PLGA nanoparticles for sustained release using sucrose ester as an alternative surfactant / Wan Nurul Huda W. Hasan

Sucrose esters (SE) are surfactants with potential pharmaceutical application as it has low toxicity, excellent biocompatibility and biodegradibilty. The objective of the study is to investigate SE as alternative surfactants in stabilizing emulsions for the preparation of drug-loaded nanoparticles....

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Main Author:	W. Hasan, Wan Nurul Huda
Format:	Thesis
Language:	English
Published:	2009
Subjects:	Pharmaceutical industry Pharmaceutical chemistry
Online Access:	https://ir.uitm.edu.my/id/eprint/107029/1/107029.PDF
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id	my-uitm-ir.107029
record_format	uketd_dc
spelling	my-uitm-ir.1070292024-12-10T23:13:12Z PLGA nanoparticles for sustained release using sucrose ester as an alternative surfactant / Wan Nurul Huda W. Hasan 2009 W. Hasan, Wan Nurul Huda Pharmaceutical industry Pharmaceutical chemistry Sucrose esters (SE) are surfactants with potential pharmaceutical application as it has low toxicity, excellent biocompatibility and biodegradibilty. The objective of the study is to investigate SE as alternative surfactants in stabilizing emulsions for the preparation of drug-loaded nanoparticles. To achieve this goal, using ibuprofen as drug carrier and 50:50 poly(d,lactide-co-glycolide) as polymer carrier, the study investigated first the influence of the following variables on blank nanoparticle characteristics: (I) hydrophile lipophile balance (HLB) of SE palmitate, (2) homogenizing speed and (3) homogenizing time. Results showed that particles characteristic were at best when using HLB 15 of SE at homogenizing speed and time (#I, 60 seconds). The later ibuprofen-loaded nanoparticles made using this optimal parameters revealed a relatively acceptable encapsulation efficiency more than 50%. In term of dug release, there was high initial burst release followed by the more constant release thereafter. This study may suggest that many options can be done in order to optimize the stability, particles characteristics of the nanoparticles as well as drug content and encapsulation efficiency which may be helpful in the development of nanoparticle system for parenteral delivery of drug, protein and gene medicine, by using SE as an alternative surfactant. 2009 Thesis https://ir.uitm.edu.my/id/eprint/107029/ https://ir.uitm.edu.my/id/eprint/107029/1/107029.PDF text en public degree Universiti Teknologi MARA (Kampus Puncak Alam) Faculty of Pharmacy Sameni, Javad Khadem
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
advisor	Sameni, Javad Khadem
topic	Pharmaceutical industry Pharmaceutical chemistry
spellingShingle	Pharmaceutical industry Pharmaceutical chemistry W. Hasan, Wan Nurul Huda PLGA nanoparticles for sustained release using sucrose ester as an alternative surfactant / Wan Nurul Huda W. Hasan
description	Sucrose esters (SE) are surfactants with potential pharmaceutical application as it has low toxicity, excellent biocompatibility and biodegradibilty. The objective of the study is to investigate SE as alternative surfactants in stabilizing emulsions for the preparation of drug-loaded nanoparticles. To achieve this goal, using ibuprofen as drug carrier and 50:50 poly(d,lactide-co-glycolide) as polymer carrier, the study investigated first the influence of the following variables on blank nanoparticle characteristics: (I) hydrophile lipophile balance (HLB) of SE palmitate, (2) homogenizing speed and (3) homogenizing time. Results showed that particles characteristic were at best when using HLB 15 of SE at homogenizing speed and time (#I, 60 seconds). The later ibuprofen-loaded nanoparticles made using this optimal parameters revealed a relatively acceptable encapsulation efficiency more than 50%. In term of dug release, there was high initial burst release followed by the more constant release thereafter. This study may suggest that many options can be done in order to optimize the stability, particles characteristics of the nanoparticles as well as drug content and encapsulation efficiency which may be helpful in the development of nanoparticle system for parenteral delivery of drug, protein and gene medicine, by using SE as an alternative surfactant.
format	Thesis
qualification_level	Bachelor degree
author	W. Hasan, Wan Nurul Huda
author_facet	W. Hasan, Wan Nurul Huda
author_sort	W. Hasan, Wan Nurul Huda
title	PLGA nanoparticles for sustained release using sucrose ester as an alternative surfactant / Wan Nurul Huda W. Hasan
title_short	PLGA nanoparticles for sustained release using sucrose ester as an alternative surfactant / Wan Nurul Huda W. Hasan
title_full	PLGA nanoparticles for sustained release using sucrose ester as an alternative surfactant / Wan Nurul Huda W. Hasan
title_fullStr	PLGA nanoparticles for sustained release using sucrose ester as an alternative surfactant / Wan Nurul Huda W. Hasan
title_full_unstemmed	PLGA nanoparticles for sustained release using sucrose ester as an alternative surfactant / Wan Nurul Huda W. Hasan
title_sort	plga nanoparticles for sustained release using sucrose ester as an alternative surfactant / wan nurul huda w. hasan
granting_institution	Universiti Teknologi MARA (Kampus Puncak Alam)
granting_department	Faculty of Pharmacy
publishDate	2009
url	https://ir.uitm.edu.my/id/eprint/107029/1/107029.PDF
_version_	1818588201341681664

PLGA nanoparticles for sustained release using sucrose ester as an alternative surfactant / Wan Nurul Huda W. Hasan

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