Preparation and evaluation of the surface properties of griseofulvin solid dispersions with three different saccharides / Kamal Rasyid Samsudin

The present study proposed griseofulvin as drug candidate because of its aqueous in solubility, where it foresees to study contact angle extensively as a parameter and to establish how different saccharides such as lactose, com starch and potato starch incorporate hydrophilicity to a hydrophobic dru...

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Main Author:	Samsudin, Kamal Rasyid
Format:	Thesis
Language:	English
Published:	2009
Subjects:	Pharmaceutical industry Pharmaceutical chemistry
Online Access:	https://ir.uitm.edu.my/id/eprint/105529/1/105529.PDF
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id	my-uitm-ir.105529
record_format	uketd_dc
spelling	my-uitm-ir.1055292024-12-05T08:48:45Z Preparation and evaluation of the surface properties of griseofulvin solid dispersions with three different saccharides / Kamal Rasyid Samsudin 2009 Samsudin, Kamal Rasyid Pharmaceutical industry Pharmaceutical chemistry The present study proposed griseofulvin as drug candidate because of its aqueous in solubility, where it foresees to study contact angle extensively as a parameter and to establish how different saccharides such as lactose, com starch and potato starch incorporate hydrophilicity to a hydrophobic drug so to enhance its solubility. The effects of contact angle on the mixture of griseofulvin with saccharides were investigated by using sessile drop method. The pellets containing the mixture of griseofulvin and saccharides were measured at ratio (1:1, 1:2, 1:3, 1:4, 1:5, 1:6, 1:7, 1:8) by weight. For griseofulvin alone, the contact angle was observed to be very high, 65.58°, supporting the fact that the drug is very hydrophobic. Upon incorporation of lactose, com starch and potato starch, the contact angle was decreased with different extent of intensity corresponding to the different saccharides respectively. Upon comparison, presence of com starch significantly improved the wettability of griseofulvin as it reduces the contact angle to the highest extent among the three, suggesting it can better incorporate hydrophilic property than that of the other two saccharides. On the basis of this study, an extensive data on contact angle have been gathered, however, these findings have to be further validated with other related experimental findings. 2009 Thesis https://ir.uitm.edu.my/id/eprint/105529/ https://ir.uitm.edu.my/id/eprint/105529/1/105529.PDF text en public degree Universiti Teknologi MARA (Kampus Puncak Alam) Faculty of Pharmacy Tripathy, Minaketan
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
advisor	Tripathy, Minaketan
topic	Pharmaceutical industry Pharmaceutical chemistry
spellingShingle	Pharmaceutical industry Pharmaceutical chemistry Samsudin, Kamal Rasyid Preparation and evaluation of the surface properties of griseofulvin solid dispersions with three different saccharides / Kamal Rasyid Samsudin
description	The present study proposed griseofulvin as drug candidate because of its aqueous in solubility, where it foresees to study contact angle extensively as a parameter and to establish how different saccharides such as lactose, com starch and potato starch incorporate hydrophilicity to a hydrophobic drug so to enhance its solubility. The effects of contact angle on the mixture of griseofulvin with saccharides were investigated by using sessile drop method. The pellets containing the mixture of griseofulvin and saccharides were measured at ratio (1:1, 1:2, 1:3, 1:4, 1:5, 1:6, 1:7, 1:8) by weight. For griseofulvin alone, the contact angle was observed to be very high, 65.58°, supporting the fact that the drug is very hydrophobic. Upon incorporation of lactose, com starch and potato starch, the contact angle was decreased with different extent of intensity corresponding to the different saccharides respectively. Upon comparison, presence of com starch significantly improved the wettability of griseofulvin as it reduces the contact angle to the highest extent among the three, suggesting it can better incorporate hydrophilic property than that of the other two saccharides. On the basis of this study, an extensive data on contact angle have been gathered, however, these findings have to be further validated with other related experimental findings.
format	Thesis
qualification_level	Bachelor degree
author	Samsudin, Kamal Rasyid
author_facet	Samsudin, Kamal Rasyid
author_sort	Samsudin, Kamal Rasyid
title	Preparation and evaluation of the surface properties of griseofulvin solid dispersions with three different saccharides / Kamal Rasyid Samsudin
title_short	Preparation and evaluation of the surface properties of griseofulvin solid dispersions with three different saccharides / Kamal Rasyid Samsudin
title_full	Preparation and evaluation of the surface properties of griseofulvin solid dispersions with three different saccharides / Kamal Rasyid Samsudin
title_fullStr	Preparation and evaluation of the surface properties of griseofulvin solid dispersions with three different saccharides / Kamal Rasyid Samsudin
title_full_unstemmed	Preparation and evaluation of the surface properties of griseofulvin solid dispersions with three different saccharides / Kamal Rasyid Samsudin
title_sort	preparation and evaluation of the surface properties of griseofulvin solid dispersions with three different saccharides / kamal rasyid samsudin
granting_institution	Universiti Teknologi MARA (Kampus Puncak Alam)
granting_department	Faculty of Pharmacy
publishDate	2009
url	https://ir.uitm.edu.my/id/eprint/105529/1/105529.PDF
_version_	1818588151609819136

Preparation and evaluation of the surface properties of griseofulvin solid dispersions with three different saccharides / Kamal Rasyid Samsudin

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