Malaysian traditional herbs: CYP-herb interaction from the perspective of CYP3A4 inhibition / Syaza Zuhairah Suhaimi

The use of vitamins and herbal supplements has spread over the nation vastly among the population, with the primary factor being to manage the side effects of drugs or to improve overall physical and mental health. The active ingredients of a single herb may exhibit some degree of pharmacological ef...

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Main Author:	Suhaimi, Syaza Zuhairah
Format:	Thesis
Language:	English
Published:	2009
Subjects:	Pharmaceutical industry Pharmaceutical chemistry
Online Access:	https://ir.uitm.edu.my/id/eprint/105526/1/105526.PDF
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id	my-uitm-ir.105526
record_format	uketd_dc
spelling	my-uitm-ir.1055262024-12-05T08:48:48Z Malaysian traditional herbs: CYP-herb interaction from the perspective of CYP3A4 inhibition / Syaza Zuhairah Suhaimi 2009 Suhaimi, Syaza Zuhairah Pharmaceutical industry Pharmacognosy. Pharmaceutical substances (Plant, animal, and inorganic) Pharmaceutical chemistry The use of vitamins and herbal supplements has spread over the nation vastly among the population, with the primary factor being to manage the side effects of drugs or to improve overall physical and mental health. The active ingredients of a single herb may exhibit some degree of pharmacological effects, which may be the inhibitory or inducing to the chemical components of an allopathic medicine (Miller, 1998). The purpose of the study is to identify potential herb-drug interactions between 56 local herbs and allopathic medicines by looking at the activity of cytochrome P450 3A4 (CYP3A4). This study was conducted on 56 Malaysian traditional herbs using Invitrogen CYP3A4 Screening Kit (lnvitrogen Corp., USA). Data were gathered and analysed, from the results obtained, it was found that 17 herbs showed positive inhibition on CYP3A4 activity, while 49 herbs showed no inhibition towards the activity of CYP3A4. The study also revealed that positive inhibition of CYP3A4 activity may consequently affect the metabolism of concomitant drug intake which are the substrates of CYP3A4 and may cause prolonged effect of drug and also drug-induced toxicity. Based on the study some recommendations on further assessment of the herbs are put forward in the final section of this paper. 2009 Thesis https://ir.uitm.edu.my/id/eprint/105526/ https://ir.uitm.edu.my/id/eprint/105526/1/105526.PDF text en public degree Universiti Teknologi MARA (Kampus Puncak Alam) Faculty of Pharmacy Choo, Chee Yan
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
advisor	Choo, Chee Yan
topic	Pharmaceutical industry Pharmaceutical industry Pharmaceutical chemistry
spellingShingle	Pharmaceutical industry Pharmaceutical industry Pharmaceutical chemistry Suhaimi, Syaza Zuhairah Malaysian traditional herbs: CYP-herb interaction from the perspective of CYP3A4 inhibition / Syaza Zuhairah Suhaimi
description	The use of vitamins and herbal supplements has spread over the nation vastly among the population, with the primary factor being to manage the side effects of drugs or to improve overall physical and mental health. The active ingredients of a single herb may exhibit some degree of pharmacological effects, which may be the inhibitory or inducing to the chemical components of an allopathic medicine (Miller, 1998). The purpose of the study is to identify potential herb-drug interactions between 56 local herbs and allopathic medicines by looking at the activity of cytochrome P450 3A4 (CYP3A4). This study was conducted on 56 Malaysian traditional herbs using Invitrogen CYP3A4 Screening Kit (lnvitrogen Corp., USA). Data were gathered and analysed, from the results obtained, it was found that 17 herbs showed positive inhibition on CYP3A4 activity, while 49 herbs showed no inhibition towards the activity of CYP3A4. The study also revealed that positive inhibition of CYP3A4 activity may consequently affect the metabolism of concomitant drug intake which are the substrates of CYP3A4 and may cause prolonged effect of drug and also drug-induced toxicity. Based on the study some recommendations on further assessment of the herbs are put forward in the final section of this paper.
format	Thesis
qualification_level	Bachelor degree
author	Suhaimi, Syaza Zuhairah
author_facet	Suhaimi, Syaza Zuhairah
author_sort	Suhaimi, Syaza Zuhairah
title	Malaysian traditional herbs: CYP-herb interaction from the perspective of CYP3A4 inhibition / Syaza Zuhairah Suhaimi
title_short	Malaysian traditional herbs: CYP-herb interaction from the perspective of CYP3A4 inhibition / Syaza Zuhairah Suhaimi
title_full	Malaysian traditional herbs: CYP-herb interaction from the perspective of CYP3A4 inhibition / Syaza Zuhairah Suhaimi
title_fullStr	Malaysian traditional herbs: CYP-herb interaction from the perspective of CYP3A4 inhibition / Syaza Zuhairah Suhaimi
title_full_unstemmed	Malaysian traditional herbs: CYP-herb interaction from the perspective of CYP3A4 inhibition / Syaza Zuhairah Suhaimi
title_sort	malaysian traditional herbs: cyp-herb interaction from the perspective of cyp3a4 inhibition / syaza zuhairah suhaimi
granting_institution	Universiti Teknologi MARA (Kampus Puncak Alam)
granting_department	Faculty of Pharmacy
publishDate	2009
url	https://ir.uitm.edu.my/id/eprint/105526/1/105526.PDF
_version_	1818588151357112320

Malaysian traditional herbs: CYP-herb interaction from the perspective of CYP3A4 inhibition / Syaza Zuhairah Suhaimi

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