determination of histological changes in the testis of SD rats when exposed to different doses. Testes were histologically examined by light microscopy at 8 weeks of age. Result indicates that at 50µg/kg/day, there were any no abnormalities found but at 500µg/kg/day, result indicates seminiferous tubule (ST) showing histological abnormality including some changes such as shape of ST was affected, wider interstitial space area was observed and also viewing loss of luminal space. At higher doses of 1000µg/kg/day and 5000µg/kg/day, the abnormality of ST is still observed. The results of the present study show that higher dose of BPA may cause more harmful effects to the SD rat male reproductive system.
format	Thesis
qualification_level	Bachelor degree
author	Abdul Hadi, Muhammad Faiz
author_facet	Abdul Hadi, Muhammad Faiz
author_sort	Abdul Hadi, Muhammad Faiz
title	Histological changes in male reproductive system of dose response bisphenol A (BPA) treated sprague-dawley (SD) rats / Muhammad Faiz Abdul Hadi
title_short	Histological changes in male reproductive system of dose response bisphenol A (BPA) treated sprague-dawley (SD) rats / Muhammad Faiz Abdul Hadi
title_full	Histological changes in male reproductive system of dose response bisphenol A (BPA) treated sprague-dawley (SD) rats / Muhammad Faiz Abdul Hadi
title_fullStr	Histological changes in male reproductive system of dose response bisphenol A (BPA) treated sprague-dawley (SD) rats / Muhammad Faiz Abdul Hadi
title_full_unstemmed	Histological changes in male reproductive system of dose response bisphenol A (BPA) treated sprague-dawley (SD) rats / Muhammad Faiz Abdul Hadi
title_sort	histological changes in male reproductive system of dose response bisphenol a (bpa) treated sprague-dawley (sd) rats / muhammad faiz abdul hadi
granting_institution	Universiti Teknologi MARA (Kampus Puncak Alam)
granting_department	Faculty of Pharmacy
publishDate	2009
url	https://ir.uitm.edu.my/id/eprint/105432/1/105432.PDF
_version_	1818588149591310336

Histological changes in male reproductive system of dose response bisphenol A (BPA) treated sprague-dawley (SD) rats / Muhammad Faiz Abdul Hadi

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