Pharmaceutical properties and in vitro evaluation of ibuprofen-loaded PLGA nanoparticles by nanoprecipitation / Fatimah Tul Zahraa' Mahmud Pathi
The main objective of this study was to develop a polymeric drug delivery system for ibuprofen with final goal of improving the delivery of poor water soluble drugs. In order to achieve this goal, ibuprofen-loaded PLGA nanoparticles were prepared by the nanoprecipitation method. The following charac...
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2009
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my-uitm-ir.1071712024-12-10T23:08:11Z Pharmaceutical properties and in vitro evaluation of ibuprofen-loaded PLGA nanoparticles by nanoprecipitation / Fatimah Tul Zahraa' Mahmud Pathi 2009 Mahmud Pathi, Fatimah Tul Zahraa' Pharmaceutical industry Pharmaceutical chemistry The main objective of this study was to develop a polymeric drug delivery system for ibuprofen with final goal of improving the delivery of poor water soluble drugs. In order to achieve this goal, ibuprofen-loaded PLGA nanoparticles were prepared by the nanoprecipitation method. The following characteristics of nanoparticles formulate were determined; particle sizes, zeta potential, drug content, drug entrapment and drug release profile. Our result demonstrate that the methodology of preparation allowed the formation of nanometric ( <200 nm), a narrow size distribution ( polydispersity index< 0.2) and a negative surface charge (zeta potential values ranging from -27.4 to -31.3 m V). The release behaviour of ibuprofen from the developed nanoparticles exhibited a biphasic pattern characteristic by an initial fast release during the first 7 hours, followed by a slower and continues release. The formulation was optimised by 30% of theoretical drug loading with highest percentage of drug entrapment of 74.63% and drug content of 58.09%. The study has demonstrated that incorporation of ibuprofen in PLGA can improve drug release profile. 2009 Thesis https://ir.uitm.edu.my/id/eprint/107171/ https://ir.uitm.edu.my/id/eprint/107171/1/107171.PDF text en public degree Universiti Teknologi MARA (Kampus Puncak Alam) Faculty of Pharmacy Sameni, Javad |
| institution |
Universiti Teknologi MARA |
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UiTM Institutional Repository |
| language |
English |
| advisor |
Sameni, Javad |
| topic |
Pharmaceutical industry Pharmaceutical chemistry |
| spellingShingle |
Pharmaceutical industry Pharmaceutical chemistry Mahmud Pathi, Fatimah Tul Zahraa' Pharmaceutical properties and in vitro evaluation of ibuprofen-loaded PLGA nanoparticles by nanoprecipitation / Fatimah Tul Zahraa' Mahmud Pathi |
| description |
The main objective of this study was to develop a polymeric drug delivery system for ibuprofen with final goal of improving the delivery of poor water soluble drugs. In order to achieve this goal, ibuprofen-loaded PLGA nanoparticles were prepared by the nanoprecipitation method. The following characteristics of nanoparticles formulate were determined; particle sizes, zeta potential, drug content, drug entrapment and drug release profile. Our result demonstrate that the methodology of preparation allowed the formation of nanometric ( <200 nm), a narrow size distribution ( polydispersity index< 0.2) and a negative surface charge (zeta potential values ranging from -27.4 to -31.3 m V). The release behaviour of ibuprofen from the developed nanoparticles exhibited a biphasic pattern characteristic by an initial fast release during the first 7 hours, followed by a slower and continues release. The formulation was optimised by 30% of theoretical drug loading with highest percentage of drug entrapment of 74.63% and drug content of 58.09%. The study has demonstrated that incorporation of ibuprofen in PLGA can improve drug release profile. |
| format |
Thesis |
| qualification_level |
Bachelor degree |
| author |
Mahmud Pathi, Fatimah Tul Zahraa' |
| author_facet |
Mahmud Pathi, Fatimah Tul Zahraa' |
| author_sort |
Mahmud Pathi, Fatimah Tul Zahraa' |
| title |
Pharmaceutical properties and in vitro evaluation of ibuprofen-loaded PLGA nanoparticles by nanoprecipitation / Fatimah Tul Zahraa' Mahmud Pathi |
| title_short |
Pharmaceutical properties and in vitro evaluation of ibuprofen-loaded PLGA nanoparticles by nanoprecipitation / Fatimah Tul Zahraa' Mahmud Pathi |
| title_full |
Pharmaceutical properties and in vitro evaluation of ibuprofen-loaded PLGA nanoparticles by nanoprecipitation / Fatimah Tul Zahraa' Mahmud Pathi |
| title_fullStr |
Pharmaceutical properties and in vitro evaluation of ibuprofen-loaded PLGA nanoparticles by nanoprecipitation / Fatimah Tul Zahraa' Mahmud Pathi |
| title_full_unstemmed |
Pharmaceutical properties and in vitro evaluation of ibuprofen-loaded PLGA nanoparticles by nanoprecipitation / Fatimah Tul Zahraa' Mahmud Pathi |
| title_sort |
pharmaceutical properties and in vitro evaluation of ibuprofen-loaded plga nanoparticles by nanoprecipitation / fatimah tul zahraa' mahmud pathi |
| granting_institution |
Universiti Teknologi MARA (Kampus Puncak Alam) |
| granting_department |
Faculty of Pharmacy |
| publishDate |
2009 |
| url |
https://ir.uitm.edu.my/id/eprint/107171/1/107171.PDF |
| _version_ |
1818588211662815232 |