Microbial transformation of glycyrrhizic acid and identification of their secondary metabolites through LCMS and NMR / Fatin Farhanah Jamil

The mam objective of our study is to be able to observe the process of microbial transformation on biologically active compound, glycyrrhizic acid, and to identify the secondary metabolites generated when glycyrrhizic acid is subjected to microbial transformation by using HPLC and NMR. In achieving...

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Main Author:	Jamil, Fatin Farhanah
Format:	Thesis
Language:	English
Published:	2009
Subjects:	Pharmaceutical industry
Online Access:	https://ir.uitm.edu.my/id/eprint/107166/1/107166.PDF
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id	my-uitm-ir.107166
record_format	uketd_dc
spelling	my-uitm-ir.1071662024-12-10T23:08:03Z Microbial transformation of glycyrrhizic acid and identification of their secondary metabolites through LCMS and NMR / Fatin Farhanah Jamil 2009 Jamil, Fatin Farhanah Pharmaceutical industry The mam objective of our study is to be able to observe the process of microbial transformation on biologically active compound, glycyrrhizic acid, and to identify the secondary metabolites generated when glycyrrhizic acid is subjected to microbial transformation by using HPLC and NMR. In achieving the objectives of our study, there are two particular steps involve which were primary screening of secondary metabolites and large scale production of secondary metabolites. Primary screening was done in order to check which fungi transform the most potential and abundant secondary metabolites from glycyrrhizic acid. After the first step was performed, Trichothecium roseum was chosen as the fungi of interest for the large scale production and we was able to identify few secondary metabolites generated from Trichothecium roseum from HPLC chromatogram observed. Our research however was limited to HPLC identification. Structural elucidation by NMR cannot be done because of time limitation. 2009 Thesis https://ir.uitm.edu.my/id/eprint/107166/ https://ir.uitm.edu.my/id/eprint/107166/1/107166.PDF text en public degree Universiti Teknologi MARA (Kampus Puncak Alam) Faculty of Pharmacy Ali Shah, Syed Adnan
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
advisor	Ali Shah, Syed Adnan
topic	Pharmaceutical industry
spellingShingle	Pharmaceutical industry Jamil, Fatin Farhanah Microbial transformation of glycyrrhizic acid and identification of their secondary metabolites through LCMS and NMR / Fatin Farhanah Jamil
description	The mam objective of our study is to be able to observe the process of microbial transformation on biologically active compound, glycyrrhizic acid, and to identify the secondary metabolites generated when glycyrrhizic acid is subjected to microbial transformation by using HPLC and NMR. In achieving the objectives of our study, there are two particular steps involve which were primary screening of secondary metabolites and large scale production of secondary metabolites. Primary screening was done in order to check which fungi transform the most potential and abundant secondary metabolites from glycyrrhizic acid. After the first step was performed, Trichothecium roseum was chosen as the fungi of interest for the large scale production and we was able to identify few secondary metabolites generated from Trichothecium roseum from HPLC chromatogram observed. Our research however was limited to HPLC identification. Structural elucidation by NMR cannot be done because of time limitation.
format	Thesis
qualification_level	Bachelor degree
author	Jamil, Fatin Farhanah
author_facet	Jamil, Fatin Farhanah
author_sort	Jamil, Fatin Farhanah
title	Microbial transformation of glycyrrhizic acid and identification of their secondary metabolites through LCMS and NMR / Fatin Farhanah Jamil
title_short	Microbial transformation of glycyrrhizic acid and identification of their secondary metabolites through LCMS and NMR / Fatin Farhanah Jamil
title_full	Microbial transformation of glycyrrhizic acid and identification of their secondary metabolites through LCMS and NMR / Fatin Farhanah Jamil
title_fullStr	Microbial transformation of glycyrrhizic acid and identification of their secondary metabolites through LCMS and NMR / Fatin Farhanah Jamil
title_full_unstemmed	Microbial transformation of glycyrrhizic acid and identification of their secondary metabolites through LCMS and NMR / Fatin Farhanah Jamil
title_sort	microbial transformation of glycyrrhizic acid and identification of their secondary metabolites through lcms and nmr / fatin farhanah jamil
granting_institution	Universiti Teknologi MARA (Kampus Puncak Alam)
granting_department	Faculty of Pharmacy
publishDate	2009
url	https://ir.uitm.edu.my/id/eprint/107166/1/107166.PDF
_version_	1818588210912034816

Microbial transformation of glycyrrhizic acid and identification of their secondary metabolites through LCMS and NMR / Fatin Farhanah Jamil

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